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Chunhao Wang

Publications and source records attributed to Chunhao Wang.

At least 19 recordsLinked to original sources

Sparse Hamiltonian simulation with optimal dependence on the maximum column Euclidean norm

We give a quantum algorithm for simulating a $d$-sparse Hermitian Hamiltonian $H$, assuming a known upper bound $Λ$ on its maximum column Euclidean norm $\|H\|_{1\to2}$. For $tΛ\ge1/2$, simulation with operator-norm error $ε$ uses \[ O\!\left(tΛ\sqrt d+\sqrt d\log(2/ε)\right) \] sparse-oracle queries. This removes the subpolynomial overhead in Low's algorithm [STOC 2019], replacing it with an additive logarithmic precision term. For $d>1$ and $tΛ\ge\log(2/ε)$, the bound matches the worst-case lower bound. A known spectral-norm upper bound may also be used in place of $Λ$. The number of 1- and 2-qubit gates is linear in the query scale, up to oracle costs and polynomial overhead in the input bit lengths and logarithmic precision parameters. As applications, we obtain $O(κ\sqrt d\,\mathrm{polylog}(κ/ε))$ queries for solving $d$-sparse quantum linear systems with $\|A\|\le1$ and $\|A^{-1}\|\leκ$, under standard sparse and state-preparation access. We also give a gate-efficient implementation of black-box unitaries with at most $d$ nonzero entries per row and column using $O(\sqrt d\log(2/ε))$ queries, given sparse access to the unitary and its adjoint. At constant error, the query bound is optimal and yields $Θ(\sqrt N)$ queries for arbitrary $N\times N$ unitaries, resolving the open question on black-box unitary implementation posed by Berry and Childs [QIC 2012].

quant-ph↗

Quantum Fine-Grained Lower Bounds for SetDisjointness via Sub-Linear Reductions from 3SUM

In classical fine-grained complexity, the 3SUM Conjecture is used to prove a variety of conditional lower bounds on data structure and graph problems via an initial reduction to the SetDisjointness problem. However, there is an $\tilde{O}(n)$-time quantum algorithm for 3SUM and a direct application of Grover's algorithm to SetDisjointness queries beats the state-of-the-art classical conditional bound by Kopelowitz, Pettie, and Porat (SODA 2016); this shows that these classical bounds do not apply in the quantum setting. Thus establishing analogous conditional lower bounds in the quantum setting requires applying the quantum 3SUM Conjecture to a \emph{quantum} fine-grained reduction from 3SUM to SetDisjointness. We give the first sub-linear time quantum reductions from 3SUM to online SetDisjointness. Via our reduction, the quantum 3SUM conjecture implies a $p + 2q \geqslant 1$ tradeoff bound for quantum SetDisjointness algorithms with $O(N^p)$ preprocessing time and $O(N^q)$ query time. We also give an analogous reduction from 3XOR. These results are derived from a general framework for fine-grained reductions to SetDisjointness which applies to any Abelian 3-Orthogonal Array (3OA) problem with suitable almost-linear hash functions.

cs.CC↗

Optimizing VLP-aligned Multimodal Intent Representation with Correct Visual Instantiation for Zero-Shot Composed Image Retrieval

