arXiv subjects

Chuan Hong

Publications and source records attributed to Chuan Hong.

41 records · Page 3Linked to original sources

arXiv2023

FedScore: A privacy-preserving framework for federated scoring system development

We propose FedScore, a privacy-preserving federated learning framework for scoring system generation across multiple sites to facilitate cross-institutional collaborations. The FedScore framework includes five modules: federated variable ranking, federated variable transformation, federated score derivation, federated model selection and federated model evaluation. To illustrate usage and assess FedScore's performance, we built a hypothetical global scoring system for mortality prediction within 30 days after a visit to an emergency department using 10 simulated sites divided from a tertiary hospital in Singapore. We employed a pre-existing score generator to construct 10 local scoring systems independently at each site and we also developed a scoring system using centralized data for comparison. We compared the acquired FedScore model's performance with that of other scoring models using the receiver operating characteristic (ROC) analysis. The FedScore model achieved an average area under the curve (AUC) value of 0.763 across all sites, with a standard deviation (SD) of 0.020. We also calculated the average AUC values and SDs for each local model, and the FedScore model showed promising accuracy and stability with a high average AUC value which was closest to the one of the pooled model and SD which was lower than that of most local models. This study demonstrates that FedScore is a privacy-preserving scoring system generator with potentially good generalizability.

cs.LG↗

arXiv2022

Harnessing electronic health records for real-world evidence

While randomized controlled trials (RCTs) are the gold-standard for establishing the efficacy and safety of a medical treatment, real-world evidence (RWE) generated from real-world data (RWD) has been vital in post-approval monitoring and is being promoted for the regulatory process of experimental therapies. An emerging source of RWD is electronic health records (EHRs), which contain detailed information on patient care in both structured (e. g., diagnosis codes) and unstructured (e. g., clinical notes, images) form. Despite the granularity of the data available in EHRs, critical variables required to reliably assess the relationship between a treatment and clinical outcome can be challenging to extract. We provide an integrated data curation and modeling pipeline leveraging recent advances in natural language processing, computational phenotyping, modeling techniques with noisy data to address this fundamental challenge and accelerate the reliable use of EHRs for RWE, as well as the creation of digital twins. The proposed pipeline is highly automated for the task and includes guidance for deployment. Examples are also drawn from existing literature on EHR emulation of RCT and accompanied by our own studies with Mass General Brigham (MGB) EHR.

stat.AP↗

arXiv2020

High-throughput relation extraction algorithm development associating knowledge articles and electronic health records

Objective: Medical relations are the core components of medical knowledge graphs that are needed for healthcare artificial intelligence. However, the requirement of expert annotation by conventional algorithm development processes creates a major bottleneck for mining new relations. In this paper, we present Hi-RES, a framework for high-throughput relation extraction algorithm development. We also show that combining knowledge articles with electronic health records (EHRs) significantly increases the classification accuracy. Methods: We use relation triplets obtained from structured databases and semistructured webpages to label sentences from target corpora as positive training samples. Two methods are also provided for creating improved negative samples by combining positive samples with naïve negative samples. We propose a common model that summarizes sentence information using large-scale pretrained language models and multi-instance attention, which then joins with the concept embeddings trained from the EHRs for relation prediction. Results: We apply the Hi-RES framework to develop classification algorithms for disorder-disorder relations and disorder-location relations. Millions of sentences are created as training data. Using pretrained language models and EHR-based embeddings individually provides considerable accuracy increases over those of previous models. Joining them together further tremendously increases the accuracy to 0.947 and 0.998 for the two sets of relations, respectively, which are 10-17 percentage points higher than those of previous models. Conclusion: Hi-RES is an efficient framework for achieving high-throughput and accurate relation extraction algorithm development.

cs.LG↗

arXiv2020

A regression-based method for detecting publication bias in multivariate meta-analysis

Publication bias occurs when the publication of research results depends not only on the quality of the research but also on its nature and direction. The consequence is that published studies may not be truly representative of all valid studies undertaken, and this bias may threaten the validity of systematic reviews and meta-analyses - on which evidence-based medicine increasingly relies. Multivariate meta-analysis has recently received increasing attention for its ability reducing potential bias and improving statistical efficiency by borrowing information across outcomes. However, detecting and accounting for publication bias are more challenging in multivariate meta-analysis setting because some studies may be completely unpublished whereas some studies may selectively report part of multiple outcomes. In this paper, we propose a score test for jointly testing publication bias for multiple outcomes, which is novel to the multivariate setting. The proposed test is a natural multivariate extension of the univariate Egger's test, and can handle the above mentioned scenarios simultaneously, It accounts for correlations among multivariate outcomes, while allowing different types of outcomes, and can borrow information across outcomes. The proposed test is shown to be more powerful than the Egger's test, Begg's test and Trim and Fill method through simulation studies. Two data analyses are given to illustrate the performance of the proposed test in practice.

stat.ME↗

arXiv2018

Testing small study effects in multivariate meta-analysis

Small study effects occur when smaller studies show different, often larger, treatment effects than large ones, which may threaten the validity of systematic reviews and meta-analyses. The most well-known reasons for small study effects include publication bias, outcome reporting bias and clinical heterogeneity. Methods to account for small study effects in univariate meta-analysis have been extensively studied. However, detecting small study effects in a multivariate meta-analysis setting remains an untouched research area. One of the complications is that different types of selection processes can be involved in the reporting of multivariate outcomes. For example, some studies may be completely unpublished while others may selectively report multiple outcomes. In this paper, we propose a score test as an overall test of small study effects in multivariate meta-analysis. Two detailed case studies are given to demonstrate the advantage of the proposed test over various naive applications of univariate tests in practice. Through simulation studies, the proposed test is found to retain nominal Type I error with considerable power in moderate sample size settings. Finally, we also evaluate the concordance between the proposed test with the naive application of univariate tests by evaluating 44 systematic reviews with multiple outcomes from the Cochrane Database.

stat.ME↗