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Delphine Salort

Publications and source records attributed to Delphine Salort.

17 recordsLinked to original sources

Asymptotic dynamics of inhibitory networks for the NNLIF Model in the large-delay limit

We investigate the impact of large synaptic delays on the emergence of periodic dynamics in inhibitory neuronal networks, within the framework of the NNLIF model. Inspired by the work of [11] where the notion of pseudo-equilibria was introduced and developed, and by our earlier analysis in [14], we show that, as the delay tends to infinity, solutions of sufficitently inhibitory networks oscillate between distinct pseudo-equilibria over any finite time interval. Employing the Doeblin-Harris method, we rigorously establish a local convergence in the Ces{\`a}ro mean toward a limit function determined solely by these pseudo-equilibria.

math.AP

A Fokker-Planck equation with superlinear drift at infinity for Integrate-and-Fire model

The Integrate-and-Fire model is a Fokker-Planck equation arising in neuroscience. It describes the evolution of the probability density of the neuronal membrane potential and fitting has shown that the inclusion of a em superlinear drift provides the most realistic description. To make sense of this, we propose to set the equation on the full line, the neural activity being described by the flux at infinity. This framework serves as a model extension of the classical Noisy Integrate-and-Fire model, with a fixed firing potential. We first establish the well-posedness of the solution, establish the boundary condition at infinity which is the major difficulty. Then, state rigorously the entropy dissipation property. Finally, using Doeblin's method, we prove the exponential convergence of the solution toward the unique stationary state in full generality.

math.AP

On partial diffusion and mixing without hypoellipticity

A simple Markov process is considered involving a diffusion in one direction and a transport in a transverse direction. Quantitative mixing rate estimates are obtained with limited assumptions about the transport field, which might be highly irregular and/or highly degenerate, in particular quite far from satisfying an hypoellipticity type assumption.

math.AP

Strongly nonlinear age structured equation,time-elapsed model and large delays

The time-elapsed model for neural networks is a nonlinear age structured equationwhere the renewal term describes the network activity and influences the dischargerate, possibly with a delay due to the length of connections.We solve a long standing question, namely that an inhibitory network withoutdelay will converge to a steady state and thus the network is desynchonised. Ourapproach is based on the observation that a non-expansion property holds true.However a non-degeneracy condition is needed and, besides the standard one, weintroduce a new condition based on strict nonlinearity.When a delay is included, and following previous works for Fokker-Planck models,we prove that the network may generate periodic solutions. We introduce a newformalism to establish rigorously this property for large delays.The fundamental contraction property also holds for some other age structuredequations and systems.

math.AP

Noisy integrate-and-fire equation: continuation after blow-up

The integrate and fire equation is a classical model for neural assemblies which can exhibit finite time blow-up. A major open problem is to understand how to continue solutions after blow-up. Here we study an approach based on random discharge models and a change of time which generates a classical global solution to the expense of a strong absorption rate 1/$ε$. We prove that in the limit $ε$ $\rightarrow$ 0 + , a global solution is recovered where the integrate and fire equation is reformulated with a singular measure. This describes the dynamics after blow-up and also gives information on the blow-up phenomena itself.The major difficulty is to handle nonlinear terms. To circumvent it, we establish two new estimates, a kind of equi-integrability of the discharge measure and a L 2 estimate of the density. The use of the new timescale turns out to be fundamental for those estimates.

math.AP

An infinite-times renewal equation

In neuroscience, the time elapsed since the last discharge has been used to predict the probability of the next discharge. Such predictions can be improved taking into account the last two discharge times, and possibly more. Such multi-time processes arise in many other areas and there is no universal limitation on the number of times to be used. This observation leads us to study the infinite-times renewal equation as a simple model to understand the meaning and properties of such partial differential equations depending on an infinite number of variables.We define two notions of solutions, prove existence and uniqueness of solutions, possibly measures. We also prove the long time convergence, with exponential rate, to the steady state in different, strong or weak, topologies depending on assumptions on the coefficients.

math.AP

Bounds and long term convergence for the voltage-conductance kinetic system arising in neuroscience

