arXiv subjects

Dominic Marshall

Publications and source records attributed to Dominic Marshall.

4 recordsLinked to original sources

arXiv2025

Benchmarking CXR Foundation Models With Publicly Available MIMIC-CXR and NIH-CXR14 Datasets

Recent foundation models have demonstrated strong performance in medical image representation learning, yet their comparative behaviour across datasets remains underexplored. This work benchmarks two large-scale chest X-ray (CXR) embedding models (CXR-Foundation (ELIXR v2.0) and MedImagelnsight) on public MIMIC-CR and NIH ChestX-ray14 datasets. Each model was evaluated using a unified preprocessing pipeline and fixed downstream classifiers to ensure reproducible comparison. We extracted embeddings directly from pre-trained encoders, trained lightweight LightGBM classifiers on multiple disease labels, and reported mean AUROC, and F1-score with 95% confidence intervals. MedImageInsight achieved slightly higher performance across most tasks, while CXR-Foundation exhibited strong cross-dataset stability. Unsupervised clustering of MedImageIn-sight embeddings further revealed a coherent disease-specific structure consistent with quantitative results. The results highlight the need for standardised evaluation of medical foundation models and establish reproducible baselines for future multimodal and clinical integration studies.

cs.CV↗

arXiv2025

Improving ARDS Diagnosis Through Context-Aware Concept Bottleneck Models

Large, publicly available clinical datasets have emerged as a novel resource for understanding disease heterogeneity and to explore personalization of therapy. These datasets are derived from data not originally collected for research purposes and, as a result, are often incomplete and lack critical labels. Many AI tools have been developed to retrospectively label these datasets, such as by performing disease classification; however, they often suffer from limited interpretability. Previous work has attempted to explain predictions using Concept Bottleneck Models (CBMs), which learn interpretable concepts that map to higher-level clinical ideas, facilitating human evaluation. However, these models often experience performance limitations when the concepts fail to adequately explain or characterize the task. We use the identification of Acute Respiratory Distress Syndrome (ARDS) as a challenging test case to demonstrate the value of incorporating contextual information from clinical notes to improve CBM performance. Our approach leverages a Large Language Model (LLM) to process clinical notes and generate additional concepts, resulting in a 10% performance gain over existing methods. Additionally, it facilitates the learning of more comprehensive concepts, thereby reducing the risk of information leakage and reliance on spurious shortcuts, thus improving the characterization of ARDS.

cs.LG↗

arXiv2025

Unpaired Translation of Chest X-ray Images for Lung Opacity Diagnosis via Adaptive Activation Masks and Cross-Domain Alignment

Chest X-ray radiographs (CXRs) play a pivotal role in diagnosing and monitoring cardiopulmonary diseases. However, lung opacities in CXRs frequently obscure anatomical structures, impeding clear identification of lung borders and complicating the localization of pathology. This challenge significantly hampers segmentation accuracy and precise lesion identification, which are crucial for diagnosis. To tackle these issues, our study proposes an unpaired CXR translation framework that converts CXRs with lung opacities into counterparts without lung opacities while preserving semantic features. Central to our approach is the use of adaptive activation masks to selectively modify opacity regions in lung CXRs. Cross-domain alignment ensures translated CXRs without opacity issues align with feature maps and prediction labels from a pre-trained CXR lesion classifier, facilitating the interpretability of the translation process. We validate our method using RSNA, MIMIC-CXR-JPG and JSRT datasets, demonstrating superior translation quality through lower Frechet Inception Distance (FID) and Kernel Inception Distance (KID) scores compared to existing methods (FID: 67.18 vs. 210.4, KID: 0.01604 vs. 0.225). Evaluation on RSNA opacity, MIMIC acute respiratory distress syndrome (ARDS) patient CXRs and JSRT CXRs show our method enhances segmentation accuracy of lung borders and improves lesion classification, further underscoring its potential in clinical settings (RSNA: mIoU: 76.58% vs. 62.58%, Sensitivity: 85.58% vs. 77.03%; MIMIC ARDS: mIoU: 86.20% vs. 72.07%, Sensitivity: 92.68% vs. 86.85%; JSRT: mIoU: 91.08% vs. 85.6%, Sensitivity: 97.62% vs. 95.04%). Our approach advances CXR imaging analysis, especially in investigating segmentation impacts through image translation techniques.

eess.IV↗

arXiv2024

Anatomy-Guided Radiology Report Generation with Pathology-Aware Regional Prompts

Radiology reporting generative AI holds significant potential to alleviate clinical workloads and streamline medical care. However, achieving high clinical accuracy is challenging, as radiological images often feature subtle lesions and intricate structures. Existing systems often fall short, largely due to their reliance on fixed size, patch-level image features and insufficient incorporation of pathological information. This can result in the neglect of such subtle patterns and inconsistent descriptions of crucial pathologies. To address these challenges, we propose an innovative approach that leverages pathology-aware regional prompts to explicitly integrate anatomical and pathological information of various scales, significantly enhancing the precision and clinical relevance of generated reports. We develop an anatomical region detector that extracts features from distinct anatomical areas, coupled with a novel multi-label lesion detector that identifies global pathologies. Our approach emulates the diagnostic process of radiologists, producing clinically accurate reports with comprehensive diagnostic capabilities. Experimental results show that our model outperforms previous state-of-the-art methods on most natural language generation and clinical efficacy metrics, with formal expert evaluations affirming its potential to enhance radiology practice.

cs.CV↗