arXiv subjects

Durba Bhattacharya

Publications and source records attributed to Durba Bhattacharya.

8 recordsLinked to original sources

arXiv2026

The Bayesian Reflex: Online Learning as the Autonomic Nervous System of Modern and Future AI

This chapter introduces the Bayesian reflex -- an analogy with the autonomic nervous system -- as a unifying framework for online learning in AI. Bayesian online algorithms automatically maintain equilibrium in dynamic environments via three mechanisms: belief maintenance through probabilistic representations, sequential updating via Bayes' theorem, and uncertainty-driven action balancing exploration and exploitation. We survey online Bayesian methods, highlighting two computational principles: the look-up table principle for sequential inference in function space, and the ellipsoidal decomposition framework for nearly exact i.i.d. sampling from arbitrary posteriors. These principles are generalized across dynamic emulation, nonparametric state-space models, circular time series, inverse regression for climate model evaluation, and deep architectures via Recursive Gaussian Processes. Decision-making is explored via Thompson sampling and restless bandits. We extend the framework to assess infinite series convergence (applied to climate dynamics and the Riemann Hypothesis), model prime number distributions leading to the discovery of 184 strong Mersenne prime candidates, detect stationarity, and characterize point processes. The Bayesian reflex provides a foundational infrastructure for adaptive AI that continuously learns in a complex world.

stat.ME↗

arXiv2026

Bayesian Nonparametrics for Gene-Gene and Gene-Environment Interactions in Case-Control Studies: A Synthesis and Extension

Gene-gene and gene-environment interactions are widely believed to play significant roles in explaining the variability of complex traits. While substantial research exists in this area, a comprehensive statistical framework that addresses multiple sources of uncertainty simultaneously remains lacking. In this article, we synthesize and propose extension of a novel class of Bayesian nonparametric approaches that account for interactions among genes, loci, and environmental factors while accommodating uncertainty about population substructure. Our contribution is threefold: (1) We provide a unified exposition of hierarchical Bayesian models driven by Dirichlet processes for genetic interactions, clarifying their conceptual advantages over traditional regression approaches; (2) We shed light on new computational strategies that combine transformation-based MCMC with parallel processing for scalable inference; and (3) We present enhanced hypothesis testing procedures for identifying disease-predisposing loci.Through applications to myocardial infarction data, we demonstrate how these methods offer biological insights not readily obtainable from standard approaches. Our synthesis highlights the advantages of Bayesian nonparametric thinking in genetic epidemiology while providing practical guidance for implementation.

stat.ME↗

arXiv2025

Bayes Meets Riemann Again: Large Prime Discovery and Re-emergence of the Bone of Contention

Prime numbers have fascinated mathematicians since antiquity, with ongoing efforts to uncover both their properties and ever-larger examples. While giant primes rarely aid cryptography, they find use in areas such as locally decodable codes. Large prime-hunting, often brute-force in nature, is conceptually linked to the Riemann Hypothesis and the prime number theorem, which portrays prime distribution as essentially random. This motivates a statistical perspective, with Bayesian methodology providing a natural foundation. We show that the prime number theorem suggests a nonhomogeneous Poisson process for prime counts, yielding primes as waiting times. This process agrees with the prime number theorem, asymptotic results, and prime gap properties. Building on it, we develop a recursive Bayesian theory for large prime prediction and Riemann Hypothesis validation. The approach matches traditional but computationally infeasible non-recursive Bayesian formulations in the limit, and it strongly falsifies the Riemann Hypothesis. Finally, we propose a computational method using Transformation-based MCMC to simulate recursive posterior predictives. A simple change of variable enables simulation of Mersenne prime exponents. With modest computing resources, we identified 259 primes over 140 million, including 184 strong Mersenne candidates corresponding to potential primes with 42--242 million digits.

math.GM↗

arXiv2023

Gender-Based Comparative Study of Type 2 Diabetes Risk Factors in Kolkata, India: A Machine Learning Approach

Type 2 diabetes mellitus represents a prevalent and widespread global health concern, necessitating a comprehensive assessment of its risk factors. This study aimed towards learning whether there is any differential impact of age, Lifestyle, BMI and Waist to height ratio on the risk of Type 2 diabetes mellitus in males and females in Kolkata, West Bengal, India based on a sample observed from the out-patient consultation department of Belle Vue Clinic in Kolkata. Various machine learning models like Logistic Regression, Random Forest, and Support Vector Classifier, were used to predict the risk of diabetes, and performance was compared based on different predictors. Our findings indicate a significant age-related increase in risk of diabetes for both males and females. Although exercising and BMI was found to have significant impact on the risk of Type 2 diabetes in males, in females both turned out to be statistically insignificant. For both males and females, predictive models based on WhtR demonstrated superior performance in risk assessment compared to those based on BMI. This study sheds light on the gender-specific differences in the risk factors for Type 2 diabetes, offering valuable insights that can be used towards more targeted healthcare interventions and public health strategies.

cs.LG↗

arXiv2020

Hierarchical Bayesian Approach for Improving Weights for Solving Multi-Objective Route Optimization Problem

