arXiv subjects

Dario Farina

Publications and source records attributed to Dario Farina.

33 records · Page 2Linked to original sources

arXiv2024

Separation of Neural Drives to Muscles from Transferred Polyfunctional Nerves using Implanted Micro-electrode Arrays

Following limb amputation, neural signals for limb functions persist in the residual peripheral nerves. Targeted muscle reinnervation (TMR) allows to redirected these signals into spare muscles to recover the neural information through electromyography (EMG). However, a significant challenge arises in separating distinct neural commands redirected from the transferred nerves to the muscles. Disentangling overlapping signals from EMG recordings remains complex, as they can contain mixed neural information that complicates limb function interpretation. To address this challenge, Regenerative Peripheral Nerve Interfaces (RPNIs) surgically partition the nerve into individual fascicles that reinnervate specific muscle grafts, isolating distinct neural sources for more precise control and interpretation of EMG signals. We introduce a novel biointerface that combines TMR surgery of polyvalent nerves with a high-density micro-electrode array implanted at a single site within a reinnervated muscle. Instead of surgically identifying distinct nerve fascicles, our approach separates all neural signals that are re-directed into a single muscle, using the high spatio-temporal selectivity of the micro-electrode array and mathematical source separation methods. We recorded EMG signals from four reinnervated muscles while volunteers performed phantom limb tasks. The decomposition of these signals into motor unit activity revealed distinct clusters of motor neurons associated with diverse functional tasks. Notably, our method enabled the extraction of multiple neural commands within a single reinnervated muscle, eliminating the need for surgical nerve division. This approach not only has the potential of enhancing prosthesis control but also uncovers mechanisms of motor neuron synergies following TMR, providing valuable insights into how the central nervous system encodes movement after reinnervation.

q-bio.NC↗

arXiv2024

Alterations of electrocortical activity during hand movements induced by motor cortex glioma

Glioma cells can reshape functional neuronal networks by hijacking neuronal synapses, leading to partial or complete neurological dysfunction. These mechanisms have been previously explored for language functions. However, the impact of glioma on sensorimotor functions is still unknown. Therefore, we recruited a control group of patients with unaffected motor cortex and a group of patients with glioma-infiltrated motor cortex, and recorded high-density electrocortical signals during finger movement tasks. The results showed that glioma suppresses task-related synchronization in the high-gamma band and reduces the power across all frequency bands. The resulting atypical motor information transmission model with discrete signaling pathways and delayed responses disrupts the stability of neuronal encoding patterns for finger movement kinematics across various temporal-spatial scales. These findings demonstrate that gliomas functionally invade neural circuits within the motor cortex. This result advances our understanding of motor function processing in chronic disease states, which is important to advance the surgical strategies and neurorehabilitation approaches for patients with malignant gliomas.

q-bio.NC↗

arXiv2024

Design, Fabrication and Evaluation of a Stretchable High-Density Electromyography Array

The adoption of high-density electrode systems for human-machine interfaces in real-life applications has been impeded by practical and technical challenges, including noise interference, motion artifacts and the lack of compact electrode interfaces. To overcome some of these challenges, we introduce a wearable and stretchable electromyography (EMG) array, and present its design, fabrication methodology, characterisation, and comprehensive evaluation. Our proposed solution comprises dry-electrodes on flexible printed circuit board (PCB) substrates, eliminating the need for time-consuming skin preparation. The proposed fabrication method allows the manufacturing of stretchable sleeves, with consistent and standardised coverage across subjects. We thoroughly tested our developed prototype, evaluating its potential for application in both research and real-world environments. The results of our study showed that the developed stretchable array matches or outperforms traditional EMG grids and holds promise in furthering the real-world translation of high-density EMG for human-machine interfaces.

cs.RO↗

arXiv2024

Tackling Electrode Shift In Gesture Recognition with HD-EMG Electrode Subsets

sEMG pattern recognition algorithms have been explored extensively in decoding movement intent, yet are known to be vulnerable to changing recording conditions, exhibiting significant drops in performance across subjects, and even across sessions. Multi-channel surface EMG, also referred to as high-density sEMG (HD-sEMG) systems, have been used to improve performance with the information collected through the use of additional electrodes. However, a lack of robustness is ever present due to limited datasets and the difficulties in addressing sources of variability, such as electrode placement. In this study, we propose training on a collection of input channel subsets and augmenting our training distribution with data from different electrode locations, simultaneously targeting electrode shift and reducing input dimensionality. Our method increases robustness against electrode shift and results in significantly higher intersession performance across subjects and classification algorithms.

