arXiv subjects

Debiao Li

Publications and source records attributed to Debiao Li.

17 recordsLinked to original sources

arXiv2026

Benchmarking Hybrid Deep Research Across Database Querying and Web Search

While autonomous agents have made significant strides in "deep research" by iteratively navigating the open web to synthesize information, real-world problem-solving is rarely confined to a single environment. Complex analytical tasks inherently require agents to weave together evidence from both ambiguous unstructured text (e.g., the open web) and highly precise structured data (e.g., relational databases). However, existing benchmarks evaluate these modalities in isolation, failing to capture the critical "handoff" - the ability to preserve constraints when moving evidence between systems. We introduce HybridDeepResearch, to our knowledge the first deep-research benchmark that requires both web search and SQL to form a complete, verifiable answer. The benchmark contains 380 tool-dependent tasks grounded in LiveSQLBench-Base-Lite databases and public web corpora, validated through automated checks and human review, and covering three reasoning patterns: SQL2S, S2SQL, and Parallel. Evaluations across proprietary and open-weight models under various agentic scaffolds reveal that even state-of-the-art models like GLM-5.2, Claude-Sonnet-4.6 and GPT-5 achieve only about 50-54% Pass@8 on the hard subset. Notably, results show that directional reasoning is substantially more difficult than parallel intersection, highlighting that bridging structured and unstructured information spaces without losing constraints remains a major open challenge for agentic systems. Code and datasets are publicly available at GitHub (https://github.com/Snowflake-AI-Research/HybridDeepResearch) and Hugging Face (https://huggingface.co/datasets/Snowflake/HybridDeepResearch).

cs.CL↗

arXiv2026

AtlasGS: Brain MRI Spatial Resolution Harmonization With Shared Gaussian Geometry

Splatting (GS)-based shared geometry framework adopts a two-stage training strategy, in which an explicit, subject-specific Gaussian scaffold encoding anatomical geometry is first learned from the isotropic structural scan and then reused to fit appearance for target modalities acquired with sparse slices. Experiments on the UK Biobank, GBM, and ABCD datasets for through-plane super-resolution across multiple modalities (T2-weighted, FLAIR, DWI, ASL), degradation factors ($\times 3$, $\times 5$, $\times 7$), and pathological abnormalities (glioblastoma) demonstrate state-of-the-art reconstruction fidelity. The shared Gaussian geometry enables arbitrary-view generation for target modalities with strong structural consistency and further shows potential for self-supervised in-plane super-resolution. This work establishes explicit geometry-guided representations as a novel, flexible, and interpretable pathway toward retrospective multi-contrast MRI harmonization and reliable clinical reference construction. Source code is available at: https://github.com/yfgao76/AtlasGS

eess.IV↗

arXiv2026

AutoIQ: An Ensemble Framework for Automatic Assessment of Geometric Distortion in Prostate Diffusion-Weighted Imaging

Geometric distortion in prostate diffusion-weighted imaging (DWI) can impair lesion localization and reduce the reliability of MRI-based clinical assessment. We propose AutoIQ, an ensemble machine learning framework for automatic quantification and classification of DWI geometric distortion severity. A total of 140 retrospective prostate biparametric MRI examinations were analyzed, including 33 scans with severe distortion requiring repeat acquisition and 107 scans with acceptable distortion based on expert radiologist assessment. AutoIQ combines two complementary distortion quantification strategies: a segmentation-based method measuring prostate boundary mismatch between T2-weighted imaging (T2WI) and DWI, and a registration-based method estimating deformation magnitude after DWI-to-T2WI alignment. The resulting distortion scores were used to train individual classifiers and a logistic-regression ensemble model. Both computational methods significantly differentiated severe from acceptable distortion cases (p < 0.001). On an independent test set, the ensemble model achieved an accuracy of 0.95, F1-score of 0.93, and AUC of 0.98, outperforming individual models. These results suggest that AutoIQ can provide automated, quantitative quality assessment for prostate DWI and may help identify scans that require repeat acquisition.

eess.IV↗

arXiv2026

BCER Agent: Reliable Long-Horizon MRI Workflow Execution via Compilation, Artifact Binding, and Bounded Local Recovery

