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Debdeep Pati

Publications and source records attributed to Debdeep Pati.

At least 19 recordsLinked to original sources

Posterior Tempering Explains Variance Inflation in Linear and Generalized Linear Thompson Sampling

We study a variant of the Thompson Sampling (TS) algorithm, called $\alpha$-TS, for solving stochastic generalized linear bandit problems. Existing analyses of TS require inflating the posterior variance to derive near-optimal regret guarantees. We formalize the idea of variance inflation by introducing $\alpha$-TS that uses a fractional or $\alpha$-posterior instead of the standard posterior. Our main contribution is to identify general regularity conditions on the prior and reward distributions that enable a regret analysis of $\alpha$-TS without assuming any tractable approximation of the posterior distribution, unlike previous works. For a specific choice of $\alpha \propto d^{-1}$, our general regret bound yields the best known regret bound of $O(d^{3/2}\sqrt{T}\log T)$ for both the exponential and sub-Gaussian families of reward distributions. We further provide an $\alpha$-dependent lower bound showing that the regret constant depends on the product $\alpha d$, and that when $\alpha \propto d^{-1}$ the regret scales as $\Omega(d^{3/2}\sqrt{T})$, explaining the origin of the $d^{3/2}$ factor in the upper bound. Our proof technique adapts and combines recent advancements in the analysis of linear bandit problems with first- and second-order posterior concentration theory from the Bayesian statistics literature.

stat.ML

Robust Bayesian Inference for Unnormalized Models with Mixed-Domain Data

Many statistical models involve parameter-dependent normalizing constants that are computationally intractable, creating substantial obstacles to standard Bayesian inference. Although existing likelihood-based algorithms can often circumvent these constants, their uncertainty quantification may be poorly calibrated under model misspecification. To address these challenges, we propose SME-BETEL, a semiparametric Bayesian framework that combines score matching estimating equations with Bayesian exponentially tilted empirical likelihood. The resulting posterior avoids evaluation of normalizing constants and does not require learning-rate calibration. We establish consistency and asymptotic normality of the score matching estimator, and prove a Bernstein-von Mises theorem for the SME-BETEL posterior. These results show that SME-BETEL credible sets are asymptotically calibrated to the sampling variability of the score matching estimator, yielding valid frequentist coverage under model misspecification. We further develop a new score matching criterion for mixed-domain data, extending SME-BETEL to models whose observations combine components from different sample spaces. This construction enables robust Bayesian inference for mixed-domain doubly-intractable models, including preferential sampling models with an intractable spatial normalizing integral. Simulation studies show that SME-BETEL remains competitive under correct specification and substantially improves uncertainty quantification under misspecification. An ozone-monitoring application further demonstrates the utility of the mixed-domain construction for spatial preferential modeling.

stat.ME

Robust Simulation Based Inference Through Robust Optimal Transport

When a statistical model $\{P_{\theta} : \theta \in \Theta\}$ lacks analytically tractable likelihoods, parametric statistical inference based on data generated from an unknown underlying distribution $P$ can still be performed as long as simulations from the model are possible. This approach is called Simulation Based Inference (SBI). Statistical models are rarely exactly correct (that is, $P \notin \{P_{\theta}: \theta \in \Theta\}$), and Robust SBI focuses on inferring a reasonable parameter even under model mis-specification. We focus on the setting where $P$ possesses potentially both geometric and Total Variation type discrepancies from $P_{\theta^*}$. For this problem, we use a Kullback-Liebler informed robust Optimal Transport divergence, motivated by Empirical Likelihood considerations. We introduce a stochastic sub-gradient ascent algorithm with a convergence guarantee for estimating the semi-discrete version of this robust Optimal Transport divergence, and design a parallelized SBI algorithm which employs the regular bootstrap on top of minimum semi-discrete robust Optimal Transport for parameter uncertainty quantification. We demonstrate mathematically why the divergence is robust under a joint geometric plus Total Variation type contamination and then illustrate the robustness of inferences on a complex benchmark SBI task.

