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Cyrill B. Muratov

Publications and source records attributed to Cyrill B. Muratov.

43 records · Page 3Linked to original sources

Asymptotic properties of ground states of scalar field equations with a vanishing parameter

We study the leading order behaviour of positive solutions of the equation -Δu +\varepsilon u-|u|^{p-2}u+|u|^{q-2}u=0,\qquad x\in\R^N, where $N\ge 3$, $q>p>2$ and when $\varepsilon>0$ is a small parameter. We give a complete characterization of all possible asymptotic regimes as a function of $p$, $q$ and $N$. The behavior of solutions depends sensitively on whether $p$ is less, equal or bigger than the critical Sobolev exponent $p^\ast=\frac{2N}{N-2}$. For $p p^\ast$ the solution asymptotically coincides with the solution of the equation with $\varepsilon=0$. In the most delicate case $p=p^\ast$ the asymptotic behaviour of the solutions is given by a particular solution of the critical Emden--Fowler equation, whose choice depends on $\varepsilon$ in a nontrivial way.

math.AP↗

Self-similarity and long-time behavior of solutions of the diffusion equation with nonlinear absorption and a boundary source

This paper deals with the long-time behavior of solutions of nonlinear reaction-diffusion equations describing formation of morphogen gradients, the concentration fields of molecules acting as spatial regulators of cell differentiation in developing tissues. For the considered class of models, we establish existence of a new type of ultra-singular self-similar solutions. These solutions arise as limits of the solutions of the initial value problem with zero initial data and infinitely strong source at the boundary. We prove existence and uniqueness of such solutions in the suitable weighted energy spaces. Moreover, we prove that the obtained self-similar solutions are the long-time limits of the solutions of the initial value problem with zero initial data and a time-independent boundary source.

math.AP↗

On an isoperimetric problem with a competing non-local term. I. The planar case

This paper is concerned with a study of the classical isoperimetric problem modified by an addition of a non-local repulsive term. We characterize existence, non-existence and radial symmetry of the minimizers as a function of mass in the situation where the non-local term is generated by a kernel given by an inverse power of the distance. We prove that minimizers of this problem exist for sufficiently small masses and are given by disks with prescribed mass below a certain threshold, when the interfacial term in the energy is dominant. At the same time, we prove that minimizers fail to exist for sufficiently large masses due to the tendency of the low energy configuration to split into smaller pieces when the non-local term in the energy is dominant. In the latter regime, we also establish linear scaling of energy with mass suggesting that for large masses low energy configurations consist of many roughly equal size pieces far apart. In the case of slowly decaying kernels we give a complete characterization of the minimizers.

math.AP↗

Self-similar dynamics of morphogen gradients

We discovered a class of self-similar solutions in nonlinear models describing the formation of morphogen gradients, the concentration fields of molecules acting as spatial regulators of cell differention in developing tissues. These models account for diffusion and self-induced degration of locally produced chemical signals. When production starts, the signal concentration is equal to zero throughout the system. We found that in the limit of infinitely large signal production strength the solution of this problem is given by the product of the steady state concentration profile and a function of the diffusion similarity variable. We derived a nonlinear boundary value problem satisfied by this function and used a variational approach to prove that this problem has a unique solution in a natural setting. Using the asymptotic behavior of the solutions established by the analysis, we constructed these solutions numerically by the shooting method. Finally, we demonstrated that the obtained solutions may be easily approximated by simple analytical expressions, thus providing an accurate global characterization of the dynamics in an important class of non-linear models of morphogen gradient formation. Our results illustrate the power of analytical approaches to studying nonlinear models of biophysical processes.

q-bio.QM↗

Droplet phases in non-local Ginzburg-Landau models with Coulomb repulsion in two dimensions

We establish the behavior of the energy of minimizers of non-local Ginzburg-Landau energies with Coulomb repulsion in two space dimensions near the onset of multi-droplet patterns. Under suitable scaling of the background charge density with vanishing surface tension the non-local Ginzburg-Landau energy becomes asymptotically equivalent to a sharp interface energy with screened Coulomb interaction. Near the onset the minimizers of the sharp interface energy consist of nearly identical circular droplets of small size separated by large distances. In the limit the droplets become uniformly distributed throughout the domain. The precise asymptotic limits of the bifurcation threshold, the minimal energy, the droplet radii, and the droplet density are obtained.

nlin.PS↗

Non-meanfield deterministic limits in chemical reaction kinetics far from equilibrium

A general mechanism is proposed by which small intrinsic fluctuations in a system far from equilibrium can result in nearly deterministic dynamical behaviors which are markedly distinct from those realized in the meanfield limit. The mechanism is demonstrated for the kinetic Monte-Carlo version of the Schnakenberg reaction where we identified a scaling limit in which the global deterministic bifurcation picture is fundamentally altered by fluctuations. Numerical simulations of the model are found to be in quantitative agreement with theoretical predictions.

q-bio.QM↗

Noise-driven transition to quasi-deterministic limit cycle dynamics in excitable systems

The effect of small-amplitude noise on excitable systems with large time-scale separation is analyzed. It is found that small random perturbations of the fast excitatory variable result in the onset of a quasi-deterministic limit cycle behavior, absent without noise. The limit cycle is established at a critical value of the amplitude of the noise, and its period is nontrivially determined by the relationship between the noise amplitude and the time scale ratio. It is argued that this effect might provide a mechanism by which the function of biological systems operating in noisy environments can be robustly controlled by the level of the noise.

q-bio.QM↗