arXiv subjects

E. Chang

Publications and source records attributed to E. Chang.

14 recordsLinked to original sources

arXiv2023

Metasurface-enhanced mid-infrared spectrochemical imaging of tissues

Label-free and nondestructive mid-infrared vibrational hyperspectral imaging is emerging as an important ex-vivo tissue analysis tool, providing spatially resolved biochemical information critical to understanding physiological and pathological processes. However, the chemically complex and spatially heterogeneous composition of tissue specimens and the inherently weak interaction of infrared light with biomolecules limit the analytical performance of infrared absorption spectroscopy. Here, we introduce an advanced mid-infrared spectrochemical tissue imaging modality using metasurfaces that support strong surface-localized electromagnetic fields to capture quantitative molecular maps of large-area murine brain-tissue sections. Our approach leverages polarization-multiplexed multi-resonance plasmonic metasurfaces to simultaneously detect many different functional biomolecules. The resulting surface-enhanced mid-infrared spectral imaging (SE-MIRSI) method eliminates the non-specific effects of bulk tissue morphology on the quantitative analysis of fingerprint spectra and improves the chemical selectivity. We show that the metasurface enhancement increases the retrieval of amide I and II absorption bands associated with secondary structures of proteins. Moreover, we demonstrate that plasmonic metasurfaces enhance the chemical contrast in infrared images and enable the detection of ultrathin tissue regions that are not otherwise visible to conventional mid-infrared spectral imaging. While we tested our approach on murine brain tissue sections, this chemical imaging method is well-suited for any tissue type, which significantly broadens the potential impacts of our method for both translational research and clinical histopathology.

physics.optics↗

arXiv2019

Measuring the Orbital Parameters of Radial Velocity Systems in Mean Motion Resonance---a Case Study of HD 200964

The presence of mean motion resonances (MMRs) complicates analysis and fitting of planetary systems observed through the radial velocity (RV) technique. MMR can allow planets to remain stable in regions of phase space where strong planet-planet interactions would otherwise destabilize the system. These stable orbits can occupy small phase space volumes, allowing MMRs to strongly constrain system parameters, but making searches for stable orbital parameters challenging. Furthermore, libration of the resonant angle and dynamical interaction between the planets introduces another, long period variation into the observed RV signal, complicating analysis of the periods of the planets in the system. We discuss this phenomenon using the example of HD 200964. By searching through parameter space and numerically integrating each proposed set of planetary parameters to test for long term stability, we find stable solutions in the 7:5 and 3:2 MMRs in addition to the originally identified 4:3 MMR. The 7:5 configuration provides the best match to the data, while the 3:2 configuration provides the most easily understood formation scenario. In reanalysis of the originally published shorter-baseline data, we find fits in both the 4:3 and 3:2 resonances, but not the 7:5. Because the time baseline of the data is less than the resonant libration period, the current best fit to the data may not reflect the actual resonant configuration. In the absence of a full sample of the longer libration period, we find that it is of paramount importance to incorporate long term stability when fitting for the system's orbital configuration.

astro-ph.EP↗

arXiv2015

Quarkonium-Nucleus Bound States from Lattice QCD

Quarkonium-nucleus systems are composed of two interacting hadronic states without common valence quarks, which interact primarily through multi-gluon exchanges, realizing a color van der Waals force. We present lattice QCD calculations of the interactions of strange and charm quarkonia with light nuclei. Both the strangeonium-nucleus and charmonium-nucleus systems are found to be relatively deeply bound when the masses of the three light quarks are set equal to that of the physical strange quark. Extrapolation of these results to the physical light-quark masses suggests that the binding energy of charmonium to nuclear matter is B < 40 MeV.

hep-lat↗

arXiv2015

Magnetic moments of light nuclei from lattice quantum chromodynamics

We present the results of lattice QCD calculations of the magnetic moments of the lightest nuclei, the deuteron, the triton and ${}^3$He, along with those of the neutron and proton. These calculations, performed at quark masses corresponding to $m_π\sim 800$ MeV, reveal that the structure of these nuclei at unphysically heavy quark masses closely resembles that at the physical quark masses. In particular, we find that the magnetic moment of ${}^3$He differs only slightly from that of a free neutron, as is the case in nature, indicating that the shell-model configuration of two spin-paired protons and a valence neutron captures its dominant structure. Similarly a shell-model-like moment is found for the triton, $μ_{{}^3{\rm H}} \sim μ_p$. The deuteron magnetic moment is found to be equal to the nucleon isoscalar moment within the uncertainties of the calculations.

hep-lat↗

arXiv2013

Trawling for transits in a sea of noise: A Search for Exoplanets by Analysis of WASP Optical Lightcurves and Follow-up (SEAWOLF)

