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Didier Concordet

Publications and source records attributed to Didier Concordet.

6 recordsLinked to original sources

Nonstandard likelihood-ratio limits under semidefinite rank constraints

We study likelihood-ratio tests for the hypothesis that a positive-semidefinite matrix has rank at most a prescribed value. The null hypothesis is stratified: points of maximal allowed rank lie on a regular boundary stratum, whereas lower-rank points are singular. Consequently, the usual chi-bar-square calibration on the top stratum does not by itself describe the whole composite null, especially along sequences whose rank changes at the local $n^{-1/2}$ scale. After profiling regular nuisance parameters, we derive a common reduced Gaussian experiment for every fixed null rank and for all admissible local rank transitions. On the top stratum, the classical chi-bar-square law is recovered. At lower ranks, the limit generally involves projection onto a nonconvex rank-constrained semidefinite set. Our main calibration result shows that, under isotropy, the top-stratum law is least favourable over all fixed null strata and all local null rank transitions. We also prove the corresponding transition dominance under arbitrary anisotropy when the active corank is one. Finally, on the top stratum, we obtain a conditional shape derivative for the limiting distribution and its critical value. Gaussian covariance models and finite-sample experiments illustrate nuisance profiling, rank transitions, anisotropy, and orientation sensitivity.

math.ST

Delivery strategies to improve piglets exposure to oral antibiotics

The widespread practice of delivering antibiotics through drinking water to livestock leads to considerable variability in exposure levels among animals, raising concerns regarding disease outbreaks and the emergence of antibiotic resistance. This variability is primarily driven by three pivotal factors: fluctuations in drug concentration within water pipes, variances in drinking behavior among animals, and differences in individual pharmacokinetic parameters. This article introduces an approach aimed at improving medication distribution by customizing it according to the drinking patterns of pigs, without escalating the medication dose. As examples, we demonstrate that incorporating the drinking behavior into the delivery of amoxicillin results in an increase in the percentage of piglets reaching an AUC/MIC ratio greater than 25h. Specifically, with Pasteurella multocida, the percentage rises from 30% to at least 60%, while with Actinobacillus pleuropneumoniae, it increases from 20% to more than 70%.

q-bio.QM

Confidence regions for the multinomial parameter with small sample size

Consider the observation of n iid realizations of an experiment with d>1 possible outcomes, which corresponds to a single observation of a multinomial distribution M(n,p) where p is an unknown discrete distribution on {1,...,d}. In many applications, the construction of a confidence region for p when n is small is crucial. This concrete challenging problem has a long history. It is well known that the confidence regions built from asymptotic statistics do not have good coverage when n is small. On the other hand, most available methods providing non-asymptotic regions with controlled coverage are limited to the binomial case d=2. In the present work, we propose a new method valid for any d>1. This method provides confidence regions with controlled coverage and small volume, and consists of the inversion of the "covering collection"' associated with level-sets of the likelihood. The behavior when d/n tends to infinity remains an interesting open problem beyond the scope of this work.

stat.CO

A new method for the estimation of variance matrix with prescribed zeros in nonlinear mixed effects models

We propose a new method for the Maximum Likelihood Estimator (MLE) of nonlinear mixed effects models when the variance matrix of Gaussian random effects has a prescribed pattern of zeros (PPZ). The method consists in coupling the recently developed Iterative Conditional Fitting (ICF) algorithm with the Expectation Maximization (EM) algorithm. It provides positive definite estimates for any sample size, and does not rely on any structural assumption on the PPZ. It can be easily adapted to many versions of EM.

stat.ME

Explicit formulas for a continuous stochastic maturation model. Application to anticancer drug pharmacokinetics/pharmacodynamics

We present a continuous time model of maturation and survival, obtained as the limit of a compartmental evolution model when the number of compartments tends to infinity. We establish in particular an explicit formula for the law of the system output under inhomogeneous killing and when the input follows a time-inhomogeneous Poisson process. This approach allows the discussion of identifiability issues which are of difficult access for finite compartmental models. The article ends up with an example of application for anticancer drug pharmacokinetics/pharmacodynamics.

math.PR

On the strong consistency of asymptotic M-estimators

The aim of this article is to simplify Pfanzagl's proof of consistency for asymptotic maximum likelihood estimators, and to extend it to more general asymptotic M-estimators. The method relies on the existence of a sort of contraction of the parameter space which admits the true parameter as a fixed point. The proofs are short and elementary.

math.ST