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David A Kessler

Publications and source records attributed to David A Kessler.

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Sokoban Random Walk: A Trapping Perspective

We study caging/trapping in Sokoban-type models, featuring a random walker moving through a disordered medium of obstacles and capable of pushing some obstacles blocking its path. In one-dimension, we allow the walker to push up to an arbitrary $N_{\rm P}$ number of obstacles. For $N_{\rm P}\gg 1$, we use large-deviation theory to show that the survival probability to remain uncaged exhibits crossover from an exponential decay with time at intermediate times to a stretched-exponential decay at long times, with an exponent $1/3$ independent of $N_{\rm P}$. The long-time exponent matches the Balagurov--Vaks--Donsker--Varadhan (BVDV) theory of the classical trapping problem, while the exponential decay is qualitatively distinct from the Rosenstock's intermediate-time theory for classical trapping. Similarly, in two dimensions, numerical simulations reveal that both the Sokoban model and its generalized version exhibit long-time stretched-exponential relaxation with exponent $1/2$, again consistent with the BVDV theory. Finally, in two dimensions, we find that the mean trap size is nonmonotonic in $\rho$: it is small at both low and high densities, but reaches a peak at a characteristic density $\rho_*$. We estimate $\rho_* \approx 0.55$ for the Sokoban model and $\rho_* \approx 0.675$ for the generalized Sokoban model.

cond-mat.stat-mech

Darwinian Selection Induces Lamarckian Adaptation in a Holobiont Model

Current models of animal evolution focus on selection of individuals, ignoring the much faster selection of symbiotic bacteria. Here we take host-symbiont interactions into account by introducing a Population Genetics-like model of holobionts exposed to toxic stress. The stress can be alleviated by selection of resistant individuals (host and bacteria) and by secretion of a detoxification agent ("detox"). By defining a new measure, termed the Lamarckian, we show that selection of resistant bacteria over one generation of hosts leads to stress-dependent increase in the tolerance of the host's offspring. This benefit is mediated by co-alleviation of toxic and physiologic stress. Prolonged exposure leads to further adaptation by 'group selection' of bacterial communities with higher detox per bacterium. These findings show that Lamarckian adaptation can arise via interactions between two levels of Darwinian selection within a holobiont system. The conclusions and modelling framework are applicable to diverse types of holobiont systems.

q-bio.PE