arXiv subjects

Duo Pan

Publications and source records attributed to Duo Pan.

13 recordsLinked to original sources

arXiv2026

Deep Learning for Semen Analysis in Male Infertility: Computer Vision, Multimodal Fusion, and Clinical Translation

Male infertility contributes substantially to the global infertility burden, and sperm analysis remains central to diagnosis, treatment planning, and assisted reproductive technology. Conventional semen evaluation, however, is labor-intensive, operator-dependent, and limited by inter- and intra-observer variability, motivating the development of objective and reproducible computational approaches. This review provides a comprehensive and perspective-oriented synthesis of artificial intelligence-driven sperm analysis, with a focus on computer vision, deep learning, multimodal fusion, robustness, and clinical translation. We first review task-specific methods for sperm detection and counting, tracking-based motility assessment, semantic and instance segmentation, morphology and defect classification, functional assessment, and genetic integrity evaluation. We then summarize public datasets, benchmarks, evaluation metrics, and emerging multimodal strategies that integrate microscopic images, time-lapse videos, CASA-derived parameters, DNA integrity assays, and clinical metadata. Beyond algorithmic performance, we discuss key barriers to real-world deployment, including data scarcity, cross-center domain shift, annotation inconsistency, interpretability, uncertainty calibration, privacy-preserving learning, and workflow integration. Finally, we outline a staged clinical translation roadmap spanning technical standardization, multicenter retrospective validation, silent prospective evaluation, human-in-the-loop clinical testing, ART outcome validation, regulatory approval, and post-market monitoring. By organizing the field from task-specific visual recognition to trustworthy multimodal reproductive intelligence, this review highlights both the progress and the unresolved challenges required to translate AI-driven sperm analysis into clinically meaningful decision support.

cs.CV↗

arXiv2025

Practical 1-um GHz fiber comb on silica-based platform

We present a fully stabilized 1-GHz Yb-fiber laser frequency comb built on silica substrates, utilizing "optical cubes" to house all optical components, ensuring long-term stability and practical operation. Both the femtosecond laser and f-to-2f interferometer are constructed to silica bricks, with a compact footprint of 290 mm * 250 mm, and a total weight of 1.8 kg. This system provides a stable repetition rate, offset frequency, and a supercontinuum spanning 460-1560 nm without requiring amplification. The carrier-envelop offset frequency exhibits exceptional in-loop stability, with a fractional frequency instability of 3.07* 10^(-18) at a 1 second averaging time, improving to 2.12*10^(-20) at a 10,000 second, maintaining uninterrupted operation for over 60 hours. This work demonstrates a high-performance GHz fiber-based frequency comb, paving the way for applications beyond laboratory environments, including dual-comb spectroscopy, astronomical spectrograph calibration, and portable optical clocks.

physics.optics↗

arXiv2025

Compact 780 nm Rb Optical Clock

We demonstrated a compact 780 nm rubidium optical clock, which includes an optical frequency standard and an optical frequency comb, with an optical volume of 11.6 liters. Unlike the 778 nm rubidium atomic clocks based on two-photon transition, here, the laser frequency is stabilized to the Rb D2 transition, using modulation transfer spectroscopy. This approach effectively eliminates Doppler background and provides a high signal to noise ratio and high sensitivity. A nearly 300 MHz microwave signal, whose phase exactly tracks that of the optical frequency standard, is generated via the optical frequency comb, yielding a frequency instability of 1.91 E-13 @1 s and 5.29 E-14 @1000 s in the electronic domain. To the best of our knowledge, this is the most precise frequency stabilization result for the first-excited-state transition of alkali metal atoms to date and represents the first optical clock based on this transition. These results offer a promising approach for the development of portable optical clocks.

physics.optics↗

arXiv2024

Single-Atomic-Ensemble Dual-Wavelength Optical Standard

We demonstrate a dual wavelength optical frequency standard based on the dual optical transition modulation transfer spectroscopy (DOTMTS) between different quantum transitions of the rubidium D1 (795 nm) and D2 (780 nm) lines. In a single rubidium atomic ensemble, modulation frequency sidebands from the 780 nm pump beam are simultaneously transferred to both the 780 nm and 795 nm probe lasers. The DOTMTS enables the simultaneous stabilization of 780 nm and 795 nm lasers on a single vapor cell. Both lasers exhibit a frequency instability in the low 10 ^(-14) range at 1 s of averaging, as estimated from the residual error signal. A theoretical model is developed based on the V type atomic level structure to illustrate the dual-wavelength spectroscopy. This approach can be extended to develop a multiwavelength optical frequency standard within a single atomic ensemble, broadening its applicability in fields such as precision metrology, wavelength standards, optical networks, and beyond.