stat.ME

Stability of Sequential and Parallel Coordinate Ascent Variational Inference

We highlight a striking difference in behavior between two widely used variants of coordinate ascent variational inference: the sequential and parallel algorithms. While such differences were known in the numerical analysis literature in simpler settings, they remain largely unexplored in the optimization-focused literature on variational inference in more complex models. Focusing on the moderately high-dimensional linear regression problem, we show that the sequential algorithm, although typically slower, enjoys convergence guarantees under more relaxed conditions than the parallel variant, which is often employed to facilitate block-wise updates and improve computational efficiency.

stat.ML

Frequentist Regret Analysis of Gaussian Process Thompson Sampling via Fractional Posteriors

We study Gaussian Process Thompson Sampling (GP-TS) for sequential decision-making over compact, continuous action spaces and provide a frequentist regret analysis based on fractional Gaussian process posteriors, without relying on domain discretization as in prior work. We show that the variance inflation commonly assumed in existing analyses of GP-TS can be interpreted as Thompson Sampling with respect to a fractional posterior with tempering parameter $\alpha \in (0,1)$. We derive a kernel-agnostic regret bound expressed in terms of the information gain parameter $\gamma_t$ and the posterior contraction rate $\epsilon_t$, and identify conditions on the Gaussian process prior under which $\epsilon_t$ can be controlled. As special cases of our general bound, we recover regret of order $\tilde{\mathcal{O}}(T^{\frac{1}{2}})$ for the squared exponential kernel, $\tilde{\mathcal{O}}(T^{\frac{2\nu+3d}{2(2\nu+d)}} )$ for the Mat\'ern-$\nu$ kernel, and a bound of order $\tilde{\mathcal{O}}(T^{\frac{2\nu+3d}{2(2\nu+d)}})$ for the rational quadratic kernel. Overall, our analysis provides a unified and discretization-free regret framework for GP-TS that applies broadly across kernel classes.

math.ST

Stationary Point Constrained Inference via Diffeomorphisms

Stationary points or derivative zero crossings of a regression function correspond to points where a trend reverses, making their estimation scientifically important. Existing approaches to uncertainty quantification for stationary points cannot deliver valid joint inference when multiple extrema are present, an essential capability in applications where the relative locations of peaks and troughs carry scientific significance. We develop a principled framework for functions with multiple regions of monotonicity by constraining the number of stationary points. We represent each function in the diffeomorphic formulation as the composition of a simple template and a smooth bijective transformation, and show that this parameterization enables coherent joint inference on the extrema. This construction guarantees a prespecified number of stationary points and provides a direct, interpretable parameterization of their locations. We derive non-asymptotic confidence bounds and establish approximate normality for the maximum likelihood estimators, with parallel results in the Bayesian setting. Simulations and an application to brain signal estimation demonstrate the method's accuracy and interpretability.

stat.ME

Global-Local Dirichlet Processes for Identifying Pan-Cancer Subpopulations Using Both Shared and Cancer-Specific Data

We consider the problem of clustering grouped data for which the observations may include group-specific variables in addition to the variables that are shared across groups. This type of data is common in cancer genomics where the molecular information is usually accompanied by cancer-specific clinical information. Existing grouped clustering methods only consider the shared variables, thereby ignoring valuable information from the cancer-specific variables. To allow for these cancer-specific variables to aid in the clustering, we propose a novel Bayesian nonparametric approach, termed global-local (GLocal) Dirichlet process, that models the ``global-local'' structure of the observations across groups. We characterize the GLocal Dirichlet process using the stick-breaking representation and the representation as a limit of a finite mixture model, which leads to an efficient posterior inference algorithm. We illustrate our model with extensive simulations and a real pan-gastrointestinal cancer dataset. The cancer-specific clinical variables included carcinoembryonic antigen level, patients' body mass index, and the number of cigarettes smoked per day. These important clinical variables refine the clusters of gene expression data and allow us to identify finer sub-clusters, which is not possible in their absence. This refinement aids in the better understanding of tumor progression and heterogeneity. Moreover, our proposed method is applicable beyond the field of cancer genomics to a general grouped clustering framework in the presence of group-specific idiosyncratic variables.

