arXiv subjects

Christos Chrysanthos Nikolaidis

Publications and source records attributed to Christos Chrysanthos Nikolaidis.

3 recordsLinked to original sources

arXiv2026

Robust and Explainable Bicuspid Aortic Valve Diagnosis Using Stacked Ensembles on Echocardiography

Transthoracic echocardiography (TTE) is the first-line imaging modality for diagnosing bicuspid aortic valve (BAV), yet diagnostic performance varies with operator expertise and image quality. We developed an explainable AI model that distinguishes BAV from tricuspid aortic valves (TAV) using routinely acquired parasternal long-axis (PLAX) cine loops. A multi-backbone video ensemble was trained and evaluated using a leakage-aware, stratified outer cross-validation protocol on $N{=}90$ patient studies (48 BAV, 42 TAV). Across fixed outer splits and 10 random seeds, the calibrated stacked ensemble achieved an outer-CV F1-score of $0.907$ and recall of $0.877$. Frame-level Grad-CAM localized salient evidence to the aortic root and leaflet plane, while globally aggregated SHAP values quantified each video backbone's contribution to the stacked prediction, enabling transparent, case-level auditability. These findings indicate that PLAX-based video ensembles can support reliable BAV/TAV classification from routine echocardiographic cine loops and may facilitate earlier detection in non-specialist or resource-limited clinical settings.

cs.LG↗

arXiv2026

Evaluating the Defense Potential of Machine Unlearning against Membership Inference Attacks

Membership Inference Attacks (MIAs) pose a significant privacy risk by enabling adversaries to determine if a specific data point was part of a model's training set. This work empirically investigates whether MU algorithms can function as a targeted, active defense mechanism, in scenarios where a privacy audit identifies specific classes or individuals as highly susceptible to MIAs post-training. By 'dulling' the model's categorical memory of these samples, the process effectively mitigates the membership signal and reduces the MIA success rate for the most vulnerable users. We evaluate the defense potential of three MU algorithms, Negative Gradient (neg grad), SCalable Remembering and Unlearning unBound (SCRUB), and Selective Fine-tuning and Targeted Confusion (SFTC), across four diverse datasets and three complexity-based model groups. Our findings reveal that MU can function as a countermeasure against MIAs, though its success is critically contingent on algorithm choice, model capacity, and a profound sensitivity to learning rates. While Negative Gradient often induces a generalized degradation of membership signals across both forget and retain set, SFTC identifies a critical ``divergence effect'' where targeted forgetting reinforces the membership signal of retained data. Conversely, SCRUB provides a more balanced defense with minimal collateral impact on MIA perspective.

cs.CR↗

arXiv2023

Federated Learning for Early Dropout Prediction on Healthy Ageing Applications

The provision of social care applications is crucial for elderly people to improve their quality of life and enables operators to provide early interventions. Accurate predictions of user dropouts in healthy ageing applications are essential since they are directly related to individual health statuses. Machine Learning (ML) algorithms have enabled highly accurate predictions, outperforming traditional statistical methods that struggle to cope with individual patterns. However, ML requires a substantial amount of data for training, which is challenging due to the presence of personal identifiable information (PII) and the fragmentation posed by regulations. In this paper, we present a federated machine learning (FML) approach that minimizes privacy concerns and enables distributed training, without transferring individual data. We employ collaborative training by considering individuals and organizations under FML, which models both cross-device and cross-silo learning scenarios. Our approach is evaluated on a real-world dataset with non-independent and identically distributed (non-iid) data among clients, class imbalance and label ambiguity. Our results show that data selection and class imbalance handling techniques significantly improve the predictive accuracy of models trained under FML, demonstrating comparable or superior predictive performance than traditional ML models.

cs.LG↗