cs.LG↗

arXiv2023

Conditional Generative Models for Simulation of EMG During Naturalistic Movements

Numerical models of electromyographic (EMG) signals have provided a huge contribution to our fundamental understanding of human neurophysiology and remain a central pillar of motor neuroscience and the development of human-machine interfaces. However, whilst modern biophysical simulations based on finite element methods are highly accurate, they are extremely computationally expensive and thus are generally limited to modelling static systems such as isometrically contracting limbs. As a solution to this problem, we propose a transfer learning approach, in which a conditional generative model is trained to mimic the output of an advanced numerical model. To this end, we present BioMime, a conditional generative neural network trained adversarially to generate motor unit activation potential waveforms under a wide variety of volume conductor parameters. We demonstrate the ability of such a model to predictively interpolate between a much smaller number of numerical model's outputs with a high accuracy. Consequently, the computational load is dramatically reduced, which allows the rapid simulation of EMG signals during truly dynamic and naturalistic movements.

cs.LG↗

arXiv2023

A Human-Machine Joint Learning Framework to Boost Endogenous BCI Training

Brain-computer interfaces (BCIs) provide a direct pathway from the brain to external devices and have demonstrated great potential for assistive and rehabilitation technologies. Endogenous BCIs based on electroencephalogram (EEG) signals, such as motor imagery (MI) BCIs, can provide some level of control. However, mastering spontaneous BCI control requires the users to generate discriminative and stable brain signal patterns by imagery, which is challenging and is usually achieved over a very long training time (weeks/months). Here, we propose a human-machine joint learning framework to boost the learning process in endogenous BCIs, by guiding the user to generate brain signals towards an optimal distribution estimated by the decoder, given the historical brain signals of the user. To this end, we firstly model the human-machine joint learning process in a uniform formulation. Then a human-machine joint learning framework is proposed: 1) for the human side, we model the learning process in a sequential trial-and-error scenario and propose a novel ``copy/new'' feedback paradigm to help shape the signal generation of the subject toward the optimal distribution; 2) for the machine side, we propose a novel adaptive learning algorithm to learn an optimal signal distribution along with the subject's learning process. Specifically, the decoder reweighs the brain signals generated by the subject to focus more on ``good'' samples to cope with the learning process of the subject. Online and psuedo-online BCI experiments with 18 healthy subjects demonstrated the advantages of the proposed joint learning process over co-adaptive approaches in both learning efficiency and effectiveness.

cs.HC↗

arXiv2022

Toward a Framework for Adaptive Impedance Control of an Upper-limb Prosthesis

Adapting upper-limb impedance (i.e., stiffness, damping, inertia) is essential for humans interacting with dynamic environments for executing grasping or manipulation tasks. On the other hand, control methods designed for state-of-the-art upper-limb prostheses infer motor intent from surface electromyography (sEMG) signals in terms of joint kinematics, but they fail to infer and use the underlying impedance properties of the limb. We present a framework that allows a human user to simultaneously control the kinematics, stiffness, and damping of a simulated robot through wrist's flexion-extension. The framework includes muscle-tendon units and a forward dynamics block to estimate the motor intent from sEMG signals, and a variable impedance controller that implements the estimated intent on the robot, allowing the user to adapt the robot's kinematics and dynamics online. We evaluate our framework with 8 able-bodied subjects and an amputee during reaching tasks performed in free space, and in the presence of unexpected external perturbations that require adaptation of the wrist impedance to ensure stable interaction with the environment. We experimentally demonstrate that our approach outperforms a data-driven baseline in terms of its ability to adapt to external perturbations, overall controllability, and feedback from participants.

cs.RO↗

arXiv2022

Common Synaptic Input, Synergies, and Size Principle: Control of Spinal Motor Neurons for Movement Generation

