arXiv subjects

Chulong Zhang

Publications and source records attributed to Chulong Zhang.

11 recordsLinked to original sources

arXiv2026

Visualizing the Invisible: Enhancing Radiologist Performance in Breast Mammography via Task-Driven Chromatic Encoding

Purpose:Mammography screening is less sensitive in dense breasts, where tissue overlap and subtle findings increase perceptual difficulty. We present MammoColor, an end-to-end framework with a Task-Driven Chromatic Encoding (TDCE) module that converts single-channel mammograms into TDCE-encoded views for visual augmentation. Materials and Methods:MammoColor couples a lightweight TDCE module with a BI-RADS triage classifier and was trained end-to-end on VinDr-Mammo. Performance was evaluated on an internal test set, two public datasets (CBIS-DDSM and INBreast), and three external clinical cohorts. We also conducted a multi-reader, multi-case (MRMC) observer study with a washout period, comparing (1) grayscale-only, (2) TDCE-only, and (3) side-by-side grayscale+TDCE. Results:On VinDr-Mammo, MammoColor improved AUC from 0.7669 to 0.8461 (P=0.004). Gains were larger in dense breasts (AUC 0.749 to 0.835). In the MRMC study, TDCE-encoded images improved specificity (0.90 to 0.96; P=0.052) with comparable sensitivity. Conclusion:TDCE provides a task-optimized chromatic representation that may improve perceptual salience and reduce false-positive recalls in mammography triage.

cs.CV↗

arXiv2026

Data-Efficient Meningioma Segmentation via Implicit Spatiotemporal Mixing and Sim2Real Semantic Injection

The performance of medical image segmentation is increasingly defined by the efficiency of data utilization rather than merely the volume of raw data. Accurate segmentation, particularly for complex pathologies like meningiomas, demands that models fully exploit the latent information within limited high-quality annotations. To maximize the value of existing datasets, we propose a novel dual-augmentation framework that synergistically integrates spatial manifold expansion and semantic object injection. Specifically, we leverage Implicit Neural Representations (INR) to model continuous velocity fields. Unlike previous methods, we perform linear mixing on the integrated deformation fields, enabling the efficient generation of anatomically plausible variations by interpolating within the deformation space. This approach allows for the extensive exploration of structural diversity from a small set of anchors. Furthermore, we introduce a Sim2Real lesion injection module. This module constructs a high-fidelity simulation domain by transplanting lesion textures into healthy anatomical backgrounds, effectively bridging the gap between synthetic augmentation and real-world pathology. Comprehensive experiments on a hybrid dataset demonstrate that our framework significantly enhances the data efficiency and robustness of state-of-the-art models, including nnU-Net and U-Mamba, offering a potent strategy for high-performance medical image analysis with limited annotation budgets.

cs.CV↗

arXiv2025

Mammo-Clustering: Context Clustering based Multi-view Tri Level Information Fusion for Lesion Location and Classification in Mammography

Breast cancer is a significant global health issue, and the diagnosis of breast cancer through imaging remains challenging. Mammography images are characterized by extremely high resolution, while lesions often occupy only a small portion of the image. Down-sampling in neural networks can easily lead to the loss of microcalcifications or subtle structures. To tackle these challenges, we propose a Context Clustering based triple information fusion framework. First, in comparison to CNNs or transformers, we observe that Context clustering methods are (1) more computationally efficient and (2) better at associating structural or pathological features. This makes them particularly well-suited for mammography in clinical settings. Next, we propose a triple information fusion mechanism that integrates global, feature-based local, and patch-based local information. The proposed approach is rigorously evaluated on two public datasets, Vindr-Mammo and CBIS-DDSM, using five independent data splits to ensure statistical robustness. Our method achieves an AUC of 0.828 \pm 0.020 on Vindr-Mammo and 0.805 \pm 0.020 on CBIS-DDSM, outperforming the second best method by 3.5% and 2.5%, respectively. These improvements are statistically significant (p<0.05), highlighting the advantages of the Context Clustering Network with triple information fusion. Overall, our Context Clustering framework demonstrates strong potential as a scalable and cost-effective solution for large-scale mammography screening, enabling more efficient and accurate breast cancer detection. Access to our method is available at https://github.com/Sohyu1/Mammo-Clustering.

q-bio.TO↗

arXiv2025

RT-DEMT: A hybrid real-time acupoint detection model combining mamba and transformer

