arXiv subjects

Dennis Shen

Publications and source records attributed to Dennis Shen.

15 recordsLinked to original sources

arXiv2026

From Control to Treatment: Causal Forecasting Beyond the Observed Panel

Conventional panel data methods recover retrospective counterfactuals within the observed horizon. Many policy decisions, however, are prospective: how would an untreated unit evolve beyond the observed panel under an intervention it has not previously experienced? We develop a causal forecasting framework that combines the counterfactual logic of synthetic controls with multivariate time-series extrapolation. Under a latent factor model, we impose low-rank structure on the treated-state time factors. This yields the Two-Way Synthetic Forecasting estimator, which learns cross-unit weights from pre-treatment outcomes and temporal dynamics from treated donors' post-treatment trajectories. We establish pointwise identification, finite-sample error bounds, consistency, asymptotic normality, and inference for prespecified linear summaries over fixed forecast horizons. Simulations support the theory, and an application to the opening of NFL stadiums during the 2020 season illustrates how the method can inform a prospective policy change using only information available at the decision date.

econ.EM↗

arXiv2024

Algebraic and Statistical Properties of the Partially Regularized Ordinary Least Squares Interpolator

Modern deep learning has revealed a surprising statistical phenomenon known as benign overfitting, with high-dimensional linear regression being a prominent example. This paper contributes to ongoing research on the ordinary least squares (OLS) interpolator, focusing on the partial regression setting, where only a subset of coefficients is implicitly regularized. On the algebraic front, we extend Cochran's formula and the leave-one-out residual formula for the partial regularization framework. On the stochastic front, we leverage our algebraic results to design several homoskedastic variance estimators under the Gauss-Markov model. These estimators serve as a basis for conducting statistical inference, albeit with slight conservatism in their performance. Through simulations, we study the finite-sample properties of these variance estimators across various generative models.

math.ST↗

arXiv2024

Synthetic Interventions

The synthetic controls (SC) methodology is a prominent tool for policy evaluation in panel data applications. Researchers commonly justify the SC framework with a low-rank matrix factor model that assumes the potential outcomes are described by low-dimensional unit and time specific latent factors. In the recent work of [Abadie '20], one of the pioneering authors of the SC method posed the question of how the SC framework can be extended to multiple treatments. This article offers one resolution to this open question that we call synthetic interventions (SI). Fundamental to the SI framework is a low-rank tensor factor model, which extends the matrix factor model by including a latent factorization over treatments. Under this model, we propose a generalization of the standard SC-based estimators. We prove the consistency for one instantiation of our approach and provide conditions under which it is asymptotically normal. Moreover, we conduct a representative simulation to study its prediction performance and revisit the canonical SC case study of [Abadie-Diamond-Hainmueller '10] on the impact of anti-tobacco legislations by exploring related questions not previously investigated.

econ.EM↗

arXiv2024

Personalized Predictions from Population Level Experiments: A Study on Alzheimer's Disease

The purpose of this article is to infer patient level outcomes from population level randomized control trials (RCTs). In this pursuit, we utilize the recently proposed synthetic nearest neighbors (SNN) estimator. At its core, SNN leverages information across patients to impute missing data associated with each patient of interest. We focus on two types of missing data: (i) unrecorded outcomes from discontinuing the assigned treatments and (ii) unobserved outcomes associated with unassigned treatments. Data imputation in the former powers and de-biases RCTs, while data imputation in the latter simulates "synthetic RCTs" to predict the outcomes for each patient under every treatment. The SNN estimator is interpretable, transparent, and causally justified under a broad class of missing data scenarios. Relative to several standard methods, we empirically find that SNN performs well for the above two applications using Phase 3 clinical trial data on patients with Alzheimer's Disease. Our findings directly suggest that SNN can tackle a current pain point within the clinical trial workflow on patient dropouts and serve as a new tool towards the development of precision medicine. Building on our insights, we discuss how SNN can further generalize to real-world applications.

stat.AP↗

arXiv2023

Benign overfitting beyond prediction: The ordinary least squares interpolator

Recent advances in deep learning have highlighted the phenomenon of benign overfitting in overparameterized statistical models, sparking significant interest in understanding its foundations. Owing to its simplicity and practical relevance, the ordinary least squares (OLS) interpolator has become a key object of study for gaining theoretical insight into this phenomenon. While the properties of OLS are well understood in classical underparameterized settings, its behavior in the overparameterized regime -- unlike that of ridge regression or the lasso -- remains comparatively less explored. We contribute to this growing literature by deriving new algebraic and statistical results for the minimum $\ell_2$-norm OLS interpolator. In contrast to much of the existing work, which focuses on prediction risk, we center our analysis on parameter estimation and inference, which are fundamental for many statistics and causal inference applications. Specifically, we establish overparameterized analogues of (i) the leave-$k$-out formulas, (ii) the omitted variable bias formula, and (iii) the Frisch-Waugh-Lovell theorem. Under the Gauss-Markov model, we further extend the Gauss-Markov theorem and analyze variance estimation under homoskedasticity in the overparameterized setting. Collectively, these results provide a systematic framework for studying parameter estimation and inference in overparameterized linear models, offering a novel perspective on benign overfitting beyond its implications for prediction.