Understanding how movement is controlled by the central nervous system remains a major challenge, with ongoing debate about basic features underlying this control. In this review, we introduce a new conceptual framework for the distribution of common input to spinal motor neurons. Specifically, this framework is based on the following assumptions: 1) motor neurons are grouped into functional groups (clusters) based on the common inputs they receive; 2) clusters may significantly differ from the classical definition of motor neuron pools, such that they may span across muscles and/or involve only a portion of a muscle; 3) clusters represent functional modules used by the central nervous system to reduce the dimensionality of the control; and 4) selective volitional control of single motor neurons within a cluster receiving common inputs cannot be achieved. We discuss this framework and its underlying theoretical and experimental evidence.

q-bio.NC↗

arXiv2021

Hand Gesture Recognition Using Temporal Convolutions and Attention Mechanism

Advances in biosignal signal processing and machine learning, in particular Deep Neural Networks (DNNs), have paved the way for the development of innovative Human-Machine Interfaces for decoding the human intent and controlling artificial limbs. DNN models have shown promising results with respect to other algorithms for decoding muscle electrical activity, especially for recognition of hand gestures. Such data-driven models, however, have been challenged by their need for a large number of trainable parameters and their structural complexity. Here we propose the novel Temporal Convolutions-based Hand Gesture Recognition architecture (TC-HGR) to reduce this computational burden. With this approach, we classified 17 hand gestures via surface Electromyogram (sEMG) signals by the adoption of attention mechanisms and temporal convolutions. The proposed method led to 81.65% and 80.72% classification accuracy for window sizes of 300ms and 200ms, respectively. The number of parameters to train the proposed TC-HGR architecture is 11.9 times less than that of its state-of-the-art counterpart.

cs.LG↗

arXiv2021

Deep Metric Learning with Locality Sensitive Angular Loss for Self-Correcting Source Separation of Neural Spiking Signals

Neurophysiological time series, such as electromyographic signal and intracortical recordings, are typically composed of many individual spiking sources, the recovery of which can give fundamental insights into the biological system of interest or provide neural information for man-machine interfaces. For this reason, source separation algorithms have become an increasingly important tool in neuroscience and neuroengineering. However, in noisy or highly multivariate recordings these decomposition techniques often make a large number of errors, which degrades human-machine interfacing applications and often requires costly post-hoc manual cleaning of the output label set of spike timestamps. To address both the need for automated post-hoc cleaning and robust separation filters we propose a methodology based on deep metric learning, using a novel loss function which maintains intra-class variance, creating a rich embedding space suitable for both label cleaning and the discovery of new activations. We then validate this method with an artificially corrupted label set based on source-separated high-density surface electromyography recordings, recovering the original timestamps even in extreme degrees of feature and class-dependent label noise. This approach enables a neural network to learn to accurately decode neurophysiological time series using any imperfect method of labelling the signal.

cs.LG↗

arXiv2021

TEMGNet: Deep Transformer-based Decoding of Upperlimb sEMG for Hand Gestures Recognition

There has been a surge of recent interest in Machine Learning (ML), particularly Deep Neural Network (DNN)-based models, to decode muscle activities from surface Electromyography (sEMG) signals for myoelectric control of neurorobotic systems. DNN-based models, however, require large training sets and, typically, have high structural complexity, i.e., they depend on a large number of trainable parameters. To address these issues, we developed a framework based on the Transformer architecture for processing sEMG signals. We propose a novel Vision Transformer (ViT)-based neural network architecture (referred to as the TEMGNet) to classify and recognize upperlimb hand gestures from sEMG to be used for myocontrol of prostheses. The proposed TEMGNet architecture is trained with a small dataset without the need for pre-training or fine-tuning. To evaluate the efficacy, following the-recent literature, the second subset (exercise B) of the NinaPro DB2 dataset was utilized, where the proposed TEMGNet framework achieved a recognition accuracy of 82.93% and 82.05% for window sizes of 300ms and 200ms, respectively, outperforming its state-of-the-art counterparts. Moreover, the proposed TEMGNet framework is superior in terms of structural capacity while having seven times fewer trainable parameters. These characteristics and the high performance make DNN-based models promising approaches for myoelectric control of neurorobots.

