arXiv subjects

Corina Andreoiu

Publications and source records attributed to Corina Andreoiu.

4 recordsLinked to original sources

arXiv2026

The 2027-2034 Vision for Nuclear Physics in Canada, with an outlook to 2041

The Canadian subatomic physics community establishes its scientific, and thus funding, priorities through periodic Long-Range Plans (LRP). The community is now putting together a new LRP, which will be in effect from 2027 through 2034, with its scope extending through 2041. As part of this process, the Canadian Institute of Nuclear Physics (CINP) has put together a strategic report, following an extensive consultation process. The report describes the broad and ambitious research program undertaken by the Canadian nuclear physics research community, both onshore and abroad, touching on key questions regarding the origin, evolution, and structure of visible matter in the universe. This document provides a grid of different Canadian nuclear physics projects undertaken now and in the future, and their associated timelines. It concludes with specific recommendations for maximizing Canadian scientific output in nuclear physics.

nucl-ex↗

arXiv2025

Novel Direct Alpha Spectroscopy Technique for $^{225}$Ac Radiopharmaceutical detection in Cancer Cells

Targeted alpha-particle therapy (TAT) employs alpha-emitting radionuclides conjugated to tumor-targeting molecules to deliver localized radiation to cancer cells, showing great promise in treating metastatic cancers. Among these radionuclides, Actinium-225 ($^{225}$Ac, t$_{1/2}$ = 9.9 days) has emerged as a clinically promising candidate. Its decay chain generates four successive alpha emissions, resulting in highly localized and effective cytotoxic damage to cancer cells when delivered to tumor sites. However, the assumption of complete retention of $^{225}$Ac and its radioactive daughters at these target sites is often inaccurate. The nuclear recoil effect can lead to off-target distribution and unintended toxicity. Our results revealed distinct spectral differences between radiolabeled cells and reference samples, demonstrating [$^{225}$Ac]Ac-crown-TATE uptake by AR42J cells. Detection of $^{213}$Po, one of the $^{225}$Ac decay daughters, highlighted partial retention and release of decay products from cells, providing information on intracellular retention and daughter redistribution. Geant4 simulations confirmed the alignment of experimental data with theoretical models, validating the method's accuracy. This study establishes a direct alpha spectroscopy approach for investigating $^{225}$Ac and its daughters' behavior in cells and offers a powerful tool for microdosimetry estimation.

physics.med-ph↗

arXiv2023

Understanding radioactive ion beam production at ISAC through yield measurements and simulations

The high-intensity proton beam of the TRIUMF 500 MeV cyclotron offers unique opportunities to produce rare isotopes by irradiating a variety of targets. In particular, the ISAC (Isotope Separation and ACceleration) facility provides the infrastructure to deliver customized rare ion beams for fundamental research in nuclear physics, astrophysics, material science, and nuclear medicine. A continuous effort is made to develop new radioactive ion beams (RIB) and improve their intensity or purity, properties that depend strongly on the type of target, operating conditions, the ion source, and beam transport efficiency. Yield data and theoretical production rates based on FLUKA and Geant4 simulations are collected in the TRIUMF Isotope Database, providing a valuable resource for RIB development and experiment planning. This paper introduces the newly upgraded TRIUMF Isotope Database and presents examples on how it's resources can be used to plan experiments and understand the origin of certain RIB. In particular we discuss the collection of 155Tb which is an important component of medical isotope research at TRIUMF.

physics.acc-ph↗

arXiv2022

Transuranium isotopes at ISAC/TRIUMF

The production of transuranium isotopes has been demonstrated at the Isotope Separation and ACceleration (ISAC) facility. In particular a laser-ionized $^{239}$Pu beam, extracted from a uranium carbide target, was investigated. The experimental work was complemented by GEANT4 simulations, modelling the impact of secondary particles on the creation of transuranium isotopes through inelastic nuclear reactions. Theoretical production cross sections were derived and compared to experimental results, leading to a discussion on boundary conditions for the release of neptunium and plutonium from ISAC uranium carbide targets.

nucl-ex↗