arXiv subjects

Daoqiang Zhang

Publications and source records attributed to Daoqiang Zhang.

At least 73 records · Page 4Linked to original sources

arXiv2021

Improving the Certified Robustness of Neural Networks via Consistency Regularization

A range of defense methods have been proposed to improve the robustness of neural networks on adversarial examples, among which provable defense methods have been demonstrated to be effective to train neural networks that are certifiably robust to the attacker. However, most of these provable defense methods treat all examples equally during training process, which ignore the inconsistent constraint of certified robustness between correctly classified (natural) and misclassified examples. In this paper, we explore this inconsistency caused by misclassified examples and add a novel consistency regularization term to make better use of the misclassified examples. Specifically, we identified that the certified robustness of network can be significantly improved if the constraint of certified robustness on misclassified examples and correctly classified examples is consistent. Motivated by this discovery, we design a new defense regularization term called Misclassification Aware Adversarial Regularization (MAAR), which constrains the output probability distributions of all examples in the certified region of the misclassified example. Experimental results show that our proposed MAAR achieves the best certified robustness and comparable accuracy on CIFAR-10 and MNIST datasets in comparison with several state-of-the-art methods.

cs.LG↗

arXiv2021

Ordinal Pattern Kernel for Brain Connectivity Network Classification

Brain connectivity networks, which characterize the functional or structural interaction of brain regions, has been widely used for brain disease classification. Kernel-based method, such as graph kernel (i.e., kernel defined on graphs), has been proposed for measuring the similarity of brain networks, and yields the promising classification performance. However, most of graph kernels are built on unweighted graph (i.e., network) with edge present or not, and neglecting the valuable weight information of edges in brain connectivity network, with edge weights conveying the strengths of temporal correlation or fiber connection between brain regions. Accordingly, in this paper, we present an ordinal pattern kernel for brain connectivity network classification. Different with existing graph kernels that measures the topological similarity of unweighted graphs, the proposed ordinal pattern kernels calculate the similarity of weighted networks by comparing ordinal patterns from weighted networks. To evaluate the effectiveness of the proposed ordinal kernel, we further develop a depth-first-based ordinal pattern kernel, and perform extensive experiments in a real dataset of brain disease from ADNI database. The results demonstrate that our proposed ordinal pattern kernel can achieve better classification performance compared with state-of-the-art graph kernels.

cs.LG↗

arXiv2020

Transport based Graph Kernels

Graph kernel is a powerful tool measuring the similarity between graphs. Most of the existing graph kernels focused on node labels or attributes and ignored graph hierarchical structure information. In order to effectively utilize graph hierarchical structure information, we propose pyramid graph kernel based on optimal transport (OT). Each graph is embedded into hierarchical structures of the pyramid. Then, the OT distance is utilized to measure the similarity between graphs in hierarchical structures. We also utilize the OT distance to measure the similarity between subgraphs and propose subgraph kernel based on OT. The positive semidefinite (p.s.d) of graph kernels based on optimal transport distance is not necessarily possible. We further propose regularized graph kernel based on OT where we add the kernel regularization to the original optimal transport distance to obtain p.s.d kernel matrix. We evaluate the proposed graph kernels on several benchmark classification tasks and compare their performance with the existing state-of-the-art graph kernels. In most cases, our proposed graph kernel algorithms outperform the competing methods.