Many recent medical VLM and agent studies are benchmarked on 2D images or comparatively short tool-calling exchanges, whereas real MRI analysis typically demands long, interdependent pipelines that operate on 3D/4D volumetric data. Under these conditions, reactive tool-calling agents are prone to cascading breakdowns triggered by faulty intermediate references, mismatched tool arguments, and limited control over cross-step dependencies. To address this, we introduce BCER (Brain-Cerebellum-Extremity-Reflector), a controller architecture aimed at dependable long-horizon MRI workflow execution. BCER decouples high-level planning from execution and provides bounded local recovery. We assess BCER on a multi-organ MRI benchmark covering brain, prostate, and cardiac tasks with both short- and long-chain workflows, using matched task contracts across controller variants and several backbone models. Relative to reactive baselines, BCER yields consistent improvements in end-to-end execution, with the most pronounced gains observed on long-chain workflows. BCER additionally enables auditability by maintaining explicit links between final outputs and intermediate artifacts and measurements. Code and benchmark are released at https://github.com/Albertlongzi/BCER.

eess.IV↗

arXiv2026

From Global Radiomics to Parametric Maps: A Unified Workflow Fusing Radiomics and Deep Learning for PDAC Detection

Radiomics and deep learning both offer powerful tools for quantitative medical imaging, but most existing fusion approaches only leverage global radiomic features and overlook the complementary value of spatially resolved radiomic parametric maps. We propose a unified framework that first selects discriminative radiomic features and then injects them into a radiomics-enhanced nnUNet at both the global and voxel levels for pancreatic ductal adenocarcinoma (PDAC) detection. On the PANORAMA dataset, our method achieved AUC = 0.96 and AP = 0.84 in cross-validation. On an external in-house cohort, it achieved AUC = 0.95 and AP = 0.78, outperforming the baseline nnUNet; it also ranked second in the PANORAMA Grand Challenge. This demonstrates that handcrafted radiomics, when injected at both global and voxel levels, provide complementary signals to deep learning models for PDAC detection. Our code can be found at https://github.com/briandzt/dl-pdac-radiomics-global-n-paramaps

eess.IV↗

arXiv2026

Let Distortion Guide Restoration (DGR): A physics-informed learning framework for Prostate Diffusion MRI

We present Distortion-Guided Restoration (DGR), a physics-informed hybrid CNN-diffusion framework for acquisition-free correction of severe susceptibility-induced distortions in prostate single-shot EPI diffusion-weighted imaging (DWI). DGR is trained to invert a realistic forward distortion model using large-scale paired distorted and undistorted data synthesized from distortion-free prostate DWI and co-registered T2-weighted images from 410 multi-institutional studies, together with 11 measured B0 field maps from metal-implant cases incorporated into a forward simulator to generate low-b DWI (b = 50 s per mm squared), high-b DWI (b = 1400 s per mm squared), and ADC distortions. The network couples a CNN-based geometric correction module with conditional diffusion refinement under T2-weighted anatomical guidance. On a held-out synthetic validation set (n = 34) using ground-truth simulated distortion fields, DGR achieved higher PSNR and lower NMSE than FSL TOPUP and FUGUE. In 34 real clinical studies with severe distortion, including hip prostheses and marked rectal distension, DGR improved geometric fidelity and increased radiologist-rated image quality and diagnostic confidence. Overall, learning the inverse of a physically simulated forward process provides a practical alternative to acquisition-dependent distortion-correction pipelines for prostate DWI.

