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E. Alvarez-Lacalle

Publications and source records attributed to E. Alvarez-Lacalle.

5 recordsLinked to original sources

Molecular Model of the Contractile Ring

We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction. We demonstrate the crucial role of actin polymerization and depolymerization throughout cytokinesis, and the dominance of viscous dissipation in the dynamics. The physical origin of two phases in cytokinesis dynamics ("biphasic cytokinesis") follows from a limitation on the actin density. The model is consistent with a wide range of measurements of the midzone of dividing animal cells.

physics.bio-ph↗

A quantitative analysis of concepts and semantic structure in written language: Long range correlations in dynamics of texts

Understanding texts requires memory: the reader has to keep in mind enough words to create meaning. This calls for a relation between the memory of the reader and the structure of the text. To investigate this interaction, we first identify a connectivity matrix defined by co-occurrence of words in the text. A vector space of words characterizing the text is spanned by the principal directions of this matrix. It is useful to think of these weighted combinations of words as representing ``concepts''. As the reader follows the text, the set of words in her window of attention follows a dynamical motion among these concepts. We observe long range power law correlations in this trajectory. By explicitly constructing surrogate hierarchical texts, we demonstrate that the power law originates from structural organization of texts into subunits such as chapters and paragraphs.

physics.soc-ph↗

Spontaneous pinch-off in rotating Hele-Shaw flows

The dynamics of the interface between two immiscible fluids in a rotating Hele-Shaw cell are studied experimentally, theoretically and by phase-field simulations of the H-S equations. As the central, denser fluid is centrifuged, it forms fingering patterns with long, thin radial filaments ended by a droplet, alternating with incoming fingers of the outer fluid. Simulations show the length (width) of the filaments to grow (decay) roughly exponentially, and the incoming finger tips to asymptotically approach a finite radius for n-fold symmetric initial conditions; these thus tend to a stationary-shape, which is calculated. The filament width decays with a time constant which depends only on the viscosity contrast, whereas its length exhibits a completely universal growth rate, related to the run away of an isolated droplet, for which we give an exact solution. The exponential behavior is clear for high, but not low viscosity contrasts A. Both experiments and simulations show systematic pinch-off of the droplets at the tips of the filaments for low and not for high A. A lubrication approximation is derived and successfully accounts for the filament thinning; it explains why pure exponential thinning is not observed for low A, and it could clarify the presence or absence of finite-time pinch-off, since the (morphological) agreement of experiments and simulations suggests that this phenomenon is contained in the Hele-Shaw equations. For low A, the experimental time constant appears to be different from that predicted by standard Hele-Shaw boundary conditions and observed in simulations. An effective slip condition for the Poiseuille flow of inner liquid across the cell gap in the case of two liquids gives a possible explanation of this discrepancy.

physics.flu-dyn↗

Systematic weakly nonlinear analysis of interfacial instabilities in Hele-Shaw flows

We develop a systematic method to derive all orders of mode couplings in a weakly nonlinear approach to the dynamics of the interface between two immiscible viscous fluids in a Hele-Shaw cell. The method is completely general. It includes both the channel geometry driven by gravity and pressure, and the radial geometry with arbitrary injection and centrifugal driving. We find the finite radius of convergence of the mode-coupling expansion. In the channel geometry we carry out the calculation up to third-order couplings, which is necessary to account for the time-dependent Saffman-Taylor finger solution and the case of zero viscosity contrast. Both in the channel and the radial geometries, the explicit results provide relevant analytical information about the role that the viscosity contrast and the surface tension play in the dynamics. We finally check the quantitative validity of different orders of approximation against a physically relevant, exact time-dependent solution. The agreement between the low order approximations and the exact solution is excellent within the radius of convergence, and reasonably good even beyond that.

nlin.PS↗