stat.ME

An Interpretable Single-Index Mixed-Effects Model for Non-Gaussian National Survey Data

This manuscript presents an innovative statistical model to quantify periodontal disease in the context of complex medical data. A mixed-effects model incorporating skewed random effects and heavy-tailed residuals is introduced, ensuring robust handling of non-normal data distributions. The fixed effect is modeled as a combination of a slope parameter and a single index function, constrained to be monotonic increasing for meaningful interpretation. This approach captures different dimensions of periodontal disease progression by integrating Clinical Attachment Level (CAL) and Pocket Depth (PD) biomarkers within a unified analytical framework. A variable selection method based on the grouped horseshoe prior is employed, addressing the relatively high number of risk factors. Furthermore, survey weight information typically provided with large survey data is incorporated to ensure accurate inference. This comprehensive methodology significantly advances the statistical quantification of periodontal disease, offering a nuanced and precise assessment of risk factors and disease progression. The proposed methodology is implemented in the \textsf{R} package \href{https://cran.r-project.org/package=MSIMST}{\textsc{MSIMST}}.

stat.ME

Probabilistic Symbolic Regression for Equation Discovery via Operator-induced and Regularized Symbolic Forests

Symbolic regression has emerged as a powerful tool for artificial intelligence-driven scientific discovery by learning interpretable analytical expressions that reveal governing relationships directly from data. Existing methods, however, often rely on heuristic search, struggle to balance predictive accuracy with expression complexity in noisy settings, and offer limited characterization of symbolic uncertainty. Probabilistic approaches that address these challenges in a unified manner remain underexplored. We introduce a probabilistic symbolic regression framework that represents mathematical expressions as ensembles of symbolic trees. A regularizing prior over tree topology controls expression complexity, while an Occam's window-based posterior summary captures uncertainty across multiple plausible symbolic models. Given the limited existing theoretical treatment of symbolic regression, we develop posterior concentration guarantees when symbolic expressions approximate the underlying relationship arbitrarily well, with a near-parametric rate when an exact finite formula exists. Additionally, we establish a sharp oracle concentration result under symbolic misspecification. Comparisons of our proposed framework with state-of-the-art competitors demonstrate superior predictive accuracy, optimal symbolic complexity, and stable structural recovery when learning benchmark scientific equations, together with the identification of scientifically interpretable descriptor formulas in a challenging materials discovery application.

stat.ME

On Quantification of Borrowing of Information in Hierarchical Bayesian Models

In this work, we offer a thorough analytical investigation into the role of shared hyperparameters in a hierarchical Bayesian model, examining their impact on information borrowing and posterior inference. Our approach is rooted in a non-asymptotic framework, where observations are drawn from a mixed-effects model, and a Gaussian distribution is assumed for the true effect generator. We consider a nested hierarchical prior distribution model to capture these effects and use the posterior means for Bayesian estimation. To quantify the effect of information borrowing, we propose an integrated risk measure relative to the true data-generating distribution. Our analysis reveals that the Bayes estimator for the model with a deeper hierarchy performs better, provided that the unknown random effects are correlated through a compound symmetric structure. Our work also identifies necessary and sufficient conditions for this model to outperform the one nested within it. We further obtain sufficient conditions when the correlation is perturbed. Our study suggests that the model with a deeper hierarchy tends to outperform the nested model unless the true data-generating distribution favors sufficiently independent groups. These findings have significant implications for Bayesian modeling, and we believe they will be of interest to researchers across a wide range of fields.