ZS-CIR aims to retrieve a target image from a reference image and a modification text without paired supervision, typically by encoding composed queries as text-dominant representations within the image-text matching space of VLPs. However, queries reconstructed by visual pseudo-word learning or MLLM-based target reasoning often deviate from the native VLP representation space due to reference noise and coarse text fusion in the former, and verbose, weakly visually grounded descriptions in the latter. In this paper, we propose a unified ZS-CIR framework (named VMIR-CVI) to reconstruct multimodal composite queries from two complementary perspectives for optimizing VLP-compatible multimodal intent representation. First, it reasons and converts the multimodal intent into a unified textual description, aligning with the native text space of the VLP backbones to produce more retrieval-compatible textual queries. Second, it reconstructs the query representation with correctly decoupled visual instance cues, reducing reference noise while preserving target-relevant content. Specifically, a VLP-aligned Multimodal Intent Reasoning (VMIR) module injects few-shot VLP-style exemplars into chain-of-thought prompts, guiding the MLLM to generate target-consistent intent queries. A Training-free Visual Instance Disentanglement (TVID) module decouples fine-grained visual instances from global reference features without additional optimization. Finally, a lightweight Hybrid-modal Intent Alignment and Fusion (HIAF) module integrates the reasoned textual intent and disentangled visual cues into a unified hybrid-modal representation for robust ZS-CIR. Extensive experiments on three CIR benchmarks, namely CIRR, CIRCO and FashionIQ, show that VMIR-CVI significantly outperforms existing baselines and achieves new state-of-the-art performance. Code and trained models will be publicly released.

cs.IR↗

Query-optimal quantum simulation of Lindblad evolution

For the problem of simulating Lindblad evolution for time $t$ to precision $ε$, Hamiltonian simulation provides an additive query lower bound, informally, $Ω(t + \mathrm{polylog}(1/ε))$. However, the best previously known algorithms for general Lindblad simulation achieve a multiplicative upper bound, informally, $\mathcal{O}(t\,\mathrm{polylog}(1/ε))$, in query complexity. It has remained open whether this multiplicative dependence is necessary. In this paper, we close the gap in query complexity by giving an algorithm with optimal additive dependence on evolution time and precision in the block-encoding model. Our approach uses the transducer framework to reduce the query cost of composing first-order approximations to the evolution channel, together with linear combinations of reuse circuits of different lengths to suppress catalyst-removal error. We further achieve nearly optimal gate complexity in evolution time and precision through history compression and an efficient implementation of the query-free part of the transducer using operation reordering and linear combinations of unitaries, while preserving the optimal query complexity.

quant-ph↗

Quantum Speedups for Sampling and Non-convex Optimization with Stochastic Oracles

We present quantum speedups for sampling from distributions of the form $π\propto e^{-f}$ on $\mathbb{R}^d$. We consider two stochastic oracle models: a stochastic gradient oracle, where $f=\frac{1}{n}\sum_{i=1}^n f_i $ and component gradients $\{\nabla f_i\}_{i \in [n]}$ are available, and a stochastic evaluation oracle, where only noisy values of $f$ are available. Our framework accelerates classical stochastic Langevin Monte Carlo (LMC) and Hamiltonian Monte Carlo (HMC) algorithms by replacing stochastic gradient estimators with variance-controlled quantum mean estimation and gradient estimation subroutines. Unlike quantum walk based approaches, our algorithms do not require reversibility or exact gradients, and they preserve the structure of the underlying Markov chain. In the finite-sum setting, quantum mean estimation combined with classical variance-reduction techniques improves the stochastic gradient-query complexity for the approximate sampling task. In the stochastic zeroth-order setting, we develop gradient estimators robust to noisy function evaluations, yielding improved evaluation complexity for LMC and HMC. These results apply to strongly log-concave and/or non-log-concave distributions satisfying a log-Sobolev inequality, with convergence guarantees in Wasserstein distance and Kullback--Leibler divergence. We also show that faster sampling methods lead to quantum speedups for optimization, including for non-smooth and approximately convex objectives.

quant-ph↗

MCoT-MVS: Multi-level Vision Selection by Multi-modal Chain-of-Thought Reasoning for Composed Image Retrieval

