arXiv subjects

Davide Salzano

Publications and source records attributed to Davide Salzano.

10 recordsLinked to original sources

arXiv2026

Observing the state of networks with directed higher-order interactions

We consider the problem of reconstructing the state of a network of nonlinear dynamical systems in the presence of directed higher-order interactions. Grounded on analytical convergence results, we propose an algorithmic observer design procedure that simultaneously selects the nodes to be measured and the observer gains. We complement the theoretical analysis with an exhaustive numerical investigation campaign that showcases the performance and robustness of the designed observer. Finally, the algorithmic procedure is used to fully reconstruct the opinions of a group of agents.

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arXiv2026

Sparse shepherding control of large-scale multi-agent systems via Reinforcement Learning

We propose a Reinforcement Learning framework for sparse indirect control of large-scale multi-agent systems, where few controlled agents shape the collective behavior of many uncontrolled agents. The approach addresses this multi-scale challenge by coupling ODEs (modeling controlled agents) with a PDE (describing the uncontrolled population density), capturing how microscopic control achieves macroscopic objectives. Our method combines model-free Reinforcement Learning with adaptive interaction strength compensation to overcome sparse actuation limitations. Numerical validation demonstrates effective density control, with the system achieving target distributions while maintaining robustness to disturbances and measurement noise, confirming that learning-based sparse control can replace computationally expensive online optimization.

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arXiv2026

Robust multi-scale leader-follower control of large multi-agent systems

In many multi-agent systems of practical interest, such as traffic networks or crowd evacuation, control actions cannot be exerted on all agents. Instead, controllable leaders must indirectly steer uncontrolled followers through local interactions. Existing results address either leader-follower density control of simple, unperturbed multi-agent systems or robust density control of a single directly actuated population, but not their combination. We bridge this gap by deriving a coupled continuum description for leaders and followers subject to unknown bounded perturbations, and designing a macroscopic feedback law that guarantees global asymptotic convergence of the followers' density to a desired distribution. The coupled stability of the leader-follower system is analyzed via singular perturbation theory, and an explicit lower bound on the leader-to-follower mass ratio required for feasibility is derived. Numerical simulations on heterogeneous biased random walkers validate our theoretical findings.

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arXiv2026

Robust Macroscopic Density Control of Heterogeneous Multi-Agent Systems

Modern applications, such as orchestrating the collective behavior of robotic swarms or traffic flows, require the coordination of large groups of agents evolving in unstructured environments, where disturbances and unmodeled dynamics are unavoidable. In this work, we develop a scalable macroscopic density control framework in which a feedback law is designed directly at the level of an advection--diffusion partial differential equation. We formulate the control problem in the density space and prove global exponential convergence towards the desired behavior in $\mathcal{L}^2$ with guaranteed asymptotic rejection of bounded unknown drift terms, explicitly accounting for heterogeneous agent dynamics, unmodeled behaviors, and environmental perturbations. Our theoretical findings are corroborated by numerical experiments spanning heterogeneous oscillators, traffic systems, and swarm robotics in partially unknown environments.

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arXiv2025

A bioreactor-based architecture for in vivo model-based and sim-to-real learning control of microbial consortium composition

Microbial consortia offer significant biotechnological advantages over monocultures for bioproduction. However, industrial deployment is hampered by the lack of scalable architectures to ensure stable coexistence between populations. Existing strategies rely on genetic modifications, which impose metabolic load, or environmental changes, which can reduce production. We present a versatile control architecture to regulate density and composition of a two-strain consortium without genetic engineering or drastic environmental changes. Our bioreactor-based control architecture comprises a mixing chamber where both strains are co-cultured and a reservoir sustaining the slower-growing strain. For both chambers we develop model-based and sim-to-real learning controllers. The control architecture is then validated in vivo on a two-strain Escherichia coli consortium, achieving precise and robust regulation of consortium density and composition, including tracking of time-varying references and recovery from perturbations.

