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Congyuan Duan

Publications and source records attributed to Congyuan Duan.

4 recordsLinked to original sources

Spherical Mixture Integration for Latent Embedding Alignment across Multi-Source Feature Spaces

Multi-institutional electronic health record (Multi-EHR) data have emerged as a powerful resource for developing predictive models to support clinical decisions and for generating reliable real-world evidence. By aggregating information from diverse patient populations and institutions, they enhance the robustness and generalizability of models and findings. However, analyzing multi-EHR remains challenging because disparate institutions rarely map all data elements to common ontologies, and raw EHR codes are often overly granular and institution-specific, fragmenting representations of the same clinical concept. Hence, integrative analysis must overcome two key hurdles: harmonizing codes with the same clinical meaning (synonymy), and aligning institutional feature spaces. To address these challenges, we propose SMILE, a Spherical Mixture Integration for Latent Embedding alignment across multi-source feature spaces, where embeddings from heterogeneous sources serve as privacy-preserving summaries of clinical concepts and sparse relational pairs provide weak supervision. Synonymy is modeled via a mixture of von Mises-Fisher distributions, yielding unified representations of semantically equivalent raw codes. We develop a composite quasi-likelihood estimator with non-asymptotic error bounds for the latent representations and mixture mean directions and consistent synonym-cluster recovery, quantifying the gains from integrating multiple sources and knowledge-graph information. Simulations and a multi-institutional EHR application demonstrate improved alignment and synonym clustering.

stat.ME

Statistical Inference for Matching Decisions via Matrix Completion under Dependent Missingness

This paper studies decision-making and statistical inference for two-sided matching markets via matrix completion. In contrast to the independent sampling assumed in classical matrix completion literature, the observed entries, which arise from past matching data, are constrained by matching capacity. This matching-induced dependence poses new challenges for both estimation and inference in the matrix completion framework. We propose a non-convex algorithm based on Grassmannian gradient descent and establish near-optimal entrywise convergence rates for three canonical mechanisms, i.e., one-to-one matching, one-to-many matching with one-sided random arrival, and two-sided random arrival. To facilitate valid uncertainty quantification and hypothesis testing on matching decisions, we further develop a general debiasing and projection framework for arbitrary linear forms of the reward matrix, deriving asymptotic normality with finite-sample guarantees under matching-induced dependent sampling. Our empirical experiments demonstrate that the proposed approach provides accurate estimation, valid confidence intervals, and efficient evaluation of matching policies.

stat.ME

Regret Minimization and Statistical Inference in Online Decision Making with High-dimensional Covariates

This paper investigates regret minimization, statistical inference, and their interplay in high-dimensional online decision-making based on the sparse linear context bandit model. We integrate the $\varepsilon$-greedy bandit algorithm for decision-making with a hard thresholding algorithm for estimating sparse bandit parameters and introduce an inference framework based on a debiasing method using inverse propensity weighting. Under a margin condition, our method achieves either $O(T^{1/2})$ regret or classical $O(T^{1/2})$-consistent inference, indicating an unavoidable trade-off between exploration and exploitation. If a diverse covariate condition holds, we demonstrate that a pure-greedy bandit algorithm, i.e., exploration-free, combined with a debiased estimator based on average weighting can simultaneously achieve optimal $O(\log T)$ regret and $O(T^{1/2})$-consistent inference. We also show that a simple sample mean estimator can provide valid inference for the optimal policy's value. Numerical simulations and experiments on Warfarin dosing data validate the effectiveness of our methods.

cs.LG

Online Policy Learning and Inference by Matrix Completion

Is it possible to make online decisions when personalized covariates are unavailable? We take a collaborative-filtering approach for decision-making based on collective preferences. By assuming low-dimensional latent features, we formulate the covariate-free decision-making problem as a matrix completion bandit. We propose a policy learning procedure that combines an $\varepsilon$-greedy policy for decision-making with an online gradient descent algorithm for bandit parameter estimation. Our novel two-phase design balances policy learning accuracy and regret performance. For policy inference, we develop an online debiasing method based on inverse propensity weighting and establish its asymptotic normality. Our methods are applied to data from the San Francisco parking pricing project, revealing intriguing discoveries and outperforming the benchmark policy.

stat.ML