eess.IV↗

arXiv2025

Hybrid Reward Normalization for Process-supervised Non-verifiable Agentic Tasks

Large Language Models (LLMs) increasingly rely on external tools such as search engines to solve complex agentic tasks that require reasoning and external knowledge retrieval. Recently, reinforcement learning with verifiable rewards (RLVR) has demonstrated its effectiveness in advancing capabilities of LLMs by rewarding the final answers via outcome rewards. While straightforward to supervise, outcome rewards only provide sparse signals and delayed feedback, which limits their effectiveness on long trajectories. Process rewards address this by evaluating intermediate steps, providing fine-grained supervision and encouraging grounded problem solving. However, it is notoriously hard to annotate step-wise labels, especially in non-verifiable process without "golden" answers. Furthermore, step-wise judgment requires the balance between local quality with contribution to the final outcome, as optimizing towards higher process reward may not always align with better final outcomes. To address the above challenges, we introduce Principle Process Reward (PPR), an RL approach that unifies principled step-level assessment and outcome verification. We train a principle-based reward model to improve the transparency and reliability of process evaluation, and further introduce a Reward Normalization (ReNorm) strategy to calibrate outcome and process rewards. Experiment results show that PPR achieves state-of-the-art performance across a wide range of benchmarks, demonstrating its impressive robustness and generalization. Our code and model collection is available in this link.

cs.AI↗

arXiv2024

EchoPrime: A Multi-Video View-Informed Vision-Language Model for Comprehensive Echocardiography Interpretation

Echocardiography is the most widely used cardiac imaging modality, capturing ultrasound video data to assess cardiac structure and function. Artificial intelligence (AI) in echocardiography has the potential to streamline manual tasks and improve reproducibility and precision. However, most echocardiography AI models are single-view, single-task systems that do not synthesize complementary information from multiple views captured during a full exam, and thus lead to limited performance and scope of applications. To address this problem, we introduce EchoPrime, a multi-view, view-informed, video-based vision-language foundation model trained on over 12 million video-report pairs. EchoPrime uses contrastive learning to train a unified embedding model for all standard views in a comprehensive echocardiogram study with representation of both rare and common diseases and diagnoses. EchoPrime then utilizes view-classification and a view-informed anatomic attention model to weight video-specific interpretations that accurately maps the relationship between echocardiographic views and anatomical structures. With retrieval-augmented interpretation, EchoPrime integrates information from all echocardiogram videos in a comprehensive study and performs holistic comprehensive clinical echocardiography interpretation. In datasets from two independent healthcare systems, EchoPrime achieves state-of-the art performance on 23 diverse benchmarks of cardiac form and function, surpassing the performance of both task-specific approaches and prior foundation models. Following rigorous clinical evaluation, EchoPrime can assist physicians in the automated preliminary assessment of comprehensive echocardiography.

cs.CV↗

arXiv2022

Data-Consistent Non-Cartesian Deep Subspace Learning for Efficient Dynamic MR Image Reconstruction

Non-Cartesian sampling with subspace-constrained image reconstruction is a popular approach to dynamic MRI, but slow iterative reconstruction limits its clinical application. Data-consistent (DC) deep learning can accelerate reconstruction with good image quality, but has not been formulated for non-Cartesian subspace imaging. In this study, we propose a DC non-Cartesian deep subspace learning framework for fast, accurate dynamic MR image reconstruction. Four novel DC formulations are developed and evaluated: two gradient decent approaches, a directly solved approach, and a conjugate gradient approach. We applied a U-Net model with and without DC layers to reconstruct T1-weighted images for cardiac MR Multitasking (an advanced multidimensional imaging method), comparing our results to the iteratively reconstructed reference. Experimental results show that the proposed framework significantly improves reconstruction accuracy over the U-Net model without DC, while significantly accelerating the reconstruction over conventional iterative reconstruction.

eess.IV↗

arXiv2020

Cine Cardiac MRI Motion Artifact Reduction Using a Recurrent Neural Network

Cine cardiac magnetic resonance imaging (MRI) is widely used for diagnosis of cardiac diseases thanks to its ability to present cardiovascular features in excellent contrast. As compared to computed tomography (CT), MRI, however, requires a long scan time, which inevitably induces motion artifacts and causes patients' discomfort. Thus, there has been a strong clinical motivation to develop techniques to reduce both the scan time and motion artifacts. Given its successful applications in other medical imaging tasks such as MRI super-resolution and CT metal artifact reduction, deep learning is a promising approach for cardiac MRI motion artifact reduction. In this paper, we propose a recurrent neural network to simultaneously extract both spatial and temporal features from under-sampled, motion-blurred cine cardiac images for improved image quality. The experimental results demonstrate substantially improved image quality on two clinical test datasets. Also, our method enables data-driven frame interpolation at an enhanced temporal resolution. Compared with existing methods, our deep learning approach gives a superior performance in terms of structural similarity (SSIM) and peak signal-to-noise ratio (PSNR).