math.ST↗

arXiv2023

On Model Identification and Out-of-Sample Prediction of Principal Component Regression: Applications to Synthetic Controls

We analyze principal component regression (PCR) in a high-dimensional error-in-variables setting with fixed design. Under suitable conditions, we show that PCR consistently identifies the unique model with minimum $\ell_2$-norm. These results enable us to establish non-asymptotic out-of-sample prediction guarantees that improve upon the best known rates. In the course of our analysis, we introduce a natural linear algebraic condition between the in- and out-of-sample covariates, which allows us to avoid distributional assumptions for out-of-sample predictions. Our simulations illustrate the importance of this condition for generalization, even under covariate shifts. Accordingly, we construct a hypothesis test to check when this conditions holds in practice. As a byproduct, our results also lead to novel results for the synthetic controls literature, a leading approach for policy evaluation. To the best of our knowledge, our prediction guarantees for the fixed design setting have been elusive in both the high-dimensional error-in-variables and synthetic controls literatures.

math.ST↗

arXiv2023

Causal Imputation via Synthetic Interventions

Consider the problem of determining the effect of a compound on a specific cell type. To answer this question, researchers traditionally need to run an experiment applying the drug of interest to that cell type. This approach is not scalable: given a large number of different actions (compounds) and a large number of different contexts (cell types), it is infeasible to run an experiment for every action-context pair. In such cases, one would ideally like to predict the outcome for every pair while only having to perform experiments on a small subset of pairs. This task, which we label "causal imputation", is a generalization of the causal transportability problem. To address this challenge, we extend the recently introduced synthetic interventions (SI) estimator to handle more general data sparsity patterns. We prove that, under a latent factor model, our estimator provides valid estimates for the causal imputation task. We motivate this model by establishing a connection to the linear structural causal model literature. Finally, we consider the prominent CMAP dataset in predicting the effects of compounds on gene expression across cell types. We find that our estimator outperforms standard baselines, thus confirming its utility in biological applications.

stat.ME↗

arXiv2022

Same Root Different Leaves: Time Series and Cross-Sectional Methods in Panel Data

A central goal in social science is to evaluate the causal effect of a policy. One dominant approach is through panel data analysis in which the behaviors of multiple units are observed over time. The information across time and space motivates two general approaches: (i) horizontal regression (i.e., unconfoundedness), which exploits time series patterns, and (ii) vertical regression (e.g., synthetic controls), which exploits cross-sectional patterns. Conventional wisdom states that the two approaches are fundamentally different. We establish this position to be partly false for estimation but generally true for inference. In particular, we prove that both approaches yield identical point estimates under several standard settings. For the same point estimate, however, each approach quantifies uncertainty with respect to a distinct estimand. In turn, the confidence interval developed for one estimand may have incorrect coverage for another. This emphasizes that the source of randomness that researchers assume has direct implications for the accuracy of inference.

econ.EM↗

arXiv2021

PerSim: Data-Efficient Offline Reinforcement Learning with Heterogeneous Agents via Personalized Simulators

We consider offline reinforcement learning (RL) with heterogeneous agents under severe data scarcity, i.e., we only observe a single historical trajectory for every agent under an unknown, potentially sub-optimal policy. We find that the performance of state-of-the-art offline and model-based RL methods degrade significantly given such limited data availability, even for commonly perceived "solved" benchmark settings such as "MountainCar" and "CartPole". To address this challenge, we propose PerSim, a model-based offline RL approach which first learns a personalized simulator for each agent by collectively using the historical trajectories across all agents, prior to learning a policy. We do so by positing that the transition dynamics across agents can be represented as a latent function of latent factors associated with agents, states, and actions; subsequently, we theoretically establish that this function is well-approximated by a "low-rank" decomposition of separable agent, state, and action latent functions. This representation suggests a simple, regularized neural network architecture to effectively learn the transition dynamics per agent, even with scarce, offline data. We perform extensive experiments across several benchmark environments and RL methods. The consistent improvement of our approach, measured in terms of both state dynamics prediction and eventual reward, confirms the efficacy of our framework in leveraging limited historical data to simultaneously learn personalized policies across agents.