physics.optics↗

arXiv2021

An inhibited laser

Traditional lasers function using resonant cavities, in which the round-trip optical path is exactly equal to an integer multiple of the intracavity wavelengths to constructively enhance the spontaneous emission rate. By taking advantage of the enhancement from the resonant cavity, the narrowest sub-10-mHz-linewidth laser and a $10^{-16}$-fractional-frequency-stability superradiant active optical clock (AOC) have been achieved. However, a laser with atomic spontaneous radiation being destructively inhibited in an anti-resonant cavity, where the atomic resonance is exactly between two adjacent cavity resonances, has not been reported. Herein, we experimentally demonstrate inhibited stimulated emission and termed it an inhibited laser. Compared with traditional superradiant AOCs, which exhibit superiority in terms of the high suppression of cavity noise, the suppression of the cavity-pulling effect of an inhibited laser can be further improved by a factor of $(2F/pi)^2$, i.e., 2.07 in this work, which was improved from 26 to 53 times. This study will guide further development of AOCs with better stability, and thus, it is significant for quantum metrology and may lead to new research in the laser physics and cavity quantum electrodynamics fields.

quant-ph↗

arXiv2021

Highly charged Nd$^{9+}$ Ion: A potential candidate of $\upmu$Hz linewidth optical clocks for probing fundamental physics

An active optical clock based on highly charged Nd$^{9+}$ ion is proposed for the first time. The clock can offer ultra-narrow linewidth at the $\upmu$Hz-level which is more than two-order of magnitude below the currently recorded laser linewidth. Operating at 605(90) nm superradiation lasing transition between the $5p^2~4f$ ground state and one of the long-lived $5p~4f^2$ excited state, the proposed active clock is inherently immune against the cavity noise which provides high stability. The clock serves as a sensitive probe with high sensitivity to variation of the fine-structure constant with accuracies below 10$^{-19}$ level. Sophisticated relativistic many-body methods are employed to predict related atomic properties that have corroborated the above findings.

physics.atom-ph↗

arXiv2020

Prospects for 10^{-18} Instability Laser Referenced on Thermal Atomic Ensembles

A thermal atomic ensemble-based laser source with superior frequency stability is proposed that relies on the accumulated contributions from an abundance of nonzero-transverse-velocity atomic ensembles. Compared with the traditional case in which only atoms with near-zero transverse velocities are utilized, the amplitude of the optical Ramsey fringes for a thermal calcium beam can be dramatically enhanced by three orders of magnitude or more, thus, the signal-to-noise ratio can be improved 33-fold. Based on the recent results of atomic interferometry-based laser stabilization, a quantum projection noise-limited frequency instability less than 2E-17/tau^0.5 is feasible. Such an ultrastable laser has promising applications in diverse areas, including metrology and astronomy.

physics.atom-ph↗

arXiv2020

Optical-lattice based Cs active clock with continual superradiant lasing signal

We demonstrate state-of-the-art technique of an active clock to provide a continuous superradiant lasing signal using an ensemble of trapped Cs atoms in the optical lattice. A magic wavelength of the proposed |7S1/2; F = 4, MF = 0> - |6P3/2; F = 3, MF = 0> clock transition in Cs atom is identified at 1181 nm for constructing the optical lattice. Pertinent optical lines are also found for pumping and repumping atoms from their ground states. A fractional uncertainty about 10-15 level to the clock frequency has been predicted by carrying out rigorous calculations of several atomic properties. The bad-cavity operational mode of the active clock is anticipated to improve its short-term stability remarkably by suppressing intrinsic thermal fluctuations. Thus, a composite clock system with better in both short-term and long-term stabilities can be built by combining the above proposed active clock with another high-accuracy passive optical clock.

physics.atom-ph↗

arXiv2019

Realization of phase locking in good-bad-cavity active optical clock

The residual cavity-pulling effect limits further narrowing of linewidth in dual-wavelength (DW) good-bad-cavity active optical clocks (AOCs). In this paper, we for the first time experimentally realize the cavity-length stabilization of the 1064/1470 nm DW-AOCs by utilizing the phase locking technique of two independent 1064 nm good-cavity lasers. The frequency tracking accuracy between the two main-cavities of DW-AOCs is better than $3 \times {10^{ - 16}}$ at 1 s, and can reach $1 \times {10^{ - 17}}$ at 1000 s. Each 1470 nm bad-cavity laser achieves a most probable linewidth of 53 Hz, which is about a quarter of that without phase locking. The influence of the asynchronous cavity-lengths variation between two DW laser systems is suppressed.

