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Dennis W. J. Klomp

Publications and source records attributed to Dennis W. J. Klomp.

2 recordsLinked to original sources

Design of a double breast gradient coil with controlled anterior posterior gradient variation for diffusion weighted imaging

Introduction High performance gradients poses a promise for breast diffusion weighted imaging (DWI) but are restricted by physiological limits in whole body scanners. While local nonlinear coils offer higher amplitudes, they often suffer from severe gradient reduction near the chest wall. Methods We introduced an optimization framework incorporating a constraint to control anterior posterior gradient variation. A width based figure of merit was defined to evaluate performance regarding coil efficiency and minimum wire width. A prototype was constructed to validate the design methodology. Results The optimized coil achieved a 2.35 fold efficiency increase over standard linear coils. Compared to previous nonlinear designs, the new constraint reduced spatial variation by 35.7% and improved minimum efficiency near the chest wall by 2.6 fold. Experimental field maps matched simulations with errors under 8%. Discussion The proposed method effectively mitigates the trade-off between gradient strength and spatial uniformity along anterior posterior direction. By enhancing performance in the posterior breast region, the design addresses a critical limitation of previous local coils. Conclusion This framework enables the development of high performance, robust local gradient coils, facilitating the clinical implementation of advanced DWI protocols for breast cancer screening.

physics.med-ph↗

Open-source Pulseq sequences on Philips MRI scanners

Purpose: This work aims to address the limitations faced by researchers in developing and sharing new MRI sequences by implementing an interpreter for the open-source MRI pulse sequence format, Pulseq, on a Philips MRI scanner. Methods: The implementation involved modifying a few source code files to create a Pulseq interpreter for the Philips MRI system. Validation experiments were conducted using simulations and phantom scans performed on a 7T Achieva MRI system. The observed sequence and waveforms were compared to the intended ones, and the gradient waveforms produced by the scanner were verified using a field camera. Image reconstruction was performed using the raw k-space samples acquired from both the native vendor environment and the Pulseq interpreter. Results: The reconstructed images obtained through the Pulseq implementation were found to be comparable to those obtained through the native implementation. The performance of the Pulseq interpreter was assessed by profiling the CPU utilization of the MRI spectrometer, showing minimal resource utilization for certain sequences. Conclusion: The successful implementation of the Pulseq interpreter on the Philips MRI scanner demonstrates the feasibility of utilizing Pulseq sequences on Philips MRI scanners. This provides an open-source platform for MRI sequence development, facilitating collaboration among researchers and accelerating scientific progress in the field of MRI.

physics.med-ph↗