cs.LG↗

arXiv2020

Shared Space Transfer Learning for analyzing multi-site fMRI data

Multi-voxel pattern analysis (MVPA) learns predictive models from task-based functional magnetic resonance imaging (fMRI) data, for distinguishing when subjects are performing different cognitive tasks -- e.g., watching movies or making decisions. MVPA works best with a well-designed feature set and an adequate sample size. However, most fMRI datasets are noisy, high-dimensional, expensive to collect, and with small sample sizes. Further, training a robust, generalized predictive model that can analyze homogeneous cognitive tasks provided by multi-site fMRI datasets has additional challenges. This paper proposes the Shared Space Transfer Learning (SSTL) as a novel transfer learning (TL) approach that can functionally align homogeneous multi-site fMRI datasets, and so improve the prediction performance in every site. SSTL first extracts a set of common features for all subjects in each site. It then uses TL to map these site-specific features to a site-independent shared space in order to improve the performance of the MVPA. SSTL uses a scalable optimization procedure that works effectively for high-dimensional fMRI datasets. The optimization procedure extracts the common features for each site by using a single-iteration algorithm and maps these site-specific common features to the site-independent shared space. We evaluate the effectiveness of the proposed method for transferring between various cognitive tasks. Our comprehensive experiments validate that SSTL achieves superior performance to other state-of-the-art analysis techniques.

cs.LG↗

arXiv2020

ASMFS: Adaptive-Similarity-based Multi-modality Feature Selection for Classification of Alzheimer's Disease

With the increasing amounts of high-dimensional heterogeneous data to be processed, multi-modality feature selection has become an important research direction in medical image analysis. Traditional methods usually depict the data structure using fixed and predefined similarity matrix for each modality separately, without considering the potential relationship structure across different modalities. In this paper, we propose a novel multi-modality feature selection method, which performs feature selection and local similarity learning simultaniously. Specially, a similarity matrix is learned by jointly considering different imaging modalities. And at the same time, feature selection is conducted by imposing sparse l_{2, 1} norm constraint. The effectiveness of our proposed joint learning method can be well demonstrated by the experimental results on Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, which outperforms existing the state-of-the-art multi-modality approaches.

cs.CV↗

arXiv2020

Deep Representational Similarity Learning for analyzing neural signatures in task-based fMRI dataset

Similarity analysis is one of the crucial steps in most fMRI studies. Representational Similarity Analysis (RSA) can measure similarities of neural signatures generated by different cognitive states. This paper develops Deep Representational Similarity Learning (DRSL), a deep extension of RSA that is appropriate for analyzing similarities between various cognitive tasks in fMRI datasets with a large number of subjects, and high-dimensionality -- such as whole-brain images. Unlike the previous methods, DRSL is not limited by a linear transformation or a restricted fixed nonlinear kernel function -- such as Gaussian kernel. DRSL utilizes a multi-layer neural network for mapping neural responses to linear space, where this network can implement a customized nonlinear transformation for each subject separately. Furthermore, utilizing a gradient-based optimization in DRSL can significantly reduce runtime of analysis on large datasets because it uses a batch of samples in each iteration rather than all neural responses to find an optimal solution. Empirical studies on multi-subject fMRI datasets with various tasks -- including visual stimuli, decision making, flavor, and working memory -- confirm that the proposed method achieves superior performance to other state-of-the-art RSA algorithms.

eess.IV↗

arXiv2020

A Survey on Deep Learning for Neuroimaging-based Brain Disorder Analysis

Deep learning has been recently used for the analysis of neuroimages, such as structural magnetic resonance imaging (MRI), functional MRI, and positron emission tomography (PET), and has achieved significant performance improvements over traditional machine learning in computer-aided diagnosis of brain disorders. This paper reviews the applications of deep learning methods for neuroimaging-based brain disorder analysis. We first provide a comprehensive overview of deep learning techniques and popular network architectures, by introducing various types of deep neural networks and recent developments. We then review deep learning methods for computer-aided analysis of four typical brain disorders, including Alzheimer's disease, Parkinson's disease, Autism spectrum disorder, and Schizophrenia, where the first two diseases are neurodegenerative disorders and the last two are neurodevelopmental and psychiatric disorders, respectively. More importantly, we discuss the limitations of existing studies and present possible future directions.

eess.IV↗

arXiv2020

Adaptive Feature Selection Guided Deep Forest for COVID-19 Classification with Chest CT