eess.IV↗

arXiv2020

MRI Super-Resolution with GAN and 3D Multi-Level DenseNet: Smaller, Faster, and Better

High-resolution (HR) magnetic resonance imaging (MRI) provides detailed anatomical information that is critical for diagnosis in the clinical application. However, HR MRI typically comes at the cost of long scan time, small spatial coverage, and low signal-to-noise ratio (SNR). Recent studies showed that with a deep convolutional neural network (CNN), HR generic images could be recovered from low-resolution (LR) inputs via single image super-resolution (SISR) approaches. Additionally, previous works have shown that a deep 3D CNN can generate high-quality SR MRIs by using learned image priors. However, 3D CNN with deep structures, have a large number of parameters and are computationally expensive. In this paper, we propose a novel 3D CNN architecture, namely a multi-level densely connected super-resolution network (mDCSRN), which is light-weight, fast and accurate. We also show that with the generative adversarial network (GAN)-guided training, the mDCSRN-GAN provides appealing sharp SR images with rich texture details that are highly comparable with the referenced HR images. Our results from experiments on a large public dataset with 1,113 subjects showed that this new architecture outperformed other popular deep learning methods in recovering 4x resolution-downgraded images in both quality and speed.

cs.CV↗

arXiv2019

Fully Automated Multi-Organ Segmentation in Abdominal Magnetic Resonance Imaging with Deep Neural Networks

Segmentation of multiple organs-at-risk (OARs) is essential for radiation therapy treatment planning and other clinical applications. We developed an Automated deep Learning-based Abdominal Multi-Organ segmentation (ALAMO) framework based on 2D U-net and a densely connected network structure with tailored design in data augmentation and training procedures such as deep connection, auxiliary supervision, and multi-view. The model takes in multi-slice MR images and generates the output of segmentation results. Three-Tesla T1 VIBE (Volumetric Interpolated Breath-hold Examination) images of 102 subjects were collected and used in our study. Ten OARs were studied, including the liver, spleen, pancreas, left/right kidneys, stomach, duodenum, small intestine, spinal cord, and vertebral bodies. Two radiologists manually labeled and obtained the consensus contours as the ground-truth. In the complete cohort of 102, 20 samples were held out for independent testing, and the rest were used for training and validation. The performance was measured using volume overlapping and surface distance. The ALAMO framework generated segmentation labels in good agreement with the manual results. Specifically, among the 10 OARs, 9 achieved high Dice Similarity Coefficients (DSCs) in the range of 0.87-0.96, except for the duodenum with a DSC of 0.80. The inference completes within one minute for a 3D volume of 320x288x180. Overall, the ALAMO model matches the state-of-the-art performance. The proposed ALAMO framework allows for fully automated abdominal MR segmentation with high accuracy and low memory and computation time demands.

eess.IV↗

arXiv2019

Deep learning within a priori temporal feature spaces for large-scale dynamic MR image reconstruction: Application to 5-D cardiac MR Multitasking

High spatiotemporal resolution dynamic magnetic resonance imaging (MRI) is a powerful clinical tool for imaging moving structures as well as to reveal and quantify other physical and physiological dynamics. The low speed of MRI necessitates acceleration methods such as deep learning reconstruction from under-sampled data. However, the massive size of many dynamic MRI problems prevents deep learning networks from directly exploiting global temporal relationships. In this work, we show that by applying deep neural networks inside a priori calculated temporal feature spaces, we enable deep learning reconstruction with global temporal modeling even for image sequences with >40,000 frames. One proposed variation of our approach using dilated multi-level Densely Connected Network (mDCN) speeds up feature space coordinate calculation by 3000x compared to conventional iterative methods, from 20 minutes to 0.39 seconds. Thus, the combination of low-rank tensor and deep learning models not only makes large-scale dynamic MRI feasible but also practical for routine clinical application.

