arXiv subjects

David B. Camarillo

Publications and source records attributed to David B. Camarillo.

22 records · Page 2Linked to original sources

arXiv2019

Autonomous Driving in the Lung using Deep Learning for Localization

Lung cancer is the leading cause of cancer-related death worldwide, and early diagnosis is critical to improving patient outcomes. To diagnose cancer, a highly trained pulmonologist must navigate a flexible bronchoscope deep into the branched structure of the lung for biopsy. The biopsy fails to sample the target tissue in 26-33% of cases largely because of poor registration with the preoperative CT map. To improve intraoperative registration, we develop two deep learning approaches to localize the bronchoscope in the preoperative CT map based on the bronchoscopic video in real-time, called AirwayNet and BifurcationNet. The networks are trained entirely on simulated images derived from the patient-specific CT. When evaluated on recorded bronchoscopy videos in a phantom lung, AirwayNet outperforms other deep learning localization algorithms with an area under the precision-recall curve of 0.97. Using AirwayNet, we demonstrate autonomous driving in the phantom lung based on video feedback alone. The robot reaches four targets in the left and right lungs in 95% of the trials. On recorded videos in eight human cadaver lungs, AirwayNet achieves areas under the precision-recall curve ranging from 0.82 to 0.997.

cs.CV↗

arXiv2019

Multi-directional dynamic model for traumatic brain injury detection

Traumatic brain injury (TBI) is a complex injury that is hard to predict and diagnose, with many studies focused on associating head kinematics to brain injury risk. Recently, there has been a push towards using computationally expensive finite element (FE) models of the brain to create tissue deformation metrics of brain injury. Here, we developed a 3 degree-of-freedom lumped-parameter brain model, built based on the measured natural frequencies of a FE brain model simulated with live human impact data, to be used to rapidly estimate peak brain strains experienced during head rotational accelerations. On our dataset, the simplified model correlates with peak principal FE strain by an R2 of 0.80. Further, coronal and axial model displacement correlated with fiber-oriented peak strain in the corpus callosum with an R2 of 0.77. Using the maximum displacement predicted by our brain model, we propose an injury criteria and compare it against a number of existing rotational and translational kinematic injury metrics on a dataset of head kinematics from 27 clinically diagnosed injuries and 887 non-injuries. We found that our proposed metric performed comparably to peak angular acceleration, linear acceleration, and angular velocity in classifying injury and non-injury events. Metrics which separated time traces into their directional components had improved deviance to those which combined components into a single time trace magnitude. Our brain model can be used in future work as a computationally efficient alternative to FE models for classifying injuries over a wide range of loading conditions.

q-bio.QM↗

arXiv2019

Deep Learning for Localization in the Lung

Lung cancer is the leading cause of cancer-related death worldwide, and early diagnosis is critical to improving patient outcomes. To diagnose cancer, a highly trained pulmonologist must navigate a flexible bronchoscope deep into the branched structure of the lung for biopsy. The biopsy fails to sample the target tissue in 26-33% of cases largely because of poor registration with the preoperative CT map. We developed two deep learning approaches to localize the bronchoscope in the preoperative CT map in real time and tested the algorithms across 13 trajectories in a lung phantom and 68 trajectories in 11 human cadaver lungs. In the lung phantom, we observe performance reaching 95% precision and recall of visible airways and 3 mm average position error. On a successful cadaver lung sequence, the algorithms trained on simulation alone achieved 77%-94% precision and recall of visible airways and 4-6 mm average position error. We also compare the effect of GAN-stylizing images and we look at aggregate statistics over the entire set of trajectories.

cs.CV↗

arXiv2015

In vivo evaluation of wearable head impact sensors

Inertial sensors are commonly used to measure human head motion. Some sensors have been validated with dummy or cadaver experiments, but methods to evaluate sensors in vivo are lacking. Here we present an in vivo method using high speed video to evaluate teeth-mounted (mouthguard), soft tissue-mounted (skin patch), and headgear-mounted (skull cap) sensors during 6-13g sagittal soccer head impacts. Sensor coupling to the skull is quantified by displacement from an ear-canal reference. Mouthguard displacements were within video measurement error (<1mm), while the skin patch and skull cap displaced up to 4mm and 13mm from the ear-canal reference, respectively. We used the mouthguard, which had the least displacement from skull, as the reference to assess 6-degree-of-freedom skin patch and skull cap measurements. Linear and rotational acceleration magnitudes were over-predicted by both the skin patch (with 120% NRMS error for a_mag, 290% for alpha_mag) and the skull cap (320% NRMS error for a_mag, 500% for alpha_mag). Such over-predictions were largely due to out-of-plane motion. To model sensor error, we found that in-plane acceleration peaks from the skin patch in the anterior-posterior direction could be modeled by an underdamped viscoelastic system. In summary, the mouthguard showed tighter skull coupling in vivo than the other sensors. Furthermore, the in vivo methods presented are valuable for investigating skull acceleration sensor technologies.

q-bio.QM↗