Composed Image Retrieval (CIR) aims to retrieve target images based on a reference image and modified texts. However, existing methods often struggle to extract the correct semantic cues from the reference image that best reflect the user's intent under textual modification prompts, resulting in interference from irrelevant visual noise. In this paper, we propose a novel Multi-level Vision Selection by Multi-modal Chain-of-Thought Reasoning (MCoT-MVS) for CIR, integrating attention-aware multi-level vision features guided by reasoning cues from a multi-modal large language model (MLLM). Specifically, we leverage an MLLM to perform chain-of-thought reasoning on the multimodal composed input, generating the retained, removed, and target-inferred texts. These textual cues subsequently guide two reference visual attention selection modules to selectively extract discriminative patch-level and instance-level semantics from the reference image. Finally, to effectively fuse these multi-granular visual cues with the modified text and the imagined target description, we design a weighted hierarchical combination module to align the composed query with target images in a unified embedding space. Extensive experiments on two CIR benchmarks, namely CIRR and FashionIQ, demonstrate that our approach consistently outperforms existing methods and achieves new state-of-the-art performance. Code and trained models are publicly released.

cs.CV↗

On the (Classical and Quantum) Fine-Grained Complexity of Approximate CVP and Max-Cut

We show a linear-size reduction from gap Max-2-Lin(2) (a generalization of the gap $\mathrm{Max}$-$\mathrm{Cut}$ problem) to $γ\text{-}\mathrm{CVP}_p$ for $γ= \mathrm{O}(1)$ and finite $p\geq 1$, as well as a no-go theorem against poly-sized non-adaptive quantum reductions from $k$-SAT to $\mathrm{CVP}_2$. This implies three headline results: (i) Faster algorithms for $γ\text{-}\mathrm{CVP}$ are also faster algorithms for Max-2-Lin(2) and Max-Cut. Depending on the approximation regime, even a $2^{0.78n}$-time or $2^{0.3n}$-time algorithm would improve upon the state-of-the-art algorithm such as Williams' 2004 algorithm [Theoretical Computer Science 2005] or Arora et al.'s 2010 algorithm [Journal of the ACM 2015]. This provides evidence that $γ\text{-}\mathrm{CVP}$ for $γ=\mathrm{O}(1)$ requires exponential time, improving upon the previous lower-bound for $γ<3$ by Bennett et al. [arxiv:1704.03928]. (ii) A new almost $2^{(1/2+\varepsilon/4ς+o(1))n}$-time classical algorithm and a new almost $2^{(1/3+\varepsilon/6ς+o(1))n}$-time quantum algorithm for $(1-\varepsilon,1-ς)$-gap Max-2-Lin(2). This algorithm is faster than the algorithm of Arora et al., as well as the algorithm of Williams, and the algorithm of Manurangsi and Trevisan [arxiv:1807.09898] when $c_0 \varepsilon<ς 0$, it must be via an adaptive quantum reduction unless $\mathrm{NP} \subseteq \mathrm{pr}\text{-}\mathrm{QSZK}$. This illuminates some difficulties in characterizing the hardness of approximate CSPs and shows that the post-quantum security of lattice-based cryptography likely cannot be supported by QSETH.

cs.CC↗

Quantum Regression Theory and Efficient Computation of Response Functions for Non-Markovian Open Systems

Linear response functions are a cornerstone concept in physics as they enable efficient estimation of many dynamical properties. In addition to predicting dynamics of observables under perturbations without resimulating the system, these response functions lead to electric conductivity, magnetic susceptibility, dielectric constants, etc. Estimating two-time correlation functions is a key ingredient of measuring linear response functions. However, for open quantum systems, simulating the reduced density operator with a quantum master equation only yields \emph{one-point} observables and is insufficient for this task. In this paper, we develop a memoryless, system-only formulation of two-point correlations for open quantum systems that extends the standard quantum regression theorem (QRT) beyond the Markov limit. We further incorporate the spectral property of the bath and express the time propagators in the response function as the memoryless generators in Lindblad-type forms. The resulting expressions recast the total response function into evolutions generated by time-dependent Hamiltonian and Lindblad primitives together with the more challenging propagation of commutators and anti-commutators. In addition to the derivation of the new QRT, we present quantum algorithms for these primitives and obtain an estimator for two-time correlations whose cost scales poly-logarithmically in the system dimension and $1/ε^{1.25}$ in the target accuracy $ε$. The framework removes the separability (Born-Markov) assumption and offers a pathway to efficient computation of nonequilibrium properties from open quantum systems.

