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David Brundage

Publications and source records attributed to David Brundage.

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Generating Synthetic Wildlife Health Data from Camera Trap Imagery: A Pipeline for Alopecia and Body Condition Training Data

No publicly available, ML ready datasets exist for wildlife health conditions in camera trap imagery, creating a fundamental barrier to automated health screening. We present a pipeline for generating synthetic training images depicting alopecia and body condition deterioration in wildlife from real camera trap photographs. Our pipeline constructs a curated base image set from iWildCam using MegaDetector derived bounding boxes and center frame weighted stratified sampling across 8 North American species. A generative phenotype editing system produces controlled severity variants depicting hair loss consistent with mange and emaciation. An adaptive scene drift quality control system uses a sham prefilter and decoupled mask then score approach with complementary day or night metrics to reject images where the generative model altered the original scene. We frame the pipeline explicitly as a screening data source. From 201 base images across 4 species, we generate 553 QC passing synthetic variants with an overall pass rate of 83 percent. A sim to real transfer experiment training exclusively on synthetic data and testing on real camera trap images of suspected health conditions achieves 0.85 AUROC, demonstrating that the synthetic data captures visual features sufficient for screening.

cs.CV

Synthetic Data for Veterinary EHR De-identification: Benefits, Limits, and Safety Trade-offs Under Fixed Compute

Veterinary electronic health records (vEHRs) contain privacy-sensitive identifiers that limit secondary use. While PetEVAL provides a benchmark for veterinary de-identification, the domain remains low-resource. This study evaluates whether large language model (LLM)-generated synthetic narratives improve de-identification safety under distinct training regimes, emphasizing (i) synthetic augmentation and (ii) fixed-budget substitution. We conducted a controlled simulation using a PetEVAL-derived corpus (3,750 holdout/1,249 train). We generated 10,382 synthetic notes using a privacy-preserving "template-only" regime where identifiers were removed prior to LLM prompting. Three transformer backbones (PetBERT, VetBERT, Bio_ClinicalBERT) were trained under varying mixtures. Evaluation prioritized document-level leakage rate (the fraction of documents with at least one missed identifier) as the primary safety outcome. Results show that under fixed-sample substitution, replacing real notes with synthetic ones monotonically increased leakage, indicating synthetic data cannot safely replace real supervision. Under compute-matched training, moderate synthetic mixing matched real-only performance, but high synthetic dominance degraded utility. Conversely, epoch-scaled augmentation improved performance: PetBERT span-overlap F1 increased from 0.831 to 0.850 +/- 0.014, and leakage decreased from 6.32% to 4.02% +/- 0.19%. However, these gains largely reflect increased training exposure rather than intrinsic synthetic data quality. Corpus diagnostics revealed systematic synthetic-real mismatches in note length and label distribution that align with persistent leakage. We conclude that synthetic augmentation is effective for expanding exposure but is complementary, not substitutive, for safety-critical veterinary de-identification.

cs.CR

Report of the Medical Image De-Identification (MIDI) Task Group -- Best Practices and Recommendations

This report addresses the technical aspects of de-identification of medical images of human subjects and biospecimens, such that re-identification risk of ethical, moral, and legal concern is sufficiently reduced to allow unrestricted public sharing for any purpose, regardless of the jurisdiction of the source and distribution sites. All medical images, regardless of the mode of acquisition, are considered, though the primary emphasis is on those with accompanying data elements, especially those encoded in formats in which the data elements are embedded, particularly Digital Imaging and Communications in Medicine (DICOM). These images include image-like objects such as Segmentations, Parametric Maps, and Radiotherapy (RT) Dose objects. The scope also includes related non-image objects, such as RT Structure Sets, Plans and Dose Volume Histograms, Structured Reports, and Presentation States. Only de-identification of publicly released data is considered, and alternative approaches to privacy preservation, such as federated learning for artificial intelligence (AI) model development, are out of scope, as are issues of privacy leakage from AI model sharing. Only technical issues of public sharing are addressed.

cs.CR

Whole Slide Image to DICOM Conversion as Event-Driven Cloud Infrastructure

The Digital Imaging and Communication in Medicine (DICOM) specification is increasingly being adopted in digital pathology to promote data standardization and interoperability. Efficient conversion of proprietary file formats into the DICOM standard format is a key requirement for institutional adoption of DICOM, necessary to ensure compatibility with existing scanners, microscopes, and data archives. Here, we present a cloud computing architecture for DICOM conversion, leveraging an event-driven microservices framework hosted in a serverless computing environment in Google Cloud to enable efficient DICOM conversion at scales ranging from individual images to institutional-scale datasets. In our experiments, employing a microservices-based approach substantially reduced runtime to process a batch of images relative to parallel and serial processing. This work demonstrates the importance of designing scalable systems for enabling enterprise-level adoption of digital pathology workflows, and provides a blueprint for using a microservice architecture to enable efficient DICOM conversion.

cs.DC