stat.ME

Adaptive Divide and Conquer with Two Rounds of Communication

We introduce a two-round adaptive communication strategy that enables rate-optimal estimation in the white noise model without requiring prior knowledge of the underlying smoothness. In the first round, local machines send summary statistics using $(\log_2(n))^2$ bits to enable the central machine to select the tuning parameters of the procedure. In the second round, another set of statistics are transmitted using optimal number of bits, enabling the central machine to aggregate and produce a final estimator that adapts to the true smoothness level. This approach achieves optimal convergence rates across a wider range of regularities, offering a potential improvement in the adaptability and efficiency of distributed estimation compared to existing one-round methods.

math.ST

A note on simulation methods for the Dirichlet-Laplace prior

Bhattacharya et al. (2015, Journal of the American Statistical Association 110(512): 1479-1490) introduce a novel prior, the Dirichlet-Laplace (DL) prior, and propose a Markov chain Monte Carlo (MCMC) method to simulate posterior draws under this prior in a conditionally Gaussian setting. The original algorithm samples from conditional distributions in the wrong order, i.e., it does not correctly sample from the joint posterior distribution of all latent variables. This note details the issue and provides two simple solutions: A correction to the original algorithm and a new algorithm based on an alternative, yet equivalent, formulation of the prior. This corrigendum does not affect the theoretical results in Bhattacharya et al. (2015).

stat.CO

A monotone single index model for spatially referenced multistate current status data

Assessment of multistate disease progression is commonplace in biomedical research, such as, in periodontal disease (PD). However, the presence of multistate current status endpoints, where only a single snapshot of each subject's progression through disease states is available at a random inspection time after a known starting state, complicates the inferential framework. In addition, these endpoints can be clustered, and spatially associated, where a group of proximally located teeth (within subjects) may experience similar PD status, compared to those distally located. Motivated by a clinical study recording PD progression, we propose a Bayesian semiparametric accelerated failure time model with an inverse-Wishart proposal for accommodating (spatial) random effects, and flexible errors that follow a Dirichlet process mixture of Gaussians. For clinical interpretability, the systematic component of the event times is modeled using a monotone single index model, with the (unknown) link function estimated via a novel integrated basis expansion and basis coefficients endowed with constrained Gaussian process priors. In addition to establishing parameter identifiability, we present scalable computing via a combination of elliptical slice sampling, fast circulant embedding techniques, and smoothing of hard constraints, leading to straightforward estimation of parameters, and state occupation and transition probabilities. Using synthetic data, we study the finite sample properties of our Bayesian estimates, and their performance under model misspecification. We also illustrate our method via application to the real clinical PD dataset.

stat.ME

Adaptive Resolution for Finite-Rank Gaussian Processes

Finite-rank approximations are widely used to scale Gaussian process (GP) regression, but their posterior behavior can differ from that of the corresponding parent GP prior. We study a class of finite-rank GP priors built from locally supported basis expansions with dependent Gaussian coefficients. Our framework covers finite-element approximations based on the stochastic partial differential equation (SPDE) representation of Mat\'ern GPs and regular-grid GP interpolation schemes. We show that, with a suitable prior on the resolution parameter $N$, these finite-rank expansions inherit the same posterior contraction rate as the corresponding parent GP prior under the same bandwidth specification used for that parent prior. Consequently, the interpolation construction under a squared-exponential parent GP attains the minimax-optimal rate up to logarithmic factors under a hierarchical prior on the bandwidth parameter and on $N$, while the SPDE construction attains the same rate under a bandwidth scaling depending on the sample size and the smoothness of the true function, together with a prior on $N$. We also develop a posterior sampler for the hierarchical interpolation model that jointly updates the resolution and bandwidth parameters, and we provide numerical studies that support the theory.

math.ST

Scalable Efficient Inference in Complex Surveys through Targeted Resampling of Weights

