arXiv subjects

Derrick Forchetti

Publications and source records attributed to Derrick Forchetti.

3 recordsLinked to original sources

arXiv2026

Decoding Future Risk: Deep Learning Analysis of Tubular Adenoma Whole-Slide Images

Colorectal cancer (CRC) remains a significant cause of cancer-related mortality, despite the widespread implementation of prophylactic initiatives aimed at detecting and removing precancerous polyps. Although screening effectively reduces incidence, a notable portion of patients initially diagnosed with low-grade adenomatous polyps will still develop CRC later in life, even without the presence of known high-risk syndromes. Identifying which low-risk patients are at higher risk of progression is a critical unmet need for tailored surveillance and preventative therapeutic strategies. Traditional histological assessment of adenomas, while fundamental, may not fully capture subtle architectural or cytological features indicative of malignant potential. Advancements in digital pathology and machine learning provide an opportunity to analyze whole-slide images (WSIs) comprehensively and objectively. This study investigates whether machine learning algorithms, specifically convolutional neural networks (CNNs), can detect subtle histological features in WSIs of low-grade tubular adenomas that are predictive of a patient's long-term risk of developing colorectal cancer.

cs.CV↗

arXiv2026

XtraLight-MedMamba for Classification of Neoplastic Tubular Adenomas

Accurate risk stratification of precancerous polyps during routine colonoscopy screening is a key strategy to reduce the incidence of colorectal cancer (CRC). However, assessment of low-grade dysplasia remains limited by subjective histopathologic interpretation. Advances in computational pathology and deep learning offer new opportunities to identify subtle, fine morphologic patterns associated with malignant progression that may be imperceptible to the human eye. In this work, we propose XtraLight-MedMamba, an ultra-lightweight state-space-based deep learning framework to classify neoplastic tubular adenomas from whole-slide images (WSIs). The architecture is a blend of a ConvNeXt-based shallow feature extractor with parallel vision mamba blocks to efficiently model local texture cues within global contextual structure. An integration of the Spatial and Channel Attention Bridge (SCAB) module enhances multiscale feature extraction, while the Fixed Non-Negative Orthogonal Classifier (FNOClassifier) enables substantial parameter reduction and improved generalization. The model was evaluated on a curated dataset acquired from patients with low-grade tubular adenomas, stratified into case and control cohorts based on subsequent CRC development. XtraLight-MedMamba achieved an accuracy of 97.18\% and an F1-score of 0.9767 using approximately 32,000 parameters, outperforming transformer-based and conventional Mamba architectures, which have significantly higher model complexity and computational burden, making it suitable for resource-constrained areas.

cs.CV↗

arXiv2025

UltraLight Med-Vision Mamba for Classification of Neoplastic Progression in Tubular Adenomas

Identification of precancerous polyps during routine colonoscopy screenings is vital for their excision, lowering the risk of developing colorectal cancer. Advanced deep learning algorithms enable precise adenoma classification and stratification, improving risk assessment accuracy and enabling personalized surveillance protocols that optimize patient outcomes. Ultralight Med-Vision Mamba, a state-space based model (SSM), has excelled in modeling long- and short-range dependencies and image generalization, critical factors for analyzing whole slide images. Furthermore, Ultralight Med-Vision Mamba's efficient architecture offers advantages in both computational speed and scalability, making it a promising tool for real-time clinical deployment.

cs.CV↗