quant-ph↗

A Dual Radiomic and Dosiomic Filtering Technique for Locoregional Radiation Pneumonitis Prediction in Breast Cancer Patients

Purpose: Radiation pneumonitis (RP) is a serious complication of intensity-modulated radiation therapy (IMRT) for breast cancer patients, underscoring the need for precise and explainable predictive models. This study presents an Explainable Dual-Omics Filtering (EDOF) model that integrates spatially localized dosiomic and radiomic features for voxel-level RP prediction. Methods: A retrospective cohort of 72 breast cancer patients treated with IMRT was analyzed, including 28 who developed RP. The EDOF model consists of two components: (1) dosiomic filtering, which extracts local dose intensity and spatial distribution features from planning dose maps, and (2) radiomic filtering, which captures texture-based features from pre-treatment CT scans. These features are jointly analyzed using the Explainable Boosting Machine (EBM), a transparent machine learning model that enables feature-specific risk evaluation. Model performance was assessed using five-fold cross-validation, reporting area under the curve (AUC), sensitivity, and specificity. Feature importance was quantified by mean absolute scores, and Partial Dependence Plots (PDPs) were used to visualize nonlinear relationships between RP risk and dual-omic features. Results: The EDOF model achieved strong predictive performance (AUC = 0.95 +- 0.01; sensitivity = 0.81 +- 0.05). The most influential features included dosiomic Intensity Mean, dosiomic Intensity Mean Absolute Deviation, and radiomic SRLGLE. PDPs revealed that RP risk increases beyond 5 Gy and rises sharply between 10-30 Gy, consistent with clinical dose thresholds. SRLGLE also captured structural heterogeneity linked to RP in specific lung regions. Conclusion: The EDOF framework enables spatially resolved, explainable RP prediction and may support personalized radiation planning to mitigate pulmonary toxicity.

physics.med-ph↗

Time-Dependent Hamiltonian Simulation via Time-Independent Dynamics in a Larger Space

In this paper, we present a proof-of-concept quantum algorithm for simulating time-dependent Hamiltonian evolution by reducing the problem to simulating a time-independent Hamiltonian in a larger space using a discrete clock Hamiltonian construction. A similar construction was first explored for this simulation problem by Watkins, Wiebe, Roggero, and Lee [PRX Quantum, 2024]. Our algorithm improves upon their work in terms of the dependence on evolution time and precision. In addition, the complexity matches the state-of-the-art simulation algorithms using other approaches. To achieve this improvement, we use Duhamel's principle to treat the clock and system Hamiltonians separately and exploit properties of Gaussian quadrature to reduce the simulation cost. Our approach demonstrates that time-dependent Hamiltonian simulation can be as efficient in a simpler framework and hence provides a new angle to model and simulate time-dependent systems.

quant-ph↗

Analysis of the 2024 BraTS Meningioma Radiotherapy Planning Automated Segmentation Challenge

The 2024 Brain Tumor Segmentation Meningioma Radiotherapy (BraTS-MEN-RT) challenge aimed to advance automated segmentation algorithms using the largest known multi-institutional dataset of 750 radiotherapy planning brain MRIs with expert-annotated target labels for patients with intact or postoperative meningioma that underwent either conventional external beam radiotherapy or stereotactic radiosurgery. Each case included a defaced 3D post-contrast T1-weighted radiotherapy planning MRI in its native acquisition space, accompanied by a single-label "target volume" representing the gross tumor volume (GTV) and any at-risk post-operative site. Target volume annotations adhered to established radiotherapy planning protocols, ensuring consistency across cases and institutions, and were approved by expert neuroradiologists and radiation oncologists. Six participating teams developed, containerized, and evaluated automated segmentation models using this comprehensive dataset. Team rankings were assessed using a modified lesion-wise Dice Similarity Coefficient (DSC) and 95% Hausdorff Distance (95HD). The best reported average lesion-wise DSC and 95HD was 0.815 and 26.92 mm, respectively. BraTS-MEN-RT is expected to significantly advance automated radiotherapy planning by enabling precise tumor segmentation and facilitating tailored treatment, ultimately improving patient outcomes. We describe the design and results from the BraTS-MEN-RT challenge.

