arXiv subjects

Dongwoon Hyun

Publications and source records attributed to Dongwoon Hyun.

4 recordsLinked to original sources

arXiv2026

A Wavefield Correlation Approach to Improve Sound Speed Estimation in Ultrasound Autofocusing

In pulse-echo ultrasound, aberration often degrades image quality when beamforming does not account for wavefront distortions. To address this issue, local sound speed estimators have been developed in the past decade for distributed aberration correction. Recently, methods based on iterative optimization have improved sound speed accuracy with respect to earlier approaches. However, the accuracy of these newer methods is limited by media with reverberation clutter and by the straight-ray model of wave propagation. To address these challenges, we propose using wavefield correlation (WFC) beamforming when performing sound speed optimization. WFC, an ultrasound adaptation of reverse time migration, correlates simulated forward-propagated transmit wavefields and backwards-propagated receive wavefields in order to reconstruct images. This process more accurately models wave propagation in heterogeneous media and can decrease diffuse clutter due to its spatiotemporal matched filtering effect. We implement herein a WFC beamformer using an auto-differentiation software and estimate the sound speed map by optimizing a regularized common-midpoint phase focusing criterion using gradient descent. This approach is compared to a previous method relying on delay and sum (DAS) with straight-ray time delay calculations on a variety of simulated, phantom, and in vivo data with large sound speed variations and clutter. Results show that using WFC decreases sound speed estimation error, leading to improvements in resolution and contrast in the corrected image. In particular, these promising results have potential to improve pulse-echo imaging for challenging clinical scenarios.

physics.med-ph↗

arXiv2026

The Contrast Order: An Order-Based Image Quality Criterion for Nonlinear Beamformers

Many modern ultrasound beamformers report improved image quality when evaluated using classical criteria like the contrast ratio and contrast-to-noise ratio, which are based on summary statistics of regions of interest (ROIs). However, nonlinear beamformers and post-processing methods can substantially alter these statistics, raising concerns that the reported improvements may reflect changes in dynamic range or remapping rather than a reflection of true information gain, such as clutter suppression. New criteria like the generalized contrast-to-noise ratio (gCNR) address these concerns, but rely on noisy estimates of the underlying distribution. To address this, we introduce a new image quality criterion, called the contrast order (CO), defined as the expected value of the sign of the difference in brightness between two ROIs. The CO is invariant under all strictly monotonic transformations of the image values, as it depends only on their relative ordering, and is interpretable as the probability that one ROI is brighter than the other minus the probability that it is darker. Unlike the gCNR, the CO has a simple unbiased estimator whose variance decreases with the number of samples in each ROI. We further propose the effective contrast ratio (ECR), which calibrates the contrast order to the familiar contrast ratio such that the two coincide under ideal Rayleigh-speckle statistics. Together, the CO and ECR provide order- and sign-preserving, dynamic-range-invariant criteria for evaluating lesion contrast, offering a principled alternative to classical and newer image quality criteria when assessing modern beamformers.

physics.med-ph↗

arXiv2025

Ultrasound Autofocusing: Common Midpoint Phase Error Optimization via Differentiable Beamforming

In ultrasound imaging, propagation of an acoustic wavefront through heterogeneous media causes phase aberrations that degrade the coherence of the reflected wavefront, leading to reduced image resolution and contrast. Adaptive imaging techniques attempt to correct this phase aberration and restore coherence, leading to improved focusing of the image. We propose an autofocusing paradigm for aberration correction in ultrasound imaging by fitting an acoustic velocity field to pressure measurements, via optimization of the common midpoint phase error (CMPE), using a straight-ray wave propagation model for beamforming in diffusely scattering media. We show that CMPE induced by heterogeneous acoustic velocity is a robust measure of phase aberration that can be used for acoustic autofocusing. CMPE is optimized iteratively using a differentiable beamforming approach to simultaneously improve the image focus while estimating the acoustic velocity field of the interrogated medium. The approach relies solely on wavefield measurements using a straight-ray integral solution of the two-way time-of-flight without explicit numerical time-stepping models of wave propagation. We demonstrate method performance through in silico simulations, in vitro phantom measurements, and in vivo mammalian models, showing practical applications in distributed aberration quantification, correction, and velocity estimation for medical ultrasound autofocusing.

physics.med-ph↗

arXiv2025

Enhancing Ultrasound Molecular Imaging: Toward Real-Time RPCA-Based Filtering to Differentiate Bound and Free Microbubbles

Ultrasound molecular imaging (UMI) is an advanced imaging modality that shows promise in detecting cancer at early stages. It uses microbubbles as contrast agents, which are functionalized to bind to cancer biomarkers overexpressed on endothelial cells. A major challenge in UMI is isolating bound microbubble signal, which represents the molecular imaging signal, from that of free-floating microbubbles, which is considered background noise. In this work, we propose a fast GPU-based method using robust principal component analysis (RPCA) to distinguish bound microbubbles from free-floating ones. We explore the method using simulations and measure the accuracy using the Dice coefficient and RMS error as functions of the number of frames used in RPCA reconstruction. Experiments using stationary and flowing microbubbles in tissue-mimicking phantoms were used to validate the method. Additionally, the method was applied to data from ten transgenic mouse models of breast cancer development, injected with B7-H3-targeted microbubbles, and two mice injected with non-targeted microbubbles. The results showed that RPCA using 20 frames achieved a Dice score of 0.95 and a computation time of 0.2 seconds, indicating that 20 frames is potentially suitable for real-time implementation. On in vivo data, RPCA using 20 frames achieved a Dice score of 0.82 with DTE, indicating good agreement between the two, given the limitations of each method.

physics.med-ph↗