Chest computed tomography (CT) becomes an effective tool to assist the diagnosis of coronavirus disease-19 (COVID-19). Due to the outbreak of COVID-19 worldwide, using the computed-aided diagnosis technique for COVID-19 classification based on CT images could largely alleviate the burden of clinicians. In this paper, we propose an Adaptive Feature Selection guided Deep Forest (AFS-DF) for COVID-19 classification based on chest CT images. Specifically, we first extract location-specific features from CT images. Then, in order to capture the high-level representation of these features with the relatively small-scale data, we leverage a deep forest model to learn high-level representation of the features. Moreover, we propose a feature selection method based on the trained deep forest model to reduce the redundancy of features, where the feature selection could be adaptively incorporated with the COVID-19 classification model. We evaluated our proposed AFS-DF on COVID-19 dataset with 1495 patients of COVID-19 and 1027 patients of community acquired pneumonia (CAP). The accuracy (ACC), sensitivity (SEN), specificity (SPE) and AUC achieved by our method are 91.79%, 93.05%, 89.95% and 96.35%, respectively. Experimental results on the COVID-19 dataset suggest that the proposed AFS-DF achieves superior performance in COVID-19 vs. CAP classification, compared with 4 widely used machine learning methods.

eess.IV↗

arXiv2020

Supervised Hyperalignment for multi-subject fMRI data alignment

Hyperalignment has been widely employed in Multivariate Pattern (MVP) analysis to discover the cognitive states in the human brains based on multi-subject functional Magnetic Resonance Imaging (fMRI) datasets. Most of the existing HA methods utilized unsupervised approaches, where they only maximized the correlation between the voxels with the same position in the time series. However, these unsupervised solutions may not be optimum for handling the functional alignment in the supervised MVP problems. This paper proposes a Supervised Hyperalignment (SHA) method to ensure better functional alignment for MVP analysis, where the proposed method provides a supervised shared space that can maximize the correlation among the stimuli belonging to the same category and minimize the correlation between distinct categories of stimuli. Further, SHA employs a generalized optimization solution, which generates the shared space and calculates the mapped features in a single iteration, hence with optimum time and space complexities for large datasets. Experiments on multi-subject datasets demonstrate that SHA method achieves up to 19% better performance for multi-class problems over the state-of-the-art HA algorithms.

stat.ML↗

arXiv2019

Graph-Based Decoding Model for Functional Alignment of Unaligned fMRI Data

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional topographies of human brains warrant aligning fMRI data across subjects. However, the existing functional alignment methods cannot handle well various kinds of fMRI datasets today, especially when they are not temporally-aligned, i.e., some of the subjects probably lack the responses to some stimuli, or different subjects might follow different sequences of stimuli. In this paper, a cross-subject graph that depicts the (dis)similarities between samples across subjects is used as a priori for developing a more flexible framework that suits an assortment of fMRI datasets. However, the high dimension of fMRI data and the use of multiple subjects makes the crude framework time-consuming or unpractical. To address this issue, we further regularize the framework, so that a novel feasible kernel-based optimization, which permits nonlinear feature extraction, could be theoretically developed. Specifically, a low-dimension assumption is imposed on each new feature space to avoid overfitting caused by the highspatial-low-temporal resolution of fMRI data. Experimental results on five datasets suggest that the proposed method is not only superior to several state-of-the-art methods on temporally-aligned fMRI data, but also suitable for dealing `with temporally-unaligned fMRI data.

cs.LG↗

arXiv2019

SEGAN: Structure-Enhanced Generative Adversarial Network for Compressed Sensing MRI Reconstruction

