arXiv subjects

D. J. G. Pearce

Publications and source records attributed to D. J. G. Pearce.

9 recordsLinked to original sources

arXiv2024

Passive defect driven morphogenesis in nematic membranes

Topological defects are ubiquitous on surfaces with orientational order fields. Here, we study equilibrium states generated by the feedback between geometry and nematic order on fluid membranes with an integer topological defect. When the Frank elastic constants associated with the orientational field dominate, the surfaces spontaneously deform toward an conical shape featuring an aster topological defect at its apex. In the case of vanishing tension this is a solution to the normal force balance. We show that the stability of the surface depends on the balance of the elastic parameters and the phase of the defect. When boundary constraints are introduced, we observe three distinct modes of deformation. These deformation modes take advantage of the way in which splay, twist and bend distortions of the director field can be exchanged on a curved surface. We discuss how these deformation modes are distinguished by their response to the cost of twist distortions and the existence of inverted solutions. Our findings show that fusion of +1/2 topological defect pairs can reduce the total energy of deformable surfaces. Finally, we argue how these results can be relevant for biological systems.

cond-mat.soft↗

arXiv2022

Defect-driven shape transitions in elastic active nematic shells

Active matter is characterized by its ability to induce motion by self-generated stress. In the case of a solid, such motion can lead to shape transformations. The stress-generating components can be anisotropic endowing the material with mesoscopic orientational order. It is currently unknown how the specific postions and orientations of these active constituents influence morphological changes. We study theoretically the effects of imposing topological point defects in the arrangements of the stress-generating components on the morphology of elastic active nematic shells. We show that topological defects of charge +1 are uniquely capable of increasing, reducing or maintaining the intrinsic curvature of the shell. These changes depend on the nature of the active stress and the phase angle of the defect. We apply our theory to experiments conducted on contracting actomyosin sheets. By combining defects of different charges, we can generate shells with arbitrary complexity. We confirm this flexibility by reproducing the shape of the freshwater polyp Hydra, in which topological defects have been associated with morphological features of the animal. In addition to understanding morphogenetic processes, these principles can be applied to the design of programmable active mechanical metamaterials that form the basis of autonomous soft robots.

cond-mat.soft↗

arXiv2021

Orientational correlations in active and passive nematic defects

We investigate the emergence of orientational order among +1/2 disclinations in active nematic liquid crystals. Using a combination of theoretical and experimental methods, we show that +1/2 disclinations have short-range antiferromagnetic alignment, as a consequence of the elastic torques originating from their polar structure. The presence of intermediate -1/2 disclinations, however, turns this interaction from anti-aligning to aligning at scales that are smaller than the typical distance between like-sign defects. No long-range orientational order is observed. Strikingly, these effects are insensitive to material properties and qualitatively similar to what is found for defects in passive nematic liquid crystals.

cond-mat.soft↗

arXiv2020

Chiral edge currents in confined fibrosarcoma cells

During metastatic dissemination, streams of cells collectively migrate through a network of narrow channels within the extracellular matrix, before entering into the blood stream. This strategy is believed to outperform other migration modes, based on the observation that individual cancer cells can take advantage of confinement to switch to an adhesion-independent form of locomotion. Yet, the physical origin of this behaviour has remained elusive and the mechanisms behind the emergence of coherent flows in populations of invading cells under confinement are presently unknown. Here we demonstrate that human fibrosarcoma cells (HT1080) confined in narrow stripe-shaped regions undergo collective migration by virtue of a novel type of topological edge currents, resulting from the interplay between liquid crystalline (nematic) order, microscopic chirality and topological defects. Thanks to a combination of in vitro experiments and theory of active hydrodynamics, we show that, while heterogeneous and chaotic in the bulk of the channel, the spontaneous flow arising in confined populations of HT1080 cells is rectified along the edges, leading to long-ranged collective cell migration, with broken chiral symmetry. These edge currents are fuelled by layers of +1/2 topological defects, orthogonally anchored at the channel walls and acting as local sources of chiral active stress. Our work highlights the profound correlation between confinement and collective migration in multicellular systems and suggests a possible mechanism for the emergence of directed motion in metastatic cancer.