cs.LG↗

arXiv2021

Causal Matrix Completion

Matrix completion is the study of recovering an underlying matrix from a sparse subset of noisy observations. Traditionally, it is assumed that the entries of the matrix are "missing completely at random" (MCAR), i.e., each entry is revealed at random, independent of everything else, with uniform probability. This is likely unrealistic due to the presence of "latent confounders", i.e., unobserved factors that determine both the entries of the underlying matrix and the missingness pattern in the observed matrix. For example, in the context of movie recommender systems -- a canonical application for matrix completion -- a user who vehemently dislikes horror films is unlikely to ever watch horror films. In general, these confounders yield "missing not at random" (MNAR) data, which can severely impact any inference procedure that does not correct for this bias. We develop a formal causal model for matrix completion through the language of potential outcomes, and provide novel identification arguments for a variety of causal estimands of interest. We design a procedure, which we call "synthetic nearest neighbors" (SNN), to estimate these causal estimands. We prove finite-sample consistency and asymptotic normality of our estimator. Our analysis also leads to new theoretical results for the matrix completion literature. In particular, we establish entry-wise, i.e., max-norm, finite-sample consistency and asymptotic normality results for matrix completion with MNAR data. As a special case, this also provides entry-wise bounds for matrix completion with MCAR data. Across simulated and real data, we demonstrate the efficacy of our proposed estimator.

econ.EM↗

arXiv2021

On Robustness of Principal Component Regression

Principal component regression (PCR) is a simple, but powerful and ubiquitously utilized method. Its effectiveness is well established when the covariates exhibit low-rank structure. However, its ability to handle settings with noisy, missing, and mixed-valued, i.e., discrete and continuous, covariates is not understood and remains an important open challenge. As the main contribution of this work we establish the robustness of PCR, without any change, in this respect and provide meaningful finite-sample analysis. To do so, we establish that PCR is equivalent to performing linear regression after pre-processing the covariate matrix via hard singular value thresholding (HSVT). As a result, in the context of counterfactual analysis using observational data, we show PCR is equivalent to the recently proposed robust variant of the synthetic control method, known as robust synthetic control (RSC). As an immediate consequence, we obtain finite-sample analysis of the RSC estimator that was previously absent. As an important contribution to the synthetic controls literature, we establish that an (approximate) linear synthetic control exists in the setting of a generalized factor model or latent variable model; traditionally in the literature, the existence of a synthetic control needs to be assumed to exist as an axiom. We further discuss a surprising implication of the robustness property of PCR with respect to noise, i.e., PCR can learn a good predictive model even if the covariates are tactfully transformed to preserve differential privacy. Finally, this work advances the state-of-the-art analysis for HSVT by establishing stronger guarantees with respect to the $\ell_{2, \infty}$-norm rather than the Frobenius norm as is commonly done in the matrix estimation literature, which may be of interest in its own right.

cs.LG↗

arXiv2020

Two Burning Questions on COVID-19: Did shutting down the economy help? Can we (partially) reopen the economy without risking the second wave?

As we reach the apex of the COVID-19 pandemic, the most pressing question facing us is: can we even partially reopen the economy without risking a second wave? We first need to understand if shutting down the economy helped. And if it did, is it possible to achieve similar gains in the war against the pandemic while partially opening up the economy? To do so, it is critical to understand the effects of the various interventions that can be put into place and their corresponding health and economic implications. Since many interventions exist, the key challenge facing policy makers is understanding the potential trade-offs between them, and choosing the particular set of interventions that works best for their circumstance. In this memo, we provide an overview of Synthetic Interventions (a natural generalization of Synthetic Control), a data-driven and statistically principled method to perform what-if scenario planning, i.e., for policy makers to understand the trade-offs between different interventions before having to actually enact them. In essence, the method leverages information from different interventions that have already been enacted across the world and fits it to a policy maker's setting of interest, e.g., to estimate the effect of mobility-restricting interventions on the U.S., we use daily death data from countries that enforced severe mobility restrictions to create a "synthetic low mobility U.S." and predict the counterfactual trajectory of the U.S. if it had indeed applied a similar intervention. Using Synthetic Interventions, we find that lifting severe mobility restrictions and only retaining moderate mobility restrictions (at retail and transit locations), seems to effectively flatten the curve. We hope this provides guidance on weighing the trade-offs between the safety of the population, strain on the healthcare system, and impact on the economy.