Generative Adversarial Networks (GANs) are powerful tools for reconstructing Compressed Sensing Magnetic Resonance Imaging (CS-MRI). However most recent works lack exploration of structure information of MRI images that is crucial for clinical diagnosis. To tackle this problem, we propose the Structure-Enhanced GAN (SEGAN) that aims at restoring structure information at both local and global scale. SEGAN defines a new structure regularization called Patch Correlation Regularization (PCR) which allows for efficient extraction of structure information. In addition, to further enhance the ability to uncover structure information, we propose a novel generator SU-Net by incorporating multiple-scale convolution filters into each layer. Besides, we theoretically analyze the convergence of stochastic factors contained in training process. Experimental results show that SEGAN is able to learn target structure information and achieves state-of-the-art performance for CS-MRI reconstruction.

cs.CV↗

arXiv2018

Gradient-based Representational Similarity Analysis with Searchlight for Analyzing fMRI Data

Representational Similarity Analysis (RSA) aims to explore similarities between neural activities of different stimuli. Classical RSA techniques employ the inverse of the covariance matrix to explore a linear model between the neural activities and task events. However, calculating the inverse of a large-scale covariance matrix is time-consuming and can reduce the stability and robustness of the final analysis. Notably, it becomes severe when the number of samples is too large. For facing this shortcoming, this paper proposes a novel RSA method called gradient-based RSA (GRSA). Moreover, the proposed method is not restricted to a linear model. In fact, there is a growing interest in finding more effective ways of using multi-subject and whole-brain fMRI data. Searchlight technique can extend RSA from the localized brain regions to the whole-brain regions with smaller memory footprint in each process. Based on Searchlight, we propose a new method called Spatiotemporal Searchlight GRSA (SSL-GRSA) that generalizes our ROI-based GRSA algorithm to the whole-brain data. Further, our approach can handle some computational challenges while dealing with large-scale, multi-subject fMRI data. Experimental studies on multi-subject datasets confirm that both proposed approaches achieve superior performance to other state-of-the-art RSA algorithms.

q-bio.NC↗

arXiv2018

Multi-Objective Cognitive Model: a supervised approach for multi-subject fMRI analysis

In order to decode the human brain, Multivariate Pattern (MVP) classification generates cognitive models by using functional Magnetic Resonance Imaging (fMRI) datasets. As a standard pipeline in the MVP analysis, brain patterns in multi-subject fMRI dataset must be mapped to a shared space and then a classification model is generated by employing the mapped patterns. However, the MVP models may not provide stable performance on a new fMRI dataset because the standard pipeline uses disjoint steps for generating these models. Indeed, each step in the pipeline includes an objective function with independent optimization approach, where the best solution of each step may not be optimum for the next steps. For tackling the mentioned issue, this paper introduces the Multi-Objective Cognitive Model (MOCM) that utilizes an integrated objective function for MVP analysis rather than just using those disjoint steps. For solving the integrated problem, we proposed a customized multi-objective optimization approach, where all possible solutions are firstly generated, and then our method ranks and selects the robust solutions as the final results. Empirical studies confirm that the proposed method can generate superior performance in comparison with other techniques.

stat.ML↗

arXiv2018

Gradient Hyperalignment for multi-subject fMRI data alignment

Multi-subject fMRI data analysis is an interesting and challenging problem in human brain decoding studies. The inherent anatomical and functional variability across subjects make it necessary to do both anatomical and functional alignment before classification analysis. Besides, when it comes to big data, time complexity becomes a problem that cannot be ignored. This paper proposes Gradient Hyperalignment (Gradient-HA) as a gradient-based functional alignment method that is suitable for multi-subject fMRI datasets with large amounts of samples and voxels. The advantage of Gradient-HA is that it can solve independence and high dimension problems by using Independent Component Analysis (ICA) and Stochastic Gradient Ascent (SGA). Validation using multi-classification tasks on big data demonstrates that Gradient-HA method has less time complexity and better or comparable performance compared with other state-of-the-art functional alignment methods.

