Daisy Chen | Searcharxiv

arXiv2026

Explainable AI-based Decision Support for Nocturnal Hypoglycemia Prevention in Type 1 Diabetes

Purpose: Nocturnal hypoglycemia (NH) remains a challenge for individuals with type 1 diabetes (T1D), particularly those who are physically active or on multiple daily injections (MDI). We leveraged an explainable evidential neural network model that forecasts minimum overnight glucose to identify NH risk factors and generate recommendations for NH prevention. Methods: We analyzed the impact of glucose and physical activity (PA) factors on predicted NH probability using SHapley Additive exPlanations (SHAP). Data were from 20 adults with T1D on MDI (10 females; mean age 39 years; HbA1c 7\%) who participated in a cross-over study (NCT05967260). Results: A total of 502 nights were analyzed. Bedtime glucose was the strongest predictor of NH. Other relevant factors included recent exposure to high or low glucose, glucose variability before bedtime, and timing of PA. Some associations appeared physiologically counterintuitive, possibly reflecting behavioral adjustments. Based on the identified risk factors and their SHAP values, we determined key decision points and developed recommendations that may help prevent NH, such as consuming a bedtime snack or discussing potential adjustments to insulin therapy with a healthcare provider. Conclusion: Identifying predictors of NH offers insights for managing NH risk in clinical decision support.

q-bio.QM↗

arXiv2024

Learnable Optimization-Based Algorithms for Low-Dose CT Reconstruction

Low-dose computed tomography (LDCT) aims to minimize the radiation exposure to patients while maintaining diagnostic image quality. However, traditional CT reconstruction algorithms often struggle with the ill-posed nature of the problem, resulting in severe image artifacts. Recent advances in optimization-based deep learning algorithms offer promising solutions to improve LDCT reconstruction. In this paper, we explore learnable optimization algorithms (LOA) for CT reconstruction, which integrate deep learning within variational models to enhance the regularization process. These methods, including LEARN++ and MAGIC, leverage dual-domain networks that optimize both image and sinogram data, significantly improving reconstruction quality. We also present proximal gradient descent and ADMM-inspired networks, which are efficient and theoretically grounded approaches. Our results demonstrate that these learnable methods outperform traditional techniques, offering enhanced artifact reduction, better detail preservation, and robust performance in clinical scenarios.

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