cs.CV↗

A Voxel-Wise Uncertainty-Guided Framework for Glioma Segmentation Using Spherical Projection-Based U-Net and Localized Refinement in Multi-Parametric MRI

Purpose: Accurate segmentation of glioma subregions in multi-parametric MRI (MP-MRI) is essential for diagnosis and treatment planning but remains challenging due to tumor heterogeneity and ambiguous boundaries. This study proposes an uncertainty-guided hybrid framework integrating spherical projection-based 2D modeling with targeted 3D refinement to enhance segmentation accuracy and interpretability. Methods: Using the BraTS2020 dataset (369 patients, four-modality MP-MRI), three 2D U-Nets were trained to segment enhancing tumor (ET), tumor core (TC), and whole tumor (WT). Voxel-wise uncertainty was quantified via a spherical projection-based 2D nnU-Net, capturing prediction variance across deformed inputs. A 3D sliding window was used to identify high-uncertainty regions, which were refined using a dedicated 3D nnU-Net. Final outputs combined 2D and 3D predictions through a weighted fusion optimized via Particle Swarm Optimization. Results: The proposed method outperformed standalone 2D and 3D baselines, achieving Dice scores of 0.8124 (ET), 0.7499 (TC), and 0.9055 (WT), with consistent gains in sensitivity and visual coherence. Conclusion: This work presents a novel uncertainty-aware segmentation strategy that adaptively integrates 2D and 3D modeling. By focusing refinement on ambiguous regions, it improves both efficiency and accuracy, offering broad applicability to precision neuro-oncology and other high-stakes medical imaging tasks.

physics.med-ph↗

An Explainable Neural Radiomic Sequence Model with Spatiotemporal Continuity for Quantifying 4DCT-based Pulmonary Ventilation

Accurate evaluation of regional lung ventilation is essential for the management and treatment of lung cancer patients, supporting assessments of pulmonary function, optimization of therapeutic strategies, and monitoring of treatment response. Currently, ventilation scintigraphy using nuclear medicine techniques is widely employed in clinical practice; however, it is often time-consuming, costly, and entails additional radiation exposure. In this study, we propose an explainable neural radiomic sequence model to identify regions of compromised pulmonary ventilation based on four-dimensional computed tomography (4DCT). A cohort of 45 lung cancer patients from the VAMPIRE dataset was analyzed. For each patient, lung volumes were segmented from 4DCT, and voxel-wise radiomic features (56-dimensional) were extracted across the respiratory cycle to capture local intensity and texture dynamics, forming temporal radiomic sequences. Ground truth ventilation defects were delineated voxel-wise using Galligas-PET and DTPA-SPECT. To identify compromised regions, we developed a temporal saliency-enhanced explainable long short-term memory (LSTM) network trained on the radiomic sequences. Temporal saliency maps were generated to highlight key features contributing to the model's predictions. The proposed model demonstrated robust performance, achieving average (range) Dice similarity coefficients of 0.78 (0.74-0.79) for 25 PET cases and 0.78 (0.74-0.82) for 20 SPECT cases. The temporal saliency map explained three key radiomic sequences in ventilation quantification: during lung exhalation, compromised pulmonary function region typically exhibits (1) an increasing trend of intensity and (2) a decreasing trend of homogeneity, in contrast to healthy lung tissue.

