arXiv subjects

Dong Xiao

Publications and source records attributed to Dong Xiao.

23 records · Page 2Linked to original sources

arXiv2022

Compact and Robust Deep Learning Architecture for Fluorescence Lifetime Imaging and FPGA Implementation

This paper reported a bespoke adder-based deep learning network for time-domain fluorescence lifetime imaging (FLIM). By leveraging the l1-norm extraction method, we propose a 1-D Fluorescence Lifetime AdderNet (FLAN) without multiplication-based convolutions to reduce the computational complexity. Further, we compressed fluorescence decays in temporal dimension using a log-scale merging technique to discard redundant temporal information derived as log-scaling FLAN (FLAN+LS). FLAN+LS achieves 0.11 and 0.23 compression ratios compared with FLAN and a conventional 1-D convolutional neural network (1-D CNN) while maintaining high accuracy in retrieving lifetimes. We extensively evaluated FLAN and FLAN+LS using synthetic and real data. A traditional fitting method and other non-fitting, high-accuracy algorithms were compared with our networks for synthetic data. Our networks attained a minor reconstruction error in different photon-count scenarios. For real data, we used fluorescent beads' data acquired by a confocal microscope to validate the effectiveness of real fluorophores, and our networks can differentiate beads with different lifetimes. Additionally, we implemented the network architecture on a field-programmable gate array (FPGA) with a post-quantization technique to shorten the bit-width, thereby improving computing efficiency. FLAN+LS on hardware achieves the highest computing efficiency compared to 1-D CNN and FLAN. We also discussed the applicability of our network and hardware architecture for other time-resolved biomedical applications using photon-efficient, time-resolved sensors.

eess.SP↗

arXiv2022

Fast fluorescence lifetime imaging analysis via extreme learning machine

We present a fast and accurate analytical method for fluorescence lifetime imaging microscopy (FLIM) using the extreme learning machine (ELM). We used extensive metrics to evaluate ELM and existing algorithms. First, we compared these algorithms using synthetic datasets. Results indicate that ELM can obtain higher fidelity, even in low-photon conditions. Afterwards, we used ELM to retrieve lifetime components from human prostate cancer cells loaded with gold nanosensors, showing that ELM also outperforms the iterative fitting and non-fitting algorithms. By comparing ELM with a computational efficient neural network, ELM achieves comparable accuracy with less training and inference time. As there is no back-propagation process for ELM during the training phase, the training speed is much higher than existing neural network approaches. The proposed strategy is promising for edge computing with online training.

physics.bio-ph↗

arXiv2022

Learning Modified Indicator Functions for Surface Reconstruction

Surface reconstruction is a fundamental problem in 3D graphics. In this paper, we propose a learning-based approach for implicit surface reconstruction from raw point clouds without normals. Our method is inspired by Gauss Lemma in potential energy theory, which gives an explicit integral formula for the indicator functions. We design a novel deep neural network to perform surface integral and learn the modified indicator functions from un-oriented and noisy point clouds. We concatenate features with different scales for accurate point-wise contributions to the integral. Moreover, we propose a novel Surface Element Feature Extractor to learn local shape properties. Experiments show that our method generates smooth surfaces with high normal consistency from point clouds with different noise scales and achieves state-of-the-art reconstruction performance compared with current data-driven and non-data-driven approaches.

cs.CV↗

arXiv2021

Effect of near-field distribution on transmission characteristics of fiber-fed Fabry-Perot etalons

Fiber-fed etalons are widely employed in advanced interferometric instruments such as gravitational-wave detectors, ultrastable lasers and calibration reference for high-precision spectrographs. We demonstrate that variation in near-field distribution of the feeding fiber would deteriorate the spectrum precision of the fiber-fed Fabry-Perot etalon, especially when precision at the order of 3 * 10-10 or higher is required. The octagonal fiber reinforced with double scrambler could greatly improve the steadiness and uniformness of the near-field distribution. When building wavelength calibrators for sub-m s-1 precision radial-velocity instruments, the double scrambler should be considered meticulously.

astro-ph.IM↗

arXiv2020

The backbone-residual model. Accurately characterising the instrumental profile of a fibre-fed echelle spectrograph

Context: Instrumental profile (IP) is the basic property of a spectrograph. Accurate IP characterisation is the prerequisite of accurate wavelength solution. It also facilitates new spectral acquisition methods such as the forward modeling and deconvolution. Aims: We investigate an IP modeling method for the fibre-fed echelle spectrograph with the emission lines of the ThAr lamp, and explore the method to evaluate the accuracy of IP characterisation. Methods: The backbone-residual (BR) model is put forward and tested on the fibre-fed High Resolution Spectrograph (HRS) at the Chinese Xinglong 2.16-m Telescope, which is the sum of the backbone function and the residual function. The backbone function is a bell-shaped function to describe the main component and the spatial variation of IP. The residual function, which is expressed as the cubic spline function, accounts for the difference between the bell-shaped function and the actual IP. The method of evaluating the accuracy of IP characterisation is based on the spectral reconstruction and Monte Carlo simulation. Results: The IP of HRS is characterised with the BR model, and the accuracy of the characterised IP reaches 0.006 of the peak value of the backbone function. This result demonstrates that the accurate IP characterisation has been achieved on HRS with the BR model, and the BR model is an excellent choice for accurate IP characterisation of fibre-fed echelle spectrographs.

astro-ph.IM↗