Traditional Chinese acupuncture methods often face controversy in clinical practice due to their high subjectivity. Additionally, current intelligent-assisted acupuncture systems have two major limitations: slow acupoint localization speed and low accuracy. To address these limitations, a new method leverages the excellent inference efficiency of the state-space model Mamba, while retaining the advantages of the attention mechanism in the traditional DETR architecture, to achieve efficient global information integration and provide high-quality feature information for acupoint localization tasks. Furthermore, by employing the concept of residual likelihood estimation, it eliminates the need for complex upsampling processes, thereby accelerating the acupoint localization task. Our method achieved state-of-the-art (SOTA) accuracy on a private dataset of acupoints on the human back, with an average Euclidean distance pixel error (EPE) of 7.792 and an average time consumption of 10.05 milliseconds per localization task. Compared to the second-best algorithm, our method improved both accuracy and speed by approximately 14\%. This significant advancement not only enhances the efficacy of acupuncture treatment but also demonstrates the commercial potential of automated acupuncture robot systems. Access to our method is available at https://github.com/Sohyu1/RT-DEMT

cs.CV↗

arXiv2025

Synthetic Poisoning Attacks: The Impact of Poisoned MRI Image on U-Net Brain Tumor Segmentation

Deep learning-based medical image segmentation models, such as U-Net, rely on high-quality annotated datasets to achieve accurate predictions. However, the increasing use of generative models for synthetic data augmentation introduces potential risks, particularly in the absence of rigorous quality control. In this paper, we investigate the impact of synthetic MRI data on the robustness and segmentation accuracy of U-Net models for brain tumor segmentation. Specifically, we generate synthetic T1-contrast-enhanced (T1-Ce) MRI scans using a GAN-based model with a shared encoding-decoding framework and shortest-path regularization. To quantify the effect of synthetic data contamination, we train U-Net models on progressively "poisoned" datasets, where synthetic data proportions range from 16.67% to 83.33%. Experimental results on a real MRI validation set reveal a significant performance degradation as synthetic data increases, with Dice coefficients dropping from 0.8937 (33.33% synthetic) to 0.7474 (83.33% synthetic). Accuracy and sensitivity exhibit similar downward trends, demonstrating the detrimental effect of synthetic data on segmentation robustness. These findings underscore the importance of quality control in synthetic data integration and highlight the risks of unregulated synthetic augmentation in medical image analysis. Our study provides critical insights for the development of more reliable and trustworthy AI-driven medical imaging systems.

eess.IV↗

arXiv2024

Mammo-Clustering: A Multi-views Tri-level Information Fusion Context Clustering Framework for Localization and Classification in Mammography

Breast cancer is a significant global health issue, and the diagnosis of breast imaging has always been challenging. Mammography images typically have extremely high resolution, with lesions occupying only a very small area. Down-sampling in neural networks can easily lead to the loss of microcalcifications or subtle structures, making it difficult for traditional neural network architectures to address these issues. To tackle these challenges, we propose a Context Clustering Network with triple information fusion. Firstly, compared to CNNs or transformers, we find that Context clustering methods (1) are more computationally efficient and (2) can more easily associate structural or pathological features, making them suitable for the clinical tasks of mammography. Secondly, we propose a triple information fusion mechanism that integrates global information, feature-based local information, and patch-based local information. The proposed approach is rigorously evaluated on two public datasets, Vindr-Mammo and CBIS-DDSM, using five independent splits to ensure statistical robustness. Our method achieves an AUC of 0.828 on Vindr-Mammo and 0.805 on CBIS-DDSM, outperforming the next best method by 3.1% and 2.4%, respectively. These improvements are statistically significant (p<0.05), underscoring the benefits of Context Clustering Network with triple information fusion. Overall, our Context Clustering framework demonstrates strong potential as a scalable and cost-effective solution for large-scale mammography screening, enabling more efficient and accurate breast cancer detection. Access to our method is available at https://github.com/Sohyu1/Mammo_Clustering.

cs.CV↗

arXiv2023

INR-LDDMM: Fluid-based Medical Image Registration Integrating Implicit Neural Representation and Large Deformation Diffeomorphic Metric Mapping

We propose a fluid-based registration framework of medical images based on implicit neural representation. By integrating implicit neural representation and Large Deformable Diffeomorphic Metric Mapping (LDDMM), we employ a Multilayer Perceptron (MLP) as a velocity generator while optimizing velocity and image similarity. Moreover, we adopt a coarse-to-fine approach to address the challenge of deformable-based registration methods dropping into local optimal solutions, thus aiding the management of significant deformations in medical image registration. Our algorithm has been validated on a paired CT-CBCT dataset of 50 patients,taking the Dice coefficient of transferred annotations as an evaluation metric. Compared to existing methods, our approach achieves the state-of-the-art performance.

