arXiv subjects

Dinh-Tuan Phan

Publications and source records attributed to Dinh-Tuan Phan.

3 recordsLinked to original sources

arXiv2021

Integrative Wireless Device for Remote Continuous Blood Biomarker Monitoring

To perform precision medicine in realtime at home, a device capable of long distance continuously monitoring target biomolecules in unprocessed blood under dynamic situations is essential. In this study, an integrative buffer free wireless device is developed to measure drug concentrations in patients blood in real time for remote clinical healthcare. To demonstrate its capability, the drug molecules (i.e., small molecule drug doxorubicin, DOX) are continuously measured in the unprocessed whole blood of live animals (e.g., rats). The dynamic changes of drug concentrations with sub minute temporal resolution are recorded for an extended period of time (8 hours). As an advance in remote diagnosis, this device would benefit the public by enabling long-distance precision medicine to prevent pandemics in advance.

physics.med-ph↗

arXiv2020

Vibration-induced actuation of droplets on microstructured surfaces

When a liquid droplet impacts a vibrated micro-structured surface with asymmetric topology, the liquids perform a horizontal motion during its bouncing. The moving effect is observed when the liquid is in contact with a low surface energy surface (e.g. hydrophobic) and over a wide amplitude and frequency range. We propose that the motion direction of liquid droplets is driven by a force exerted by the unbalanced vapor flow between the contact of solid and the liquid due to the asymmetric geometry. We observe the levitation and movement dynamics of the droplet impacting on a vibrated micro-structured surface to reveal the processes responsible for the transitional regime between the moving, unmoved, and broken droplet as the vibration amplitude and frequency increases. Based on the insight provided by the experiment and on the analysis of the kinetic energy of the droplet, we develop a quantitative model for the dynamic movement and its dependence on the vibration characteristics.

physics.flu-dyn↗

arXiv2020

High Throughput Separation of Cells Achieved Through the Particle Characteristic Dielectrophoretic Response and Further Focusing

Previous devices to separate cells by the characteristic force they experience due to dielectrophoresis, which depends on the size and electric properties of the particle, were limited by the flow rates and particle concentrations separation could be achieved at. To unlock the potential of Lab-on-a-chip technology to create flexible, efficient and multifunction devices at low cost it is necessary to increase the rates at which separations can be performed. Here we present a device capable of high throughput continuous separation of cells from microparticles and demonstrate separation at 7 uL/min in a microchannel with a high density of cells and microparticles in the sample of 10^8-10^9 cells/mL. This device uses the characteristic response of the particles due to dielectrophoresis to provide the initial separation before crucially focusing the particles into completely separate particle streams allowing the operation at high flow rates and particle concentrations. The device is demonstrated with the separation of polystyrene (PS) beads 8 microns, 25 microns and human dermal microvascular endothelial cell line (HMEC-1 cells) and human liver cell line (HepG2 cells) suspended in a DEP buffer solution. We show that it is possible to achieve not only high flow rate separation but also high sample purity with, after separation and focusing, one output containing 100% cells.

physics.app-ph↗