cs.LG↗

arXiv2021

Human movement augmentation and how to make it a reality

Augmenting the body with artificial limbs controlled concurrently to the natural limbs has long appeared in science fiction, but recent technological and neuroscientific advances have begun to make this vision possible. By allowing individuals to achieve otherwise impossible actions, this movement augmentation could revolutionize medical and industrial applications and profoundly change the way humans interact with their environment. Here, we construct a movement augmentation taxonomy through what is augmented and how it is achieved. With this framework, we analyze augmentation that extends the number of degrees-of-freedom, discuss critical features of effective augmentation such as physiological control signals, sensory feedback and learning, and propose a vision for the field.

cs.RO↗

arXiv2021

Modelling and Analysis of Magnetic Fields from Skeletal Muscle for Valuable Physiological Measurements

MagnetoMyoGraphy (MMG) is a method of studying muscle function via weak magnetic fields generated from human active organs and tissues. The correspondence between MMG and electromyography means directly derived from the Maxwell-Ampère law. Here, upon briefly describing the principles of voltage distribution inside skeletal muscles due to the electrical stimulation, we provide a protocol to determine the effects of the magnetic field generated from a time-changing action potential propagating in a group of skeletal muscle cells. The position-dependent and the magnetic field behaviour on account of the different currents in muscle fibres are performed in temporal, spectral and spatial domains. The procedure covers identification of the fibre subpopulations inside the fascicles of a given nerve section, characterization of soleus skeletal muscle currents, check of axial intracellular currents, calculation of the generated magnetic field ultimately. We expect this protocol to take approximately 2-3 hours to complete for the whole finite-element analysis.

eess.SY↗

arXiv2020

FS-HGR: Few-shot Learning for Hand Gesture Recognition via ElectroMyography

This work is motivated by the recent advances in Deep Neural Networks (DNNs) and their widespread applications in human-machine interfaces. DNNs have been recently used for detecting the intended hand gesture through processing of surface electromyogram (sEMG) signals. The ultimate goal of these approaches is to realize high-performance controllers for prosthetic. However, although DNNs have shown superior accuracy than conventional methods when large amounts of data are available for training, their performance substantially decreases when data are limited. Collecting large datasets for training may be feasible in research laboratories, but it is not a practical approach for real-life applications. Therefore, there is an unmet need for the design of a modern gesture detection technique that relies on minimal training data while providing high accuracy. Here we propose an innovative and novel "Few-Shot Learning" framework based on the formulation of meta-learning, referred to as the FS-HGR, to address this need. Few-shot learning is a variant of domain adaptation with the goal of inferring the required output based on just one or a few training examples. More specifically, the proposed FS-HGR quickly generalizes after seeing very few examples from each class. The proposed approach led to 85.94% classification accuracy on new repetitions with few-shot observation (5-way 5-shot), 81.29% accuracy on new subjects with few-shot observation (5-way 5-shot), and 73.36% accuracy on new gestures with few-shot observation (5-way 5-shot).

cs.LG↗

arXiv2019

Unsupervised decoding of spinal motor neuron spike trains for estimating hand kinematics following targeted muscle reinnervation

The performance of upper-limb prostheses is currently limited by the relatively poor functionality of unintuitive control schemes. This paper proposes to extract, from multichannel electromyographic signals (EMG), motor neuron spike trains and project them into lower dimensional continuous signals, which are used as multichannel proportional inputs to control the prosthetic's actuators. These control signals are an estimation of the common synaptic input that the motor neurons receive. We use the simplest of metric learning approaches known as principal component analysis (PCA), as a linear unsupervised metric projection to extract the spectral information of high dimensional data into the subspace of the prosthetic hand degrees of freedom. We also investigate the importance of a rotation in the projection space that best aligns the PCA subspace with the space of degrees of freedom of the prosthetic hand, to attempt to approximate the sparseness properties of the motor axes (which are orthogonal), while no sparseness is enforced by PCA. Proof of concept for the feedforward path (open loop) is given by successful estimation of concurrent movements with up to three degrees of freedom. We also analyze and quantify the performance of the proposed decoding algorithm under implementation constraints and hardware limitations and propose a space-time subsampling strategy, to maximize projection fidelity, in each extracted source over time. The results confirm that the proposed decoding approach can directly project the motor neuron spike trains into kinematics for simultaneous and proportional prosthesis control that can be extended to multiple degrees of freedom. We show that the method is robust to reducing the training data in space (number of sources) and time, which makes it potentially suitable for clinical applications.

eess.SP↗