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arXiv2025

Controlling Complex Systems

This chapter provides a comprehensive overview of controlling collective behavior in complex systems comprising large ensembles of interacting dynamical agents. Building upon traditional control theory's foundation in individual systems, we introduce tools designed to address the unique challenges of coordinating networks that exhibit emergent phenomena, including consensus, synchronization, and pattern formation. We analyze how local agent interactions generate macroscopic behaviors and investigate the fundamental role of network topology in determining system dynamics. Inspired by natural systems, we emphasize control strategies that achieve global coordination through localized interventions while considering practical implementation challenges. The chapter concludes by presenting novel frameworks for managing very large agent ensembles and leveraging interacting networks for control purposes.

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arXiv2023

In vivo learning-based control of microbial populations density in bioreactors

A key problem toward the use of microorganisms as bio-factories is reaching and maintaining cellular communities at a desired density and composition so that they can efficiently convert their biomass into useful compounds. Promising technological platforms for the real time, scalable control of cellular density are bioreactors. In this work, we developed a learning-based strategy to expand the toolbox of available control algorithms capable of regulating the density of a \textit{single} bacterial population in bioreactors. Specifically, we used a sim-to-real paradigm, where a simple mathematical model, calibrated using a few data, was adopted to generate synthetic data for the training of the controller. The resulting policy was then exhaustively tested in vivo using a low-cost bioreactor known as Chi.Bio, assessing performance and robustness. In addition, we compared the performance with more traditional controllers (namely, a PI and an MPC), confirming that the learning-based controller exhibits similar performance in vivo. Our work showcases the viability of learning-based strategies for the control of cellular density in bioreactors, making a step forward toward their use for the control of the composition of microbial consortia.

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arXiv2022

External control of a genetic toggle switch via Reinforcement Learning

We investigate the problem of using a learning-based strategy to stabilize a synthetic toggle switch via an external control approach. To overcome the data efficiency problem that would render the algorithm unfeasible for practical use in synthetic biology, we adopt a sim-to-real paradigm where the policy is learnt via training on a simplified model of the toggle switch and it is then subsequently exploited to control a more realistic model of the switch parameterized from in-vivo experiments. Our in-silico experiments confirm the viability of the approach suggesting its potential use for in-vivo control implementations.

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arXiv2020

Intermittent yet coordinated regional strategies can alleviate the COVID-19 epidemic: a network model of the Italian case

The COVID-19 epidemic that emerged in Wuhan China at the end of 2019 hit Italy particularly hard, yielding the implementation of strict national lockdown rules (Phase 1). There is now a hot ongoing debate in Italy and abroad on what the best strategy is to restart a country to exit a national lockdown (Phase 2). Previous studies have focused on modelling possible restarting scenarios at the national level, overlooking the fact that Italy, as other nations around the world, is divided in administrative regions who can independently oversee their own share of the Italian National Health Service. In this study, we show that regionalism, and heterogeneity between regions, is essential to understand the spread of the epidemic and, more importantly, to design effective post Lock-Down strategies to control the disease. To achieve this, we model Italy as a network of regions and parameterize the model of each region on real data spanning almost two months from the initial outbreak. Using the model, we confirm the effectiveness at the regional level of the national lockdown strategy implemented so far by the Italian government to mitigate the spread of the disease and show its efficacy at the regional level. We also propose that differentiated, albeit coordinated, regional interventions can be effective in Phase 2 to restart the country and avoid future recurrence of the epidemic, while avoiding saturation of the regional health systems and mitigating impact on costs. Our study and methodology can be easily extended to other levels of granularity (provinces or counties in the same region or states in other federal countries, etc.) to support policy- and decision-makers.

physics.soc-ph↗

arXiv2019

Ratiometric control for differentiation of cell populations endowed with synthetic toggle switches

We consider the problem of regulating by means of external control inputs the ratio of two cell populations. Specifically, we assume that these two cellular populations are composed of cells belonging to the same strain which embeds some bistable memory mechanism, e.g. a genetic toggle switch, allowing them to switch role from one population to another in response to some inputs. We present three control strategies to regulate the populations' ratio to arbitrary desired values which take also into account realistic physical and technological constraints occurring in experimental microfluidic platforms. The designed controllers are then validated in-silico using stochastic agent-based simulations.

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