eess.IV↗

arXiv2023

XTransCT: Ultra-Fast Volumetric CT Reconstruction using Two Orthogonal X-Ray Projections for Image-guided Radiation Therapy via a Transformer Network

Computed tomography (CT) scans offer a detailed, three-dimensional representation of patients' internal organs. However, conventional CT reconstruction techniques necessitate acquiring hundreds or thousands of x-ray projections through a complete rotational scan of the body, making navigation or positioning during surgery infeasible. In image-guided radiation therapy, a method that reconstructs ultra-sparse X-ray projections into CT images, we can exploit the substantially reduced radiation dose and minimize equipment burden for localization and navigation. In this study, we introduce a novel Transformer architecture, termed XTransCT, devised to facilitate real-time reconstruction of CT images from two-dimensional X-ray images. We assess our approach regarding image quality and structural reliability using a dataset of fifty patients, supplied by a hospital, as well as the larger public dataset LIDC-IDRI, which encompasses thousands of patients. Additionally, we validated our algorithm's generalizability on the LNDb dataset. Our findings indicate that our algorithm surpasses other methods in image quality, structural precision, and generalizability. Moreover, in comparison to previous 3D convolution-based approaches, we note a substantial speed increase of approximately 300 %, achieving 44 ms per 3D image reconstruction.

eess.IV↗

arXiv2023

Three-Dimensional Medical Image Fusion with Deformable Cross-Attention

Multimodal medical image fusion plays an instrumental role in several areas of medical image processing, particularly in disease recognition and tumor detection. Traditional fusion methods tend to process each modality independently before combining the features and reconstructing the fusion image. However, this approach often neglects the fundamental commonalities and disparities between multimodal information. Furthermore, the prevailing methodologies are largely confined to fusing two-dimensional (2D) medical image slices, leading to a lack of contextual supervision in the fusion images and subsequently, a decreased information yield for physicians relative to three-dimensional (3D) images. In this study, we introduce an innovative unsupervised feature mutual learning fusion network designed to rectify these limitations. Our approach incorporates a Deformable Cross Feature Blend (DCFB) module that facilitates the dual modalities in discerning their respective similarities and differences. We have applied our model to the fusion of 3D MRI and PET images obtained from 660 patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Through the application of the DCFB module, our network generates high-quality MRI-PET fusion images. Experimental results demonstrate that our method surpasses traditional 2D image fusion methods in performance metrics such as Peak Signal to Noise Ratio (PSNR) and Structural Similarity Index Measure (SSIM). Importantly, the capacity of our method to fuse 3D images enhances the information available to physicians and researchers, thus marking a significant step forward in the field. The code will soon be available online.

eess.IV↗

arXiv2023

QUIZ: An Arbitrary Volumetric Point Matching Method for Medical Image Registration

Rigid pre-registration involving local-global matching or other large deformation scenarios is crucial. Current popular methods rely on unsupervised learning based on grayscale similarity, but under circumstances where different poses lead to varying tissue structures, or where image quality is poor, these methods tend to exhibit instability and inaccuracies. In this study, we propose a novel method for medical image registration based on arbitrary voxel point of interest matching, called query point quizzer (QUIZ). QUIZ focuses on the correspondence between local-global matching points, specifically employing CNN for feature extraction and utilizing the Transformer architecture for global point matching queries, followed by applying average displacement for local image rigid transformation. We have validated this approach on a large deformation dataset of cervical cancer patients, with results indicating substantially smaller deviations compared to state-of-the-art methods. Remarkably, even for cross-modality subjects, it achieves results surpassing the current state-of-the-art.

cs.CV↗

arXiv2022

A Hybrid Deep Feature-Based Deformable Image Registration Method for Pathology Images

Pathologists need to combine information from differently stained pathology slices for accurate diagnosis. Deformable image registration is a necessary technique for fusing multi-modal pathology slices. This paper proposes a hybrid deep feature-based deformable image registration framework for stained pathology samples. We first extract dense feature points via the detector-based and detector-free deep learning feature networks and perform points matching. Then, to further reduce false matches, an outlier detection method combining the isolation forest statistical model and the local affine correction model is proposed. Finally, the interpolation method generates the deformable vector field for pathology image registration based on the above matching points. We evaluate our method on the dataset of the Non-rigid Histology Image Registration (ANHIR) challenge, which is co-organized with the IEEE ISBI 2019 conference. Our technique outperforms the traditional approaches by 17% with the Average-Average registration target error (rTRE) reaching 0.0034. The proposed method achieved state-of-the-art performance and ranked 1st in evaluating the test dataset. The proposed hybrid deep feature-based registration method can potentially become a reliable method for pathology image registration.

eess.IV↗