Debomita Chakraborty | Searcharxiv

arXiv2026

On Strong Bi-Lipschitz Triviality of Deformations

The Thom-Levine theorem is a classical method for proving the triviality of deformations by integrating suitable vector fields. In this note, we show that the converse of this criterion does not hold in the bi-Lipschitz category. More precisely, we give an example of a smooth one-parameter deformation of a real function germ in two variables which is bi-Lipschitz trivial but not strongly bi-Lipschitz trivial. The central germ has an isolated critical point, though it is not finitely determined.

math.MG↗

arXiv2021

Designing biological circuits: from principles to applications

Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first genetic circuits -- the repressilator and the toggle switch -- were designed and implemented, many advances have been made in this area of research. The current review systematically organizes a number of key works in this domain by employing the versatile framework of generalized morphological analysis. Literature in the area has been mapped based on (a) the design methodologies used, ranging from brute-force searches to control-theoretic approaches, (b) the modelling techniques employed, (c) various circuit functionalities implemented, (d) key design characteristics, and (e) the strategies used for the robust design of genetic circuits. We conclude our review with an outlook on multiple exciting areas for future research, based on the systematic assessment of key research gaps that have been readily unravelled by our analysis framework.

q-bio.MN↗