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Duncan Stothers

Publications and source records attributed to Duncan Stothers.

3 recordsLinked to original sources

ADMIL: Attention-Distilled Multiple Instance Learning for Selective Foundation Model Inference in Pathology

Attention-based multiple instance learning (ABMIL) using pathology foundation model embeddings is effective for slide-level tasks, but exhaustive inference requires applying a large image encoder to every foreground tile despite the subsequent attention distribution often concentrating over a small subset of informative regions. We introduce ADMIL (Attention-Distilled Multiple Instance Learning), a selective-compute framework that distills an ABMIL teacher's attention into a lightweight tile-selection model, PriorNet. Using an EfficientNet architecture, PriorNet learns the teacher attention distribution from raw tile pixels with KL divergence; at inference, it scores the foreground pool, selects the top-K tiles, and invokes the expensive foundation model only on that subset before a selected-bag ABMIL student predicts the slide label. Across BRACS, PANDA, and CAMELYON16, ADMIL matches full-teacher headline performance at K=4, 8, and 128 tiles, respectively, avoiding >98% of foundation model (Virchow2) tile embeddings and model inference FLOPs. Random and teacher-attention oracle controls show that this result depends on task-relevant selection rather than tile-count reduction alone. Quantitative and qualitative analyses suggest that PriorNet recovers the teacher's tile ordering with high fidelity while focusing on task-relevant morphological regions. ADMIL shows that nearly all expensive tile encodings can be removed without sacrificing slide-level performance, providing a potential path for more efficient deployment in clinical settings where latency and compute costs are key considerations.

cs.CV

Radiation-Preserving Selective Imaging for Pediatric Hip Dysplasia: A Cross-Modal Ultrasound-Xray Policy with Limited Labels

We study an ultrasound-first, radiation-preserving policy for developmental dysplasia of the hip (DDH) that requests a radiograph only when needed. We (i) pretrain modality-specific encoders (ResNet-18) with SimSiam on a large unlabelled registry (37186 ultrasound; 19546 radiographs), (ii) freeze the backbones and fit small, measurement-faithful heads on DDH-relevant landmarks and measurements, (iii) calibrate a one-sided conformal deferral rule on ultrasound predictions that provides finite sample marginal coverage guarantees under exchangeability, using a held-out calibration set. Ultrasound heads predict Graf alpha, beta, and femoral head coverage; X-ray heads predict acetabular index (AI), center-edge (CE) angle and IHDI grade. On our held out labeled evaluation set, ultrasound measurement error is modest (e.g., alpha MAE ~= 9.7 degrees, coverage MAE ~= 14.0%), while radiographic probes achieve AI and CE MAEs of ~= 7.6 degrees and ~= 8.9 degrees, respectively. The calibrated US-only policy is explored across rule families (alpha-only; alpha OR coverage; alpha AND coverage), conformal miscoverage levels, and per-utility trade-offs using decision-curve analysis. Conservative settings yield high coverage with near-zero US-only rates; permissive settings (e.g., alpha OR coverage at larger deltas) achieve non-zero US-only throughput with expected coverage tradeoffs. The result is a simple, reproducible pipeline that turns limited labels into interpretable measurements and tunable selective imaging curves suitable for clinical handoff and future external validation.

cs.LG

Fitzpatrick Thresholding for Skin Image Segmentation

Accurate estimation of the body surface area (BSA) involved by a rash, such as psoriasis, is critical for assessing rash severity, selecting an initial treatment regimen, and following clinical treatment response. Attempts at segmentation of inflammatory skin disease such as psoriasis perform markedly worse on darker skin tones, potentially impeding equitable care. We assembled a psoriasis dataset sourced from six public atlases, annotated for Fitzpatrick skin type, and added detailed segmentation masks for every image. Reference models based on U-Net, ResU-Net, and SETR-small are trained without tone information. On the tuning split we sweep decision thresholds and select (i) global optima and (ii) per Fitzpatrick skin tone optima for Dice and binary IoU. Adapting Fitzpatrick specific thresholds lifted segmentation performance for the darkest subgroup (Fitz VI) by up to +31 % bIoU and +24 % Dice on UNet, with consistent, though smaller, gains in the same direction for ResU-Net (+25 % bIoU, +18 % Dice) and SETR-small (+17 % bIoU, +11 % Dice). Because Fitzpatrick skin tone classifiers trained on Fitzpatrick-17k now exceed 95 % accuracy, the cost of skin tone labeling required for this technique has fallen dramatically. Fitzpatrick thresholding is simple, model-agnostic, requires no architectural changes, no re-training, and is virtually cost free. We demonstrate the inclusion of Fitzpatrick thresholding as a potential future fairness baseline.

eess.IV