The voltage-conductance equation determines the probability distribution of a stochastic process describing a fluctuation-driven neuronal network arising in the visual cortex. Its structure and degeneracy share many common features with the kinetic Fokker-Planck equation, which has attracted much attention recently. We prove an L $\infty$ bound on the steady state solution and the long term convergence of the evolution problem towards this stationary state. Despite the hypoellipticity property, the difficulty is to treat the boundary conditions that change type along the boundary. This leads us to use specific weights in the Alikakos iterations and adapt the relative entropy method.

math.AP

A multiple time renewal equation for neural assemblies with elapsed time model

We introduce and study an extension of the classical elapsed time equation in the context of neuron populations that are described by the elapsed time since the last discharge, i.e., the refractory period. In this extension we incorporate the elapsed since the penultimate discharge and we obtain a more complex system of integro-differential equations. For this new system we prove convergence to stationary state by means of Doeblin's theory in the case of weak non-linearities in an appropriate functional setting, inspired by the case of the classical elapsed time equation. Moreover, we present some numerical simulations to observe how different firing rates can give different types of behaviors and to contrast them with theoretical results of both classical and extended models.

math.AP

An elapsed time model for strongly coupled inhibitory and excitatory neural networks

The elapsed time model has been widely studied in the context of mathematical neuroscience with many open questions left. The model consists of an age-structured equation that describes the dynamics of interacting neurons structured by the elapsed time since their last discharge. Our interest lies in highly connected networks leading to strong nonlinearities where perturbation methods do not apply. To deal with this problem, we choose a particular case which can be reduced to delay equations. We prove a general convergence result to a stationary state in the inhibitory and the weakly excitatory cases. Moreover, we prove the existence of particular periodic solutions with jump discontinuities in the strongly excitatory case. Finally, we present some numerical simulations which ilustrate various behaviors, which are consistent with the theoretical results.

math.AP

Dynamics of neural networks with elapsed time model and learning processes

We introduce and study a new model of interacting neural networks, incorporating the spatial dimension (e.g. position of neurons across the cortex) and some learning processes. The dynamic of each neural network is described via the elapsed time model, that is, the neurons are described by the elapsed time since their last discharge and the chosen learning processes are essentially inspired from the Hebbian rule. We then obtain a system of integro-differential equations, from which we analyze the convergence to stationary states by the means of entropy method and Doeblin's theory in the case of weak interconnections. We also consider the situation where neural activity is faster than the learning process and give conditions where one can approximate the dynamics by a solution with a similar profile of a steady state. For stronger interconnections, we present some numerical simulations to observe how the parameters of the system can give different behaviors and pattern formations.

math.AP

Global-in-time classical solutions and qualitative properties for the NNLIF neuron model with synaptic delay

The Nonlinear Noisy Leaky Integrate and Fire (NNLIF) model is widely used to describe the dynamics of neural networks after a diffusive approximation of the mean-field limit of a stochastic differential equation system. When the total activity of the network has an instantaneous effect on the network, in the average-excitatory case, a blow-up phenomenon occurs. This article is devoted to the theoretical study of the NNLIF model in the case where a delay in the effect of the total activity on the neurons is added. We first prove global-in-time existence and uniqueness of classical solutions, independently of the sign of the connectivity parameter, that is, for both cases: excitatory and inhibitory. Secondly, we prove some qualitative properties of solutions: asymptotic convergence to the stationary state for weak interconnections and a non-existence result for periodic solutions if the connectivity parameter is large enough. The proofs are mainly based on an appropriate change of variables to rewrite the NNLIF equation as a Stefan-like free boundary problem, constructions of universal super-solutions, the entropy dissipation method and Poincaré's inequality.

math.AP

A model for cost efficient Workforce Organizational Dynamics and its optimization

This paper presents a workforce planning model scalable to an entire hierarchical organization. Its main objective is to design a cost optimal target which leverages flexible workforce solutions while ensuring an efficient promotional flux. The value of this paper lies in its proposal of an adequate flexibility rate using various solution types and in its discussion about external hiring ratios. The mathematical structures of the models are analyzed and numerical simulations illustrate the theoretical background.