cond-mat.soft↗

arXiv2020

Defect order in active nematics on a curved surface

We investigate the effects of extrinsic curvature on the turbulent behavior of a 2D active nematic confined to the surface of a cylinder. The surface of a cylinder has no intrinsic curvatrue and only extrinsic curvature. A nematic field reacts to the extrinsic curvature by trying to align with the lowest principle curvature, in this case parallel to the long axis of the cylinder. When nematics are sufficiently active, there is a proliferation of defects arising from a bend or splay instability depending on the nature of the active stress. The extrinsic curvature of the cylinder beaks the rotational symmetry of this process, implying that defects are created parallel or perpendicular to the cylinder depending on whether the active nematic is contractile or extensile.

cond-mat.soft↗

arXiv2018

Activity driven orientational order in active nematic liquid crystals on an anisotropic substrate

We investigate the effect of an anisotropic substrate on the turbulent dynamics of a simulated two dimensional active nematic. This is introduced as an anisotropic friction and an effective anisotropic viscosity, with the orientation of the anisotropy being defined by the substrate. In this system we observe the emergence of global nematic order of topological defects that is controlled by the degree of anisotropy in the viscosity and the magnitude of the active stress. No global defect alignment is seen in passive liquid crystals with anisotropic viscosity or friction confirming that ordering is driven by the active stress. We then closely examine the active flow generated by a single defect to show that the kinetic energy of the flow is orientation dependent, resulting in a torque on the defect to align them with the anisotropy in the substrate.

cond-mat.soft↗

arXiv2018

Cellular geometry controls the efficiency of motile sperm aggregates

Teams of cooperating sperm have been found across several vertebrate and invertebrate species, ranging from sperm pairs to massive aggregates containing hundreds of cells. Although the biochemical mechanisms involved in the aggregation process are still unclear, it was found that aggregation can enhance the mobility of the cells, thus offering an advantage during fertilization. Here, we report a thorough computational investigation on the role of cellular geometry in the performance of sperm aggregates. The sperm head is modelled as a persistent random walker characterized by a non-trivial three-dimensional shape and equipped with an adhesive region, where cell-cell binding occurs. By considering both a simple parametric head shape and a computer reconstruction of a real head shape based on morphometric data, we demonstrate that the geometry of the head and the structure of the adhesive region crucially affects both the stability and mobility of the aggregates. Our analysis further suggests that the apical hook commonly found in the sperm of muroid rodents, might serve to shield portions of the adhesive region and promote efficient alignment of the velocities of the interacting cells.

physics.bio-ph↗

arXiv2018

Geometrical control of active turbulence in curved topographies

We investigate the turbulent dynamics of a two-dimensional active nematic liquid crystal con- strained on a curved surface. Using a combination of hydrodynamic and particle-based simulations, we demonstrate that the fundamental structural features of the fluid, such as the topological charge density, the defect number density, the nematic order parameter and defect creation and annihilation rates, are simple linear functions of the substrate Gaussian curvature, which then acts as a control parameter for the chaotic flow. Our theoretical predictions are then compared with experiments on microtubule-kinesin suspensions confined on toroidal active droplets, finding excellent qualitative agreement.

cond-mat.soft↗

arXiv2016

Linear response to leadership, effective temperature and decision making in flocks

Large collections of autonomously moving agents, such as animals or micro-organisms, are able to 'flock' coherently in space even in the absence of a central control mechanism. While the direction of the flock resulting from this critical behavior is random, this can be controlled by a small subset of informed individuals acting as leaders of the group. In this article we use the Vicsek model to investigate how flocks respond to leadership and make decisions. Using a combination of numerical simulations and continuous modeling we demonstrate that flocks display a linear response to leadership that can be cast in the framework of the fluctuation-dissipation theorem, identifying an 'effective temperature' reflecting how promptly the flock reacts to the initiative of the leaders. The linear response to leadership also holds in the presence of two groups of informed individuals with competing interests, indicating that the flock's behavioral decision is determined by both the number of leaders and their degree of influence.

cond-mat.soft↗