physics.med-ph↗

Analysis of the MICCAI Brain Tumor Segmentation -- Metastases (BraTS-METS) 2025 Lighthouse Challenge: Brain Metastasis Segmentation on Pre- and Post-treatment MRI

Despite continuous advancements in cancer treatment, brain metastatic disease remains a significant complication of primary cancer and is associated with an unfavorable prognosis. One approach for improving diagnosis, management, and outcomes is to implement algorithms based on artificial intelligence for the automated segmentation of both pre- and post-treatment MRI brain images. Such algorithms rely on volumetric criteria for lesion identification and treatment response assessment, which are still not available in clinical practice. Therefore, it is critical to establish tools for rapid volumetric segmentations methods that can be translated to clinical practice and that are trained on high quality annotated data. The BraTS-METS 2025 Lighthouse Challenge aims to address this critical need by establishing inter-rater and intra-rater variability in dataset annotation by generating high quality annotated datasets from four individual instances of segmentation by neuroradiologists while being recorded on video (two instances doing "from scratch" and two instances after AI pre-segmentation). This high-quality annotated dataset will be used for testing phase in 2025 Lighthouse challenge and will be publicly released at the completion of the challenge. The 2025 Lighthouse challenge will also release the 2023 and 2024 segmented datasets that were annotated using an established pipeline of pre-segmentation, student annotation, two neuroradiologists checking, and one neuroradiologist finalizing the process. It builds upon its previous edition by including post-treatment cases in the dataset. Using these high-quality annotated datasets, the 2025 Lighthouse challenge plans to test benchmark algorithms for automated segmentation of pre-and post-treatment brain metastases (BM), trained on diverse and multi-institutional datasets of MRI images obtained from patients with brain metastases.

q-bio.OT↗

BraTS-PEDs: Results of the Multi-Consortium International Pediatric Brain Tumor Segmentation Challenge 2023

Pediatric central nervous system tumors are the leading cause of cancer-related deaths in children. The five-year survival rate for high-grade glioma in children is less than 20%. The development of new treatments is dependent upon multi-institutional collaborative clinical trials requiring reproducible and accurate centralized response assessment. We present the results of the BraTS-PEDs 2023 challenge, the first Brain Tumor Segmentation (BraTS) challenge focused on pediatric brain tumors. This challenge utilized data acquired from multiple international consortia dedicated to pediatric neuro-oncology and clinical trials. BraTS-PEDs 2023 aimed to evaluate volumetric segmentation algorithms for pediatric brain gliomas from magnetic resonance imaging using standardized quantitative performance evaluation metrics employed across the BraTS 2023 challenges. The top-performing AI approaches for pediatric tumor analysis included ensembles of nnU-Net and Swin UNETR, Auto3DSeg, or nnU-Net with a self-supervised framework. The BraTSPEDs 2023 challenge fostered collaboration between clinicians (neuro-oncologists, neuroradiologists) and AI/imaging scientists, promoting faster data sharing and the development of automated volumetric analysis techniques. These advancements could significantly benefit clinical trials and improve the care of children with brain tumors.

eess.IV↗

Embedding Radiomics into Vision Transformers for Multimodal Medical Image Classification