The weighted sum method is a simple and widely used technique that scalarizes multiple conflicting objectives into a single objective function. It suffers from the problem of determining the appropriate weights corresponding to the objectives. This paper proposes a novel Hierarchical Bayesian model based on Multinomial distribution and Dirichlet prior to refine the weights for solving such multi-objective route optimization problems. The model and methodologies revolve around data obtained from a small scale pilot survey. The method aims at improving the existing methods of weight determination in the field of Intelligent Transport Systems as data driven choice of weights through appropriate probabilistic modelling ensures, on an average, much reliable results than non-probabilistic techniques. Application of this model and methodologies to simulated as well as real data sets revealed quite encouraging performances with respect to stabilizing the estimates of weights.

cs.AI↗

arXiv2020

A Non-Gaussian, Nonparametric Structure for Gene-Gene and Gene-Environment Interactions in Case-Control Studies Based on Hierarchies of Dirichlet Processes

It is becoming increasingly clear that complex interactions among genes and environmental factors play crucial roles in triggering complex diseases. Thus, understanding such interactions is vital, which is possible only through statistical models that adequately account for such intricate, albeit unknown, dependence structures. Bhattacharya & Bhattacharya (2016b) attempt such modeling, relating finite mixtures composed of Dirichlet processes that represent unknown number of genetic sub-populations through a hierarchical matrix-normal structure that incorporates gene-gene interactions, and possible mutations, induced by environmental variables. However, the product dependence structure implied by their matrix-normal model seems to be too simple to be appropriate for general complex, realistic situations. In this article, we propose and develop a novel nonparametric Bayesian model for case-control genotype data using hierarchies of Dirichlet processes that offers a more realistic and nonparametric dependence structure between the genes, induced by the environmental variables. In this regard, we propose a novel and highly parallelisable MCMC algorithm that is rendered quite efficient by the combination of modern parallel computing technology, effective Gibbs sampling steps, retrospective sampling and Transformation based Markov Chain Monte Carlo (TMCMC). We use appropriate Bayesian hypothesis testing procedures to detect the roles of genes and environment in case-control studies. We apply our ideas to 5 biologically realistic case-control genotype datasets simulated under distinct set-ups, and obtain encouraging results in each case. We finally apply our ideas to a real, myocardial infarction dataset, and obtain interesting results on gene-gene and gene-environment interaction, while broadly agreeing with the results reported in the literature.

stat.AP↗

arXiv2018

A Bayesian Semiparametric Approach to Learning About Gene-Gene Interactions in Case-Control Studies

Gene-gene interactions are often regarded as playing significant roles in influencing variabilities of complex traits. Although much research has been devoted to this area, to date a comprehensive statistical model that addresses the various sources of uncertainties, seem to be lacking. In this paper, we propose and develop a novel Bayesian semiparametric approach composed of finite mixtures based on Dirichlet processes and a hierarchical matrix-normal distribution that can comprehensively account for the unknown number of sub-populations and gene-gene interactions. Then, by formulating novel and suitable Bayesian tests of hypotheses we attempt to single out the roles of the genes, individually, and in interaction with other genes, in case-control studies. We also attempt to identify the significant loci associated with the disease. Our model facilitates a highly efficient parallel computing methodology, combining Gibbs sampling and Transformation based MCMC (TMCMC). Application of our ideas to biologically realistic data sets revealed quite encouraging performance. We also applied our ideas to a real, myocardial infarction dataset, and obtained interesting results that partly agree with, and also complement, the existing works in this area, to reveal the importance of sophisticated and realistic modeling of gene-gene interactions.

stat.AP↗

arXiv2017

Effects of Gene-Environment and Gene-Gene Interactions in Case-Control Studies: A Novel Bayesian Semiparametric Approach

Cognizance of gene-environment interactions may help prevent or detain the onset of complex diseases like cardiovascular disease, cancer, type2 diabetes, autism or asthma by adjustments to lifestyle. In this regard, we extend the Bayesian semiparametric gene-gene interaction model of Bhattacharya & Bhattacharya (2015) to include the possibility of influencing gene-gene interactions by environmental variables and possible mutations caused by the environment. Our model accounts for the unknown number of genetic sub-populations via finite mixtures composed of Dirichlet processes, which are related to each other through a hierarchical matrix normal structure responsible for inducing gene-gene interactions and possible mutations in association with environmental variables. We also extend the Bayesian hypotheses testing procedures of Bhattacharya & Bhattacharya (2015) to detect the roles of genes and their interactions, environment and the influence of environment on gene-gene interactions, in case-control studies. We develop an effective parallel computing methodology, which harnesses the power of parallel processing technology to the efficiencies of our conditionally independent Gibbs sampling and Transformation based MCMC (TMCMC) methods.Applications of our model and methods to simulation studies with biologically realistic case-control genotype datasets obtained under five distinct set-ups yield encouraging results in each case. We followed these up by application of our ideas to a real, case-control based genotype dataset on early onset of myocardial infarction. Beside being in broad agreement with the reported literature on this dataset, the results obtained give some interesting insights to the differential effect of gender on MI.

stat.AP↗