arXiv subjects

Divine Wanduku

Publications and source records attributed to Divine Wanduku.

7 recordsLinked to original sources

arXiv2019

Some asymptotic properties of SEIRS models with nonlinear incidence and random delays

TThis paper presents the dynamics of mosquitoes and humans, with general nonlinear incidence rate and multiple distributed delays for the disease. The model is a SEIRS system of delay differential equations. The normalized dimensionless version is derived; analytical techniques are applied to find conditions for deterministic extinction and permanence of disease. The BRN $R^{*}_{0}$ and ESPR $E(e^{-(μ_{v}T_{1}+μT_{2})})$ are computed. Conditions for deterministic extinction and permanence are expressed in terms of $R^{*}_{0}$ and $E(e^{-(μ_{v}T_{1}+μT_{2})})$, and applied to a P.vivax malaria scenario. Numerical results are given.

math.DS↗

arXiv2019

Complete maximum likelihood estimation for SEIR epidemic models: theoretical development

We present a class of SEIR Markov chain models for infectious diseases observed over discrete time in a random human population living in a closed environment. The population changes over time through random births, deaths, and transitions between states of the population. The SEIR models consist of random dynamical equations for each state (S, E, I and R) involving driving events for the process. We characterize some special types of SEIR Markov chain models in the class including: (1) when birth and death are zero or non-zero, and (2) when the incubation and infectious periods are constant or random. A detailed parameter estimation applying the maximum likelihood estimation technique and expectation maximization algorithm are presented for this study. Numerical simulation results are given to validate the epidemic models.

q-bio.PE↗

arXiv2019

On a family of stochastic SVIR influenza epidemic models and maximum likelihood estimation

This study presents a family of stochastic models for the dynamics of influenza in a closed human population. We consider treatment for the disease in the form of vaccination, and incorporate the periods of effectiveness of the vaccine and infectiousness for the individuals in the population. Our model is a SVIR model, with trinomial transition probabilities, where all individuals who recover from the disease acquire permanent natural immunity against the strain of the disease. Special SVIR models in the family are presented, based on the structure of the probability of getting infection and vaccination at any instant. The methods of maximum likelihood, and expectation maximization are derived for the parameters of the chain. Moreover, estimators for some epidemiological assessment parameters, such as the basic reproduction number are computed. Numerical simulation examples are presented for the model.

q-bio.PE↗

arXiv2019

The stochastic extinction and stability conditions for a class of malaria epidemic models

The stochastic extinction and stability in the mean of a family of SEIRS malaria models with a general nonlinear incidence rate is presented. The dynamics is driven by independent white noise processes from the disease transmission and natural death rates. The basic reproduction number $R^{*}_{0}$, the expected survival probability of the plasmodium $E(e^{-(μ_{v}T_{1}+μT_{2})})$, and other threshold values are calculated. A sample Lyapunov exponential analysis for the system is utilized to obtain extinction results. Moreover, the rate of extinction of malaria is estimated, and innovative local Martingale and Lyapunov functional techniques are applied to establish the strong persistence, and asymptotic stability in the mean of the malaria-free steady population. %The extinction of malaria depends on $R^{*}_{0}$, and $E(e^{-(μ_{v}T_{1}+μT_{2})})$. Moreover, for either $R^{*}_{0}<1$, or $E(e^{-(μ_{v}T_{1}+μT_{2})})<\frac{1}{R^{*}_{0}}$, whenever $R^{*}_{0}\geq 1$, respectively, extinction of malaria occurs. Furthermore, the robustness of these threshold conditions to the intensity of noise from the disease transmission rate is exhibited. Numerical simulation results are presented.

q-bio.PE↗

arXiv2018

A comparative stochastic and deterministic study of a class of epidemic dynamic models for malaria: exploring the impacts of noise on eradication and persistence of disease

A comparative stochastic and deterministic study of a family of SEIRS epidemic dynamic models for malaria is presented. The family type is determined by the qualitative behavior of the nonlinear incidence rates of the disease. Furthermore, the malaria models exhibit three random delays:- two of the delays represent the incubation periods of the disease inside the vector and human hosts, whereas the third delay is the period of effective natural immunity against the disease. The stochastic malaria models are improved by including the random environmental fluctuations in the disease transmission and natural death rates of humans. Insights about the effects of the delays and the noises on the malaria dynamics are gained via comparative analyses of the family of stochastic and deterministic models, and further critical examination of the significance of the intensities of the white noises in the system on (1) the existence and stability of the equilibria, and also on (2) the eradication and persistence of malaria in the human population. The basic reproduction numbers and other threshold values for malaria in the stochastic and deterministic settings are determined and compared for the cases of constant or random delays in the system. Numerical simulation results are presented.

q-bio.PE↗

arXiv2018

The stochastic permanence of malaria, and the existence of a stationary distribution for a class of malaria models

This paper investigates the stochastic permanence of malaria and the existence of a stationary distribution for the stochastic process describing the disease dynamics over sufficiently longtime. The malaria system is highly random with fluctuations from the disease transmission and natural deathrates, which are expressed as independent white noise processes in a family of stochastic differential equation epidemic models. Other sources of variability in the malaria dynamics are the random incubation and naturally acquired immunity periods of malaria. Improved analytical techniques and local martingale characterizations are applied to describe the character of the sample paths of the solution process of the system in the neighborhood of an endemic equilibrium. Emphasis of this study is laid on examination of the impacts of (1) the sources of variability- disease transmission and natural death rates, and (2) the intensities of the white noise processes in the system on the stochastic permanence of malaria, and also on the existence of the stationary distribution for the solution process over sufficiently long time. Numerical simulation examples are presented to illuminate the persistence and stochastic permanence of malaria, and also to numerically approximate the stationary distribution of the states of the solution process.

q-bio.PE↗

arXiv2018

Analyzing the qualitative properties of white noise on a family of infectious disease models in a highly random environment

A class of stochastic vector-borne infectious disease models is derived and studied. The class type is determined by a general nonlinear incidence rate of the disease. The disease spreads in a highly random environment with variability from the disease transmission and natural death rates. Other sources of variability include the random delays of disease incubation inside the vector and the human being, and also the random delay due to the period of effective acquired immunity against the disease. The basic reproduction number and other threshold conditions for disease eradication are computed. The qualitative behaviors of the disease dynamics are examined under the different sources of variability in the system. A technique to classify the different levels of the intensities of the noises in the system is presented, and used to investigate the qualitative behaviors of the disease dynamics in the infection-free steady state population under the different intensity levels of the white noises in the system. Moreover, the possibility of population extinction, whenever the intensities of the white noises in the system are high is examined. Numerical simulation results are presented to elucidate the theoretical results.

q-bio.PE↗