arXiv subjects

Dehao Wu

Publications and source records attributed to Dehao Wu.

4 recordsLinked to original sources

arXiv2026

Agentic AI uncovers conserved cross-tissue protein co-abundance programs inaccessible to single-dataset analysis

Protein co-abundance clusters preserved across tissues can reveal shared disease mechanisms and candidate therapeutic targets, particularly when proteins implicated in organ-confined diseases converge in peripheral or accessible tissues. However, previous cross-tissue studies have focused on biologically pre-selected tissue pairs, leaving most possible combinations and non-obvious relationships unexplored. We present an LLM-agent framework for large-scale, evidence-grounded comparison of tissue-specific protein co-abundance networks. The framework constructs tissue networks, derives pairwise consensus clusters, and integrates evidence from expression atlases, protein interaction and complex databases, pathway annotations, disease catalogues, and literature. Applied to all 820 pairwise combinations of 41 human tissues and fluids, it identified 1,833 conserved co-abundance clusters across 406 tissue pairs. Colon, synovial fluid, blood, cerebrospinal fluid, and bone marrow were the most broadly connected tissues, while the most cluster-rich pairs were dominated by bone marrow. The analysis also highlighted non-obvious relationships: skin-bone marrow exceeded the anatomically adjacent bone-bone marrow pair, while colon-breast contained cancer-relevant clusters involving extracellular-matrix remodeling, lipid metabolism, and immune modulation. Cluster-level analyses generated further mechanistic hypotheses, including a brain-gut extracellular-vesicle/redox/serotonin-cofactor axis and a liver-bone marrow stress-response axis involving genes linked to white matter disease. These results provide a global, comparable landscape of conserved protein co-abundance and a hypothesis-generating resource for mechanistic and therapeutic exploration. Code and data are available at https://github.com/Gry1005/AgenticAI-conserved-cross-tissue-protein-co-abundance.

cs.AI↗

arXiv2024

Dynamic Dimension Wrapping (DDW) Algorithm: A Novel Approach for Efficient Cross-Dimensional Search in Dynamic Multidimensional Spaces

To effectively search for the optimal motion template in dynamic multidimensional space, this paper proposes a novel optimization algorithm, Dynamic Dimension Wrapping (DDW).The algorithm combines Dynamic Time Warping (DTW) and Euclidean distance, and designs a fitness function that adapts to dynamic multidimensional space by establishing a time-data chain mapping across dimensions. This paper also proposes a novel update mechanism,Optimal Dimension Collection (ODC), combined with the search strategy of traditional optimization algorithms, enables DDW to adjust both the dimension values and the number of dimensions of the population individuals simultaneously. In this way, DDW significantly reduces computational complexity and improves search accuracy. Experimental results show that DDW performs excellently in dynamic multidimensional space, outperforming 31 traditional optimization algorithms. This algorithm provides a novel approach to solving dynamic multidimensional optimization problems and demonstrates broad application potential in fields such as motion data analysis.

cs.LG↗

arXiv2019

An Adaptive Deep Learning Algorithm Based Autoencoder for Interference Channels

Deep learning (DL) based autoencoder has shown great potential to significantly enhance the physical layer performance. In this paper, we present a DL based autoencoder for interference channel. Based on a characterization of a k-user Gaussian interference channel, where the interferences are classified as different levels from weak to very strong interferences based on a coupling parameter α, a DL neural network (NN) based autoencoder is designed to train the data set and decode the received signals. The performance such a DL autoencoder for different interference scenarios are studied, with α known or partially known, where we assume that α is predictable but with a varying up to 10\% at the training stage. The results demonstrate that DL based approach has a significant capability to mitigate the effect induced by a poor signal-to-noise ratio (SNR) and a high interference-to-noise ratio (INR). However, the enhancement depends on the knowledge of α as well as the interference levels. The proposed DL approach performs well with α up to 10\% offset for weak interference level. For strong and very strong interference channel, the offset of α needs to be constrained to less than 5\% and 2\%, respectively, to maintain similar performance as α is known.

cs.LG↗

arXiv2019

Reconfigurable Liquid Crystal Reflectarray Metasurface for THz Communications

We present computational studies on a proposed 20 by 20 elements electronically reconfigurable liquid crystal (LC) based binary phase reflectarray metasurface, operational at 108 GHz. LC was modelled after Mer's GT3-23001, and full wave simulations have shown a phase difference of 177 degrees between ON and OFF states, while reflection amplitudes were both 0.88 for ON and OFF. We present preliminary full wave simulation results on the Genetic Algorithm (GA) optimised far-fields. We also present the basic design procedures and cross-platform implementations on optimisation routines involving Matlab, CST and VBA environments.

physics.app-ph↗