arXiv subjects

Dannong Wang

Publications and source records attributed to Dannong Wang.

4 recordsLinked to original sources

arXiv2026

OncoTriad-QA: A Patient-Level Radiology-Pathology-Genomics Benchmark for Pan-Cancer Reasoning

Cancer diagnosis and characterization require integrating complementary evidence from radiology, pathology, genomics, and clinical metadata. However, most medical large language model (LLM) and vision-language model (VLM) benchmarks focus on isolated modalities or narrow image-text tasks, leaving patient-level oncology assessment across multiple evidence streams largely untested. We introduce OncoTriad-QA, a patient-level radiology-pathology-genomics benchmark for pan-cancer question answering. OncoTriad-QA contains 86.1k semantic questions across 9,281 TCGA patient cases from 32 cancer cohorts, aligning CT/MRI radiology, whole-slide histopathology, somatic mutations, copy-number alterations, DNA methylation, bulk RNA-seq, and clinical metadata. Case-specific annotations are constructed through a source-grounded LLM-assisted pipeline using curated labels, diagnostic reports, molecular profiles, and modality-derived evidence as primary sources of truth, with automated consistency checks and clinician review. We also introduce OncoVLM, a reference multimodal model that maps modality-native radiology, pathology, DNA methylation, and RNA-seq evidence into an LLM interface through learned projectors. Experiments show that existing general-purpose and medical LLMs remain limited on comprehensive pan-cancer QA, especially when questions require integrating imaging findings, tumor morphology, and molecular evidence. After fine-tuning on OncoTriad-QA, OncoVLM exceeds MedGemma-4B by an average of 10.7 points when using MCQ accuracy and BERTScore-F1, with consistent gains across multiple-choice and open-ended questions under radiology-only, pathology-only, and all-available settings. These results demonstrate the benchmark's value for training and evaluating models for integrated cancer question answering.

cs.CL↗

arXiv2026

Quantum-inspired Reinforcement Learning for Synthesizable Drug Design

Synthesizable molecular design (also known as synthesizable molecular optimization) is a fundamental problem in drug discovery, and involves designing novel molecular structures to improve their properties according to drug-relevant oracle functions (i.e., objective) while ensuring synthetic feasibility. However, existing methods are mostly based on random search. To address this issue, in this paper, we introduce a novel approach using the reinforcement learning method with quantum-inspired simulated annealing policy neural network to navigate the vast discrete space of chemical structures intelligently. Specifically, we employ a deterministic REINFORCE algorithm using policy neural networks to output transitional probability to guide state transitions and local search using genetic algorithm to refine solutions to a local optimum within each iteration. Our methods are evaluated with the Practical Molecular Optimization (PMO) benchmark framework with a 10K query budget. We further showcase the competitive performance of our method by comparing it against the state-of-the-art genetic algorithms-based method.

cs.LG↗

arXiv2025

FinLoRA: Benchmarking LoRA Methods for Fine-Tuning LLMs on Financial Datasets

Low-rank adaptation (LoRA) methods show great potential for scaling pre-trained general-purpose Large Language Models (LLMs) to hundreds or thousands of use scenarios. However, their efficacy in high-stakes domains like finance is rarely explored, e.g., passing CFA exams and analyzing SEC filings. In this paper, we present the open-source FinLoRA project that benchmarks LoRA methods on both general and highly professional financial tasks. First, we curated 19 datasets covering diverse financial applications; in particular, we created four novel XBRL analysis datasets based on 150 SEC filings. Second, we evaluated five LoRA methods and five base LLMs. Finally, we provide extensive experimental results in terms of accuracy, F1, and BERTScore and report computational cost in terms of time and GPU memory during fine-tuning and inference stages. We find that LoRA methods achieved substantial performance gains of 36\% on average over base models. Our FinLoRA project provides an affordable and scalable approach to democratize financial intelligence to the general public. Datasets, LoRA adapters, code, and documentation are available at https://github.com/Open-Finance-Lab/FinLoRA

cs.CE↗

arXiv2025

FinLoRA: Finetuning Quantized Financial Large Language Models Using Low-Rank Adaptation

Finetuned large language models (LLMs) have shown remarkable performance in financial tasks, such as sentiment analysis and information retrieval. Due to privacy concerns, finetuning and deploying Financial LLMs (FinLLMs) locally are crucial for institutions. However, finetuning FinLLMs poses challenges including GPU memory constraints and long input sequences. In this paper, we employ quantized low-rank adaptation (QLoRA) to finetune FinLLMs, which leverage low-rank matrix decomposition and quantization techniques to significantly reduce computational requirements while maintaining high model performance. We also employ data and pipeline parallelism to enable local finetuning using cost-effective, widely accessible GPUs. Experiments on financial datasets demonstrate that our method achieves substantial improvements in accuracy, GPU memory usage, and time efficiency, underscoring the potential of lowrank methods for scalable and resource-efficient LLM finetuning.

cs.LG↗