Dominic Jurkschat | Searcharxiv

arXiv2026

Phase-contrast micro-CT for intra-operative breast tumour margin assessment using a microfocus x-ray source and photon-counting detector

Objective: Intra-operative tumour margin assessment during breast-conserving surgery requires rapid, high-resolution imaging of excised tissue, allowing the surgical team to take appropriate action within a single operation. This study evaluates a custom propagation-based phase-contrast micro-computed tomography (micro-CT) system designed to meet these clinical constraints without specialised optical elements. Methods: The experimental setup pairs a microfocus x-ray source with a photon-counting detector in a cone-beam geometry. We explore how the spatial coherence of the source can provide propagation-based phase contrast -- with no additional specialised optical elements -- and balance this against maximising the x-ray flux of the cone-beam geometry. System performance was evaluated across two anode target materials and filtration configurations at various tube power settings. Imaging capabilities were validated using anthropomorphic breast tissue phantoms and a formalin-fixed paraffin-embedded (FFPE) breast tissue specimen, with reconstructions compared against gold-standard histology. Results: An unfiltered tungsten target operated at 40 kVp yielded optimal image quality. The optimised system achieved high-resolution CT reconstructions of a 5 cm diameter sample with an isotropic voxel size of 40.7 $\upmu\text{m}$ in a scan time of 12 minutes. Reconstructed volumes demonstrated strong visual correlation with corresponding histology slides. Conclusion: Combining a microfocus source with a photon-counting detector enables high-resolution, phase-contrast micro-CT within a clinically viable timeframe, demonstrating strong potential for intra-operative margin assessment.

physics.med-ph↗

arXiv2021

Quantum chicken-egg dilemmas: Delayed-choice causal order and the reality of causal non-separability

Recent frameworks describing quantum mechanics in the absence of a global causal order admit the existence of causally indefinite processes, where it is impossible to ascribe causal order for events A and B. These frameworks even allow for processes that violate the so-called causal inequalities, which are analogous to Bell's inequalities. However, the physicality of these exotic processes is, in the general case, still under debate, bringing into question their foundational relevance. While it is known that causally indefinite processes can be probabilistically realised by means of a quantum circuit, along with an additional conditioning event C, concrete insights into the ontological meaning of such implementation schemes have heretofore been limited. Here, we show that causally indefinite processes can be realised with schemes where C serves only as a classical flag heralding which causally indefinite process was realised. We then show that there are processes where any pure conditioning measurement of C leads to a causally indefinite process for A and B, thus establishing causal indefiniteness as a basis-independent quantity. Finally, we demonstrate that quantum mechanics allows for phenomena where C can deterministically decide whether A comes before B or vice versa, without signalling to either. This is akin to Wheeler's famous delayed-choice experiment establishing definite causal order in quantum mechanics as instrument-\textit{dependent} property.

quant-ph↗