David Aguilar | Searcharxiv

arXiv2026

The Twentieth Data Release of the Sloan Digital Sky Survey: First All-Sky BOSS Spectra, eROSITA-SDSS-V Mapper Coordinated Observations, and a Preview of the Local Volume Mapper

This paper presents the twentieth data release (DR20) from the Sloan Digital Sky Survey, the third data release of its fifth generation (SDSS-V). SDSS-V is a panoptic spectroscopy survey that is mapping the stars, gas, and galaxies through three scientific programs: the Milky Way Mapper (MWM), the Local Volume Mapper (LVM), and the Black Hole Mapper (BHM). DR20 presents the first optical (BOSS) SDSS-V spectra from southern hemisphere for the MWM and BHM surveys; new optical MWM and BHM data from the northern hemisphere are also available, for a total over 3 million spectra of 1.5 million stars and half a million galaxies and quasars, with galactic and extragalactic x-ray targets coordinate with eROSITA DR2. DR20 includes integral field spectroscopy maps from LVM of six targets and 169 tiles, spanning Galactic HII regions, planetary nebulae, and nearby galaxies. Additionally, eighteen value added catalogs are also released with DR20, based on SDSS-V MWM and BHM data, and we present a new LVM visualization tool including an RGB HiPS map as a value added product.

astro-ph.GA↗

arXiv2018

A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function

Heart failure is a major cause for premature death. Given heterogeneity of the heart failure syndrome, identifying genetic determinants of cardiac function and structure may provide greater insights into heart failure. Despite progress in understanding the genetic basis of heart failure through genome wide association studies, heritability of heart failure is not well understood. Gaining further insights into mechanisms that contribute to heart failure requires systematic approaches that go beyond single trait analysis. We integrated Bayesian multi-trait approach and Bayesian networks for the analysis of 10 correlated traits of cardiac structure and function measured for 3387 individuals with whole exome sequence data. While using single-trait based approaches did not find any significant genetic variant, applying the integrative Bayesian multi-trait approach, we identified 3 novel variants located in genes, RGS3, CHD3, and MRPL38 with significant impact on the cardiac traits such as left ventricular volume index, parasternal long axis interventricular septum thickness, and mean left ventricular wall thickness. Among these, the rare variant NC_000009.11:g.116346115C>A (rs144636307) in RGS3 showed pleiotropic effect on left ventricular mass index, left ventricular volume index and Maximum left atrial anterior-posterior diameter while RGS3 can inhibit TGF-beta signaling associated with left ventricle dilation and systolic dysfunction.

q-bio.GN↗