Survey data often arises from complex sampling designs, such as stratified or multistage sampling, with unequal inclusion probabilities. When sampling is informative, traditional inference methods yield biased estimators and poor coverage. Classical pseudo-likelihood based methods provide accurate asymptotic inference but lack finite-sample uncertainty quantification and the ability to integrate prior information. Existing Bayesian approaches, like the Bayesian pseudo-posterior estimator and weighted Bayesian bootstrap, have limitations; the former struggles with uncertainty quantification, while the latter is computationally intensive and sensitive to bootstrap replicates. To address these challenges, we propose the Survey-adjusted Weighted Likelihood Bootstrap (S-WLB), which resamples weights from a carefully chosen distribution centered around the underlying sampling weights. S-WLB is computationally efficient, theoretically consistent, and delivers finite-sample uncertainty intervals which are proven to be asymptotically valid. We demonstrate its performance through simulations and applications to nationally representative survey datasets like NHANES and NSDUH.

stat.ME

A Generalized Tangent Approximation based Variational Inference Framework for Strongly Super-Gaussian Likelihoods

Variational inference, as an alternative to Markov chain Monte Carlo sampling, has played a transformative role in enabling scalable computation for complex Bayesian models. Nevertheless, existing approaches often depend on either rigid model-specific formulations or stochastic black-box optimization routines. Tangent approximation is a principled class of structured variational methods that exploits the geometry of the underlying probability model. However, its utility has largely been confined to logistic regression and related modeling regimes. In this article, we propose a novel variational framework based on tangent transformation for a broad class of probability models characterized by strongly super-Gaussian likelihoods. Our method leverages convex duality to construct tangent minorants of the log-likelihood, thereby inducing conjugacy with Gaussian priors over model parameters in an otherwise intractable setup. Under mild assumptions on the data-generating mechanism, we establish algorithmic convergence guarantees, a contribution that stands in contrast to the limited theoretical assurances typically available for black-box variational methods. Additionally, we derive near-minimax optimal bounds for the variational risk. Superior performance of our proposed methodology is illustrated on simulated and real-data scenarios that challenge state-of-the-art variational algorithms in terms of scalability and their ability to consistently capture complex underlying data structure.

stat.ME

Robust Bayesian Inference on Riemannian Submanifold

Manifold-valued parameters routinely arise in modern statistical applications such as in medical imaging, robotics, and computer vision, to name a few. While traditional Bayesian approaches are applicable to such settings by considering an ambient Euclidean space as the parameter space, we demonstrate the benefits of integrating manifold structure into the Bayesian framework, both theoretically and computationally. Moreover, existing Bayesian approaches which are designed specifically for manifold-valued parameters are primarily model-based, which are typically subject to inaccurate uncertainty quantification under model misspecification. In this article, we propose a robust model-free Bayesian inference for parameters defined on a Riemannian submanifold, which is shown to provide valid uncertainty quantification from a frequentist perspective. Computationally, we propose a Markov chain Monte Carlo to sample from the posterior on the Riemannian submanifold, where the mixing time, in the large sample regime, is shown to depend only on the intrinsic dimension of the parameter space instead of the potentially muchlarger ambient dimension. Our numerical results demonstrate the effectiveness of our approach on a variety of problems, such as multiple quantile regression, reduced-rank regression, and Fr\'echet mean estimation.

stat.ME

Constrained Reweighting of Distributions: an Optimal Transport Approach

We commonly encounter the problem of identifying an optimally weight adjusted version of the empirical distribution of observed data, adhering to predefined constraints on the weights. Such constraints often manifest as restrictions on the moments, tail behaviour, shapes, number of modes, etc., of the resulting weight adjusted empirical distribution. In this article, we substantially enhance the flexibility of such methodology by introducing a nonparametrically imbued distributional constraints on the weights, and developing a general framework leveraging the maximum entropy principle and tools from optimal transport. The key idea is to ensure that the maximum entropy weight adjusted empirical distribution of the observed data is close to a pre-specified probability distribution in terms of the optimal transport metric while allowing for subtle departures. The versatility of the framework is demonstrated in the context of three disparate applications where data re-weighting is warranted to satisfy side constraints on the optimization problem at the heart of the statistical task: namely, portfolio allocation, semi-parametric inference for complex surveys, and ensuring algorithmic fairness in machine learning algorithms.

stat.ML