Background: Deep learning has significantly advanced medical image analysis, with Vision Transformers (ViTs) offering a powerful alternative to convolutional models by modeling long-range dependencies through self-attention. However, ViTs are inherently data-intensive and lack domain-specific inductive biases, limiting their applicability in medical imaging. In contrast, radiomics provides interpretable, handcrafted descriptors of tissue heterogeneity but suffers from limited scalability and integration into end-to-end learning frameworks. In this work, we propose the Radiomics-Embedded Vision Transformer (RE-ViT) that combines radiomic features with data-driven visual embeddings within a ViT backbone. Purpose: To develop a hybrid RE-ViT framework that integrates radiomics and patch-wise ViT embeddings through early fusion, enhancing robustness and performance in medical image classification. Methods: Following the standard ViT pipeline, images were divided into patches. For each patch, handcrafted radiomic features were extracted and fused with linearly projected pixel embeddings. The fused representations were normalized, positionally encoded, and passed to the ViT encoder. A learnable [CLS] token aggregated patch-level information for classification. We evaluated RE-ViT on three public datasets (including BUSI, ChestXray2017, and Retinal OCT) using accuracy, macro AUC, sensitivity, and specificity. RE-ViT was benchmarked against CNN-based (VGG-16, ResNet) and hybrid (TransMed) models. Results: RE-ViT achieved state-of-the-art results: on BUSI, AUC=0.950+/-0.011; on ChestXray2017, AUC=0.989+/-0.004; on Retinal OCT, AUC=0.986+/-0.001, which outperforms other comparison models. Conclusions: The RE-ViT framework effectively integrates radiomics with ViT architectures, demonstrating improved performance and generalizability across multimodal medical image classification tasks.

physics.med-ph↗

Toward end-to-end quantum simulation for protein dynamics

Modeling and simulating the protein folding process overall remains a grand challenge in computational biology. We systematically investigate end-to-end quantum algorithms for simulating various protein dynamics with effects, such as mechanical forces or stochastic noises. A major focus is the read-in of system settings for simulation, for which we discuss (i) efficient quantum algorithms to prepare initial states--whether for ensemble or single-state simulations, in particular, the first efficient procedure for preparing Gaussian pseudo-random amplitude states, and (ii) the first efficient loading of the connectivity matrices of the protein structure. For the read-out stage, our algorithms estimate a range of classical observables, including energy, low-frequency vibrational modes, density of states, displacement correlations, and optimal control parameters. Between these stages, we simulate the dynamic evolution of the protein system, by using normal mode models--such as Gaussian network models (GNM) and all-atom normal mode models. In addition, we conduct classical numerical experiments focused on accurately estimating the density of states and applying optimal control to facilitate conformational changes. These experiments serve to validate our claims regarding potential quantum speedups. Overall, our study demonstrates that quantum simulation of protein dynamics represents a robust, end-to-end application for both early-stage and fully fault-tolerant quantum computing.

quant-ph↗

Analysis of the BraTS 2023 Intracranial Meningioma Segmentation Challenge

We describe the design and results from the BraTS 2023 Intracranial Meningioma Segmentation Challenge. The BraTS Meningioma Challenge differed from prior BraTS Glioma challenges in that it focused on meningiomas, which are typically benign extra-axial tumors with diverse radiologic and anatomical presentation and a propensity for multiplicity. Nine participating teams each developed deep-learning automated segmentation models using image data from the largest multi-institutional systematically expert annotated multilabel multi-sequence meningioma MRI dataset to date, which included 1000 training set cases, 141 validation set cases, and 283 hidden test set cases. Each case included T2, FLAIR, T1, and T1Gd brain MRI sequences with associated tumor compartment labels delineating enhancing tumor, non-enhancing tumor, and surrounding non-enhancing FLAIR hyperintensity. Participant automated segmentation models were evaluated and ranked based on a scoring system evaluating lesion-wise metrics including dice similarity coefficient (DSC) and 95% Hausdorff Distance. The top ranked team had a lesion-wise median dice similarity coefficient (DSC) of 0.976, 0.976, and 0.964 for enhancing tumor, tumor core, and whole tumor, respectively and a corresponding average DSC of 0.899, 0.904, and 0.871, respectively. These results serve as state-of-the-art benchmarks for future pre-operative meningioma automated segmentation algorithms. Additionally, we found that 1286 of 1424 cases (90.3%) had at least 1 compartment voxel abutting the edge of the skull-stripped image edge, which requires further investigation into optimal pre-processing face anonymization steps.

eess.IV↗