math.AP

Distributed synaptic weights in a LIF neural network and learning rules

Leaky integrate-and-fire (LIF) models are mean-field limits, with a large number of neurons, used to describe neural networks. We consider inhomogeneous networks structured by a connec-tivity parameter (strengths of the synaptic weights) with the effect of processing the input current with different intensities. We first study the properties of the network activity depending on the distribution of synaptic weights and in particular its discrimination capacity. Then, we consider simple learning rules and determine the synaptic weight distribution it generates. We outline the role of noise as a selection principle and the capacity to memorized a learned signal.

q-bio.NC

Toward an integrated workforce planning framework using structured equations

Strategic Workforce Planning is a company process providing best in class, economically sound, workforce management policies and goals. Despite the abundance of literature on the subject, this is a notorious challenge in terms of implementation. Reasons span from the youth of the field itself to broader data integration concerns that arise from gathering information from financial, human resource and business excellence systems. This paper aims at setting the first stones to a simple yet robust quantitative framework for Strategic Workforce Planning exercises. First a method based on structured equations is detailed. It is then used to answer two main workforce related questions: how to optimally hire to keep labor costs flat? How to build an experience constrained workforce at a minimal cost?

q-fin.GN

On a voltage-conductance kinetic system for integrate and fire neural networks

The voltage-conductance kinetic equation for integrate and fire neurons has been used in neurosciences since a decade and describes the probability density of neurons in a network. It is used when slow conductance receptors are activated and noticeable applications to the visual cortex have been worked-out. In the simplest case, the derivation also uses the assumption of fully excitatory and moderately all-to-all coupled networks; this is the situation we consider here. We study properties of solutions of the kinetic equation for steady states and time evolution and we prove several global a priori bounds both on the probability density and the firing rate of the network. The main difficulties are related to the degeneracy of the diffusion resulting from noise and to the quadratic aspect of the nonlinearity. This result constitutes a paradox; the solutions of the kinetic model, of partially hyperbolic nature, are globally bounded but it has been proved that the fully parabolic integrate and fire equation (some kind of diffusion limit of the former) blows-up in finite time.

math.AP

Relaxation and self-sustained oscillations in the time elapsed neuron network model

The time elapsed model describes the firing activity of an homogeneous assembly of neurons thanks to the distribution of times elapsed since the last discharge. It gives a mathematical description of the probability density of neurons structured by this time. In an earlier work, based on generalized relative entropy methods, it is proved that for highly or weakly connected networks the model exhibits relaxation to the steady state and for moderately connected networks it is obtained numerical evidence of appearance of self-sustained periodic solutions. Here, we go further and, using the particular form of the model, we quantify the regime where relaxation to a stationary state occurs in terms of the network connectivity. To introduce our methodology, we first consider the case where the neurons are not connected and we give a new statement showing that total asynchronous firing of neurons appears asymptotically. In a second step, we consider the case with connections and give a low connectivity condition that still leads to asynchronous firing. Our low connectivity condition is somehow sharp because we can give an example, when this condition is not fulfilled, where synchronous rhythmic activity occurs. Indeed, we are able to build several explicit families of periodic solutions. Our construction is fully nonlinear and the resynchronization of the neural activity in the network does not follow from bifurcation analysis. It relies on an algebraically nonlinear boundary condition that occurs in the model.These analytic results are compared with numerical simulations under broader hypotheses and shown to be robust.

math.AP

A 2-adic approach of the human respiratory tree

We propose here a general framework to address the question of trace operators on a dyadic tree. This work is motivated by the modeling of the human bronchial tree which, thanks to its regularity, can be extrapolated in a natural way to an infinite resistive tree. The space of pressure fields at bifurcation nodes of this infinite tree can be endowed with a Sobolev space structure, with a semi-norm which measures the instantaneous rate of dissipated energy. We aim at describing the behaviour of finite energy pressure fields near the end. The core of the present approach is an identification of the set of ends with the ring Z_2 of 2-adic integers. Sobolev spaces over Z_2 can be defined in a very natural way by means of Fourier transform, which allows us to establish precised trace theorems which are formally quite similar to those in standard Sobolev spaces, with a Sobolev regularity which depends on the growth rate of resistances, i.e. on geometrical properties of the tree. Furthermore, we exhibit an explicit expression of the "ventilation operator", which maps pressure fields at the end of the tree onto fluxes, in the form of a convolution by a Riesz kernel based on the 2-adic distance.

math-ph