eess.IV↗

arXiv2018

Efficient and Accurate MRI Super-Resolution using a Generative Adversarial Network and 3D Multi-Level Densely Connected Network

High-resolution (HR) magnetic resonance images (MRI) provide detailed anatomical information important for clinical application and quantitative image analysis. However, HR MRI conventionally comes at the cost of longer scan time, smaller spatial coverage, and lower signal-to-noise ratio (SNR). Recent studies have shown that single image super-resolution (SISR), a technique to recover HR details from one single low-resolution (LR) input image, could provide high-quality image details with the help of advanced deep convolutional neural networks (CNN). However, deep neural networks consume memory heavily and run slowly, especially in 3D settings. In this paper, we propose a novel 3D neural network design, namely a multi-level densely connected super-resolution network (mDCSRN) with generative adversarial network (GAN)-guided training. The mDCSRN quickly trains and inferences and the GAN promotes realistic output hardly distinguishable from original HR images. Our results from experiments on a dataset with 1,113 subjects show that our new architecture beats other popular deep learning methods in recovering 4x resolution-downgraded im-ages and runs 6x faster.

cs.CV↗

arXiv2018

Calcium Removal From Cardiac CT Images Using Deep Convolutional Neural Network

Coronary calcium causes beam hardening and blooming artifacts on cardiac computed tomography angiography (CTA) images, which lead to overestimation of lumen stenosis and reduction of diagnostic specificity. To properly remove coronary calcification and restore arterial lumen precisely, we propose a machine learning-based method with a multi-step inpainting process. We developed a new network configuration, Dense-Unet, to achieve optimal performance with low computational cost. Results after the calcium removal process were validated by comparing with gold-standard X-ray angiography. Our results demonstrated that removing coronary calcification from images with the proposed approach was feasible, and may potentially improve the diagnostic accuracy of CTA.

cs.CV↗

arXiv2018

Accelerated Cardiac Diffusion Tensor Imaging Using Joint Low-Rank and Sparsity Constraints

Objective: The purpose of this manuscript is to accelerate cardiac diffusion tensor imaging (CDTI) by integrating low-rankness and compressed sensing. Methods: Diffusion-weighted images exhibit both transform sparsity and low-rankness. These properties can jointly be exploited to accelerate CDTI, especially when a phase map is applied to correct for the phase inconsistency across diffusion directions, thereby enhancing low-rankness. The proposed method is evaluated both ex vivo and in vivo, and is compared to methods using either a low-rank or sparsity constraint alone. Results: Compared to using a low-rank or sparsity constraint alone, the proposed method preserves more accurate helix angle features, the transmural continuum across the myocardium wall, and mean diffusivity at higher acceleration, while yielding significantly lower bias and higher intraclass correlation coefficient. Conclusion: Low-rankness and compressed sensing together facilitate acceleration for both ex vivo and in vivo CDTI, improving reconstruction accuracy compared to employing either constraint alone. Significance: Compared to previous methods for accelerating CDTI, the proposed method has the potential to reach higher acceleration while preserving myofiber architecture features which may allow more spatial coverage, higher spatial resolution and shorter temporal footprint in the future.

eess.SP↗

arXiv2018

Brain MRI Super Resolution Using 3D Deep Densely Connected Neural Networks

Magnetic resonance image (MRI) in high spatial resolution provides detailed anatomical information and is often necessary for accurate quantitative analysis. However, high spatial resolution typically comes at the expense of longer scan time, less spatial coverage, and lower signal to noise ratio (SNR). Single Image Super-Resolution (SISR), a technique aimed to restore high-resolution (HR) details from one single low-resolution (LR) input image, has been improved dramatically by recent breakthroughs in deep learning. In this paper, we introduce a new neural network architecture, 3D Densely Connected Super-Resolution Networks (DCSRN) to restore HR features of structural brain MR images. Through experiments on a dataset with 1,113 subjects, we demonstrate that our network outperforms bicubic interpolation as well as other deep learning methods in restoring 4x resolution-reduced images.

cs.CV↗