arXiv subjects

Claude Renaux

Publications and source records attributed to Claude Renaux.

4 recordsLinked to original sources

arXiv2021

Efficient Multiple Testing Adjustment for Hierarchical Inference

Hierarchical inference in (generalized) regression problems is powerful for finding significant groups or even single covariates, especially in high-dimensional settings where identifiability of the entire regression parameter vector may be ill-posed. The general method proceeds in a fully data-driven and adaptive way from large to small groups or singletons of covariates, depending on the signal strength and the correlation structure of the design matrix. We propose a novel hierarchical multiple testing adjustment that can be used in combination with any significance test for a group of covariates to perform hierarchical inference. Our adjustment passes on the significance level of certain hypotheses that could not be rejected and is shown to guarantee strong control of the familywise error rate. Our method is at least as powerful as a so-called depth-wise hierarchical Bonferroni adjustment. It provides a substantial gain in power over other previously proposed inheritance hierarchical procedures if the underlying alternative hypotheses occur sparsely along a few branches in the tree-structured hierarchy.

stat.ME↗

arXiv2021

Multicarving for high-dimensional post-selection inference

We consider post-selection inference for high-dimensional (generalized) linear models. Data carving (Fithian et al., 2014) is a promising technique to perform this task. However, it suffers from the instability of the model selector and hence, may lead to poor replicability, especially in high-dimensional settings. We propose the multicarve method inspired by multisplitting to improve upon stability and replicability. Furthermore, we extend existing concepts to group inference and illustrate the applicability of the methodology also for generalized linear models.

stat.ME↗

arXiv2020

Group Inference in High Dimensions with Applications to Hierarchical Testing

High-dimensional group inference is an essential part of statistical methods for analysing complex data sets, including hierarchical testing, tests of interaction, detection of heterogeneous treatment effects and inference for local heritability. Group inference in regression models can be measured with respect to a weighted quadratic functional of the regression sub-vector corresponding to the group. Asymptotically unbiased estimators of these weighted quadratic functionals are constructed and a novel procedure using these estimators for inference is proposed. We derive its asymptotic Gaussian distribution which enables the construction of asymptotically valid confidence intervals and tests which perform well in terms of length or power. The proposed test is computationally efficient even for a large group, statistically valid for any group size and achieving good power performance for testing large groups with many small regression coefficients. We apply the methodology to several interesting statistical problems and demonstrate its strength and usefulness on simulated and real data.

stat.ME↗

arXiv2019

Hierarchical inference for genome-wide association studies: a view on methodology with software

We provide a view on high-dimensional statistical inference for genome-wide association studies (GWAS). It is in part a review but covers also new developments for meta analysis with multiple studies and novel software in terms of an R-package hierinf. Inference and assessment of significance is based on very high-dimensional multivariate (generalized) linear models: in contrast to often used marginal approaches, this provides a step towards more causal-oriented inference.

stat.AP↗