econ.EM↗

arXiv2019

mRSC: Multi-dimensional Robust Synthetic Control

When evaluating the impact of a policy on a metric of interest, it may not be possible to conduct a randomized control trial. In settings where only observational data is available, Synthetic Control (SC) methods provide a popular data-driven approach to estimate a "synthetic" control by combining measurements of "similar" units (donors). Recently, Robust SC (RSC) was proposed as a generalization of SC to overcome the challenges of missing data high levels of noise, while removing the reliance on domain knowledge for selecting donors. However, SC, RSC, and their variants, suffer from poor estimation when the pre-intervention period is too short. As the main contribution, we propose a generalization of unidimensional RSC to multi-dimensional RSC, mRSC. Our proposed mechanism incorporates multiple metrics to estimate a synthetic control, thus overcoming the challenge of poor inference from limited pre-intervention data. We show that the mRSC algorithm with $K$ metrics leads to a consistent estimator of the synthetic control for the target unit under any metric. Our finite-sample analysis suggests that the prediction error decays to zero at a rate faster than the RSC algorithm by a factor of $K$ and $\sqrt{K}$ for the training and testing periods (pre- and post-intervention), respectively. Additionally, we provide a diagnostic test that evaluates the utility of including additional metrics. Moreover, we introduce a mechanism to validate the performance of mRSC: time series prediction. That is, we propose a method to predict the future evolution of a time series based on limited data when the notion of time is relative and not absolute, i.e., we have access to a donor pool that has undergone the desired future evolution. Finally, we conduct experimentation to establish the efficacy of mRSC on synthetic data and two real-world case studies (retail and Cricket).

stat.ME↗

arXiv2019

Model Agnostic Time Series Analysis via Matrix Estimation

We propose an algorithm to impute and forecast a time series by transforming the observed time series into a matrix, utilizing matrix estimation to recover missing values and de-noise observed entries, and performing linear regression to make predictions. At the core of our analysis is a representation result, which states that for a large model class, the transformed time series matrix is (approximately) low-rank. In effect, this generalizes the widely used Singular Spectrum Analysis (SSA) in time series literature, and allows us to establish a rigorous link between time series analysis and matrix estimation. The key to establishing this link is constructing a Page matrix with non-overlapping entries rather than a Hankel matrix as is commonly done in the literature (e.g., SSA). This particular matrix structure allows us to provide finite sample analysis for imputation and prediction, and prove the asymptotic consistency of our method. Another salient feature of our algorithm is that it is model agnostic with respect to both the underlying time dynamics and the noise distribution in the observations. The noise agnostic property of our approach allows us to recover the latent states when only given access to noisy and partial observations a la a Hidden Markov Model; e.g., recovering the time-varying parameter of a Poisson process without knowing that the underlying process is Poisson. Furthermore, since our forecasting algorithm requires regression with noisy features, our approach suggests a matrix estimation based method - coupled with a novel, non-standard matrix estimation error metric - to solve the error-in-variable regression problem, which could be of interest in its own right. Through synthetic and real-world datasets, we demonstrate that our algorithm outperforms standard software packages (including R libraries) in the presence of missing data as well as high levels of noise.

cs.LG↗

arXiv2017

Robust Synthetic Control

We present a robust generalization of the synthetic control method for comparative case studies. Like the classical method, we present an algorithm to estimate the unobservable counterfactual of a treatment unit. A distinguishing feature of our algorithm is that of de-noising the data matrix via singular value thresholding, which renders our approach robust in multiple facets: it automatically identifies a good subset of donors, overcomes the challenges of missing data, and continues to work well in settings where covariate information may not be provided. To begin, we establish the condition under which the fundamental assumption in synthetic control-like approaches holds, i.e. when the linear relationship between the treatment unit and the donor pool prevails in both the pre- and post-intervention periods. We provide the first finite sample analysis for a broader class of models, the Latent Variable Model, in contrast to Factor Models previously considered in the literature. Further, we show that our de-noising procedure accurately imputes missing entries, producing a consistent estimator of the underlying signal matrix provided $p = Ω( T^{-1 + ζ})$ for some $ζ> 0$; here, $p$ is the fraction of observed data and $T$ is the time interval of interest. Under the same setting, we prove that the mean-squared-error (MSE) in our prediction estimation scales as $O(σ^2/p + 1/\sqrt{T})$, where $σ^2$ is the noise variance. Using a data aggregation method, we show that the MSE can be made as small as $O(T^{-1/2+γ})$ for any $γ\in (0, 1/2)$, leading to a consistent estimator. We also introduce a Bayesian framework to quantify the model uncertainty through posterior probabilities. Our experiments, using both real-world and synthetic datasets, demonstrate that our robust generalization yields an improvement over the classical synthetic control method.

econ.EM↗