physics.atom-ph↗

arXiv2017

Atomic optical amplifier with narrow bandwidth optical filtering

Taking advantages of ultra-narrow bandwidth and high noise rejection performance of the Faraday anomalous dispersion optical filter (FADOF), simultaneously with the coherent amplification of atomic stimulated emission, a stimulated amplified Faraday anomalous dispersion optical filter (SAFADOF) at cesium 1470 nm is realized. The SAFADOF is able to significantly amplify very weak laser signals and reject noise in order to obtain clean signals in strong background. Experiment results show that, for a weak signal of 50 pW, the gain factor can be larger than 25000 (44 dB) within a bandwidth as narrow as 13 MHz. Having this ability to amplify weak signals with low background contribution, the SAFADOF finds outstanding potential applications in weak signal detections.

physics.optics↗

arXiv2015

Ultralong Faraday laser as an optical frequency standard

In this letter, we introduce the concept and experimentally demonstrate an ultralong Faraday laser as an optical frequency standard in principle. The ultralong Faraday laser is based on the Faraday anomalous dispersion optical filter (FADOF) with ultra-narrow bandwidth and the ultralong fiber extended cavity of $800$ m. The ultra-narrow FADOF is based on atomic transition line of isotope $^{87}$Rb, which has an ultra-narrow bandwidth of $26.0$ MHz and a transmission of $23.6\%$ at $780$ nm. Fibers of length $150$ m and $800$ m are used as ultralong fiber extended cavities, which provide optical feedback and give extremely small FSR of $0.667$ MHz and $0.125$ MHz, respectively. The mechanism of the proposed ultralong Faraday laser is to combine FADOF's ultra-narrow bandwidth and ultralong cavity's small free spectral range to limit the lasing frequency within FADOF bandwidth covered by the semiconductor gain. The active lasing frequency of the ultralong Faraday laser is determined by the center frequency of FADOF transmission, which is corresponding to atomic transition $5^{2}S_{1/2},\ F = 2 \ \rightarrow\ 5^{2}P_{3/2},\ F^{\prime} = 2,\ 3$ of isotope $^{87}$Rb. The Allan deviation of the fractional frequency of the ultralong Faraday laser output signal in 0.1 s -- 1 s measuring time is around $1\times10^{-11}$.

physics.atom-ph↗

arXiv2014

Dual-wavelength active optical clock

We experimentally realize the dual-wavelength active optical clock for the first time. As the Cs cell temperature is kept between 118 $^{\circ }C$ and 144 $^{\circ }C$, both the 1359 nm and the 1470 nm stimulated emission output of Cs four-level active optical clock are detected. The 1470 nm output linewidth of each experimental setup of Cs four-level active optical clock is measured to be 590 Hz with the main cavity length unstabilized. To stabilize the cavity length of active optical clock, the experimental scheme of 633 nm and 1359 nm good-bad cavity dual-wavelength active optical clock is proposed, where 633 nm and 1359 nm stimulated emission is working at good-cavity and bad-cavity regime respectively. The cavity length is stabilized by locking the 633 nm output frequency to a super-cavity with the Pound-Drever-Hall (PDH) technique. The frequency stability of 1359 nm bad-cavity stimulated emission output is then expected to be further improved by at least 1 order of magnitude than the 633 nm PDH system due to the suppressed cavity pulling effect of active optical clock, and the quantum limited linewidth of 1359 nm output is estimated to be 77.6 mHz.

physics.atom-ph↗

arXiv2014

Hanle detection for optical clocks

Considering the strong inhomogeneous spatial polarization and intensity distribution of spontaneous decay fluorescence due to the Hanle effect, we propose and demonstrate a universe Hanle detection configuration of electron-shelving method for optical clocks. Experimental results from Ca atomic beam optical frequency standard with 423 nm electron-shelving method show that a designed Hanle detection geometry with optimized magnetic field direction, detection laser beam propagation and polarization direction, and detector position can improve the fluorescence collection rate by more than one order of magnitude comparing with that of inefficient geometry. With the fixed 423 nm fluorescence, the improved 657 nm optical frequency standard signal intensity is presented. And the potential application of the Hanle detection geometry designed for facilitating the fluorescence collection for optical lattice clock with a limited solid angle of the fluorescence collection has been discussed. This Hanle detection configuration is also effective for ion detection in ion optical clock and quantum information experiments. Besides, a cylinder fluorescence collection structure is designed to increase the solid angle of the fluorescence collection in Ca atomic beam optical frequency standard.

physics.atom-ph↗