cs.LG↗

arXiv2017

Deep Hyperalignment

This paper proposes Deep Hyperalignment (DHA) as a regularized, deep extension, scalable Hyperalignment (HA) method, which is well-suited for applying functional alignment to fMRI datasets with nonlinearity, high-dimensionality (broad ROI), and a large number of subjects. Unlink previous methods, DHA is not limited by a restricted fixed kernel function. Further, it uses a parametric approach, rank-$m$ Singular Value Decomposition (SVD), and stochastic gradient descent for optimization. Therefore, DHA has a suitable time complexity for large datasets, and DHA does not require the training data when it computes the functional alignment for a new subject. Experimental studies on multi-subject fMRI analysis confirm that the DHA method achieves superior performance to other state-of-the-art HA algorithms.

q-bio.NC↗

arXiv2017

Anatomical Pattern Analysis for decoding visual stimuli in human brains

Background: A universal unanswered question in neuroscience and machine learning is whether computers can decode the patterns of the human brain. Multi-Voxels Pattern Analysis (MVPA) is a critical tool for addressing this question. However, there are two challenges in the previous MVPA methods, which include decreasing sparsity and noise in the extracted features and increasing the performance of prediction. Methods: In overcoming mentioned challenges, this paper proposes Anatomical Pattern Analysis (APA) for decoding visual stimuli in the human brain. This framework develops a novel anatomical feature extraction method and a new imbalance AdaBoost algorithm for binary classification. Further, it utilizes an Error-Correcting Output Codes (ECOC) method for multiclass prediction. APA can automatically detect active regions for each category of the visual stimuli. Moreover, it enables us to combine homogeneous datasets for applying advanced classification. Results and Conclusions: Experimental studies on 4 visual categories (words, consonants, objects and scrambled photos) demonstrate that the proposed approach achieves superior performance to state-of-the-art methods.

stat.ML↗

arXiv2016

Multi-Region Neural Representation: A novel model for decoding visual stimuli in human brains

Multivariate Pattern (MVP) classification holds enormous potential for decoding visual stimuli in the human brain by employing task-based fMRI data sets. There is a wide range of challenges in the MVP techniques, i.e. decreasing noise and sparsity, defining effective regions of interest (ROIs), visualizing results, and the cost of brain studies. In overcoming these challenges, this paper proposes a novel model of neural representation, which can automatically detect the active regions for each visual stimulus and then utilize these anatomical regions for visualizing and analyzing the functional activities. Therefore, this model provides an opportunity for neuroscientists to ask this question: what is the effect of a stimulus on each of the detected regions instead of just study the fluctuation of voxels in the manually selected ROIs. Moreover, our method introduces analyzing snapshots of brain image for decreasing sparsity rather than using the whole of fMRI time series. Further, a new Gaussian smoothing method is proposed for removing noise of voxels in the level of ROIs. The proposed method enables us to combine different fMRI data sets for reducing the cost of brain studies. Experimental studies on 4 visual categories (words, consonants, objects and nonsense photos) confirm that the proposed method achieves superior performance to state-of-the-art methods.

stat.ML↗

arXiv2016

WoCE: a framework for clustering ensemble by exploiting the wisdom of Crowds theory

The Wisdom of Crowds (WOC), as a theory in the social science, gets a new paradigm in computer science. The WOC theory explains that the aggregate decision made by a group is often better than those of its individual members if specific conditions are satisfied. This paper presents a novel framework for unsupervised and semi-supervised cluster ensemble by exploiting the WOC theory. We employ four conditions in the WOC theory, i.e., diversity, independency, decentralization and aggregation, to guide both the constructing of individual clustering results and the final combination for clustering ensemble. Firstly, independency criterion, as a novel mapping system on the raw data set, removes the correlation between features on our proposed method. Then, decentralization as a novel mechanism generates high-quality individual clustering results. Next, uniformity as a new diversity metric evaluates the generated clustering results. Further, weighted evidence accumulation clustering method is proposed for the final aggregation without using thresholding procedure. Experimental study on varied data sets demonstrates that the proposed approach achieves superior performance to state-of-the-art methods.

stat.ML↗