Studies of transiting Neptune-size planets orbiting close to nearby bright stars can inform theories of planet formation because mass and radius and therefore mean density can be accurately estimated and compared with interior models. The distribution of such planets with stellar mass and orbital period relative to their Jovian-mass counterparts can test scenarios of orbital migration, and whether "hot" (period < 10d) Neptunes evolved from "hot" Jupiters as a result of mass loss. We searched 1763 late K and early M dwarf stars for transiting Neptunes by analyzing photometry from the Wide Angle Search for Planets and obtaining high-precision ($<10^{-3}$) follow-up photometry of stars with candidate transit signals. One star in our sample (GJ 436) hosts a previously reported hot Neptune. We identified 92 candidate signals among 80 other stars and carried out 148 observations of predicted candidate transits with 1-2 m telescopes. Data on 70 WASP signals rules out transits for 39 of them; 28 other signals are ambiguous and/or require more data. Three systems have transit-like events in follow-up photometry and we plan additional follow-up observations. On the basis of no confirmed detections in our survey, we place an upper limit of 10.25% on the occurrence of hot Neptunes around late K and early M dwarfs (95% confidence). A single confirmed detection would translate to an occurrence of 5.3$\pm$4.4%. The latter figure is similar to that from Doppler surveys, suggesting that GJ 436b may be the only transiting hot Neptune in our sample. Our analysis of Kepler data for similar but more distant late-type dwarfs yields an occurrence of 0.32$\pm$0.21%. Depending on which occurrence is applicable, we estimate that the Next Generation Transit Survey will discover either ~60 or ~1000 hot Neptunes around late K and early M-type dwarfs.

astro-ph.EP↗

arXiv2013

Nucleon-Nucleon Scattering Parameters in the Limit of SU(3) Flavor Symmetry

The scattering lengths and effective ranges that describe low-energy nucleon-nucleon scattering are calculated in the limit of SU(3)-flavor symmetry at the physical strange-quark mass with Lattice Quantum Chromodynamics. The calculations are performed with an isotropic clover discretization of the quark action in three volumes with spatial extents of L \sim 3.4 fm, 4.5fm and 6.7 fm, and with a lattice spacing of b \sim 0.145 fm. With determinations of the energies of the two-nucleon systems (both of which contain bound states at these up and down quark masses) at rest and moving in the lattice volume, Luscher's method is used to determine the low-energy phase shifts in each channel, from which the scattering length and effective range are obtained. The scattering parameters, in the 1S0 channel are found to be m_pi a^(1S0) = 9.50^{+0.78}_{-0.69}^{+1.10}_{-0.80} and m_pi r^(1S0) = {4.61^{+0.29}_{-0.31}^{+0.24}_{-0.26}, and in the 3S1 channel are m_pi a^(3S1) = 7.45^{+0.57}_{-0.53}^{+0.71}_{-0.49} and m_pi r^(3S1) = 3.71^{+0.28}_{-0.31}^{+0.28}_{-0.35}. These values are consistent with the two-nucleon system exhibiting Wigner's supermultiplet symmetry, which becomes exact in the limit of large-N_c. In both spin channels, the phase shifts change sign at higher momentum, near the start of the t-channel cut, indicating that the nuclear interactions have a repulsive core even at the SU(3)-symmetric point.

hep-lat↗

arXiv2012

Light Nuclei and Hypernuclei from Quantum Chromodynamics in the Limit of SU(3) Flavor Symmetry

The binding energies of a range of nuclei and hypernuclei with atomic number A <= 4 and strangeness |s| <= 2, including the deuteron, di-neutron, H-dibaryon, 3He, Lambda 3He, Lambda 4He, and Lambda Lambda 4He, are calculated in the limit of flavor-SU(3) symmetry at the physical strange quark mass with quantum chromodynamics (without electromagnetic interactions). The nuclear states are extracted from Lattice QCD calculations performed with n_f=3 dynamical light quarks using an isotropic clover discretization of the quark-action in three lattice volumes of spatial extent L ~ 3.4 fm, 4.5 fm and 6.7 fm, and with a single lattice spacing b ~ 0.145 fm.

hep-lat↗

arXiv2012

Hyperon-Nucleon Interactions and the Composition of Dense Nuclear Matter from Quantum Chromodynamics

The low-energy neutron-Sigma^- interactions determine, in part, the role of the strange quark in dense matter, such as that found in astrophysical environments. The scattering phase shifts for this system are obtained from a numerical evaluation of the QCD path integral using the technique of Lattice QCD. Our calculations, performed at a pion mass of m_pi ~ 389 MeV in two large lattice volumes, and at one lattice spacing, are extrapolated to the physical pion mass using effective field theory. The interactions determined from QCD are consistent with those extracted from hyperon-nucleon experimental data within uncertainties, and strengthen theoretical arguments that the strange quark is a crucial component of dense nuclear matter.

hep-lat↗

arXiv2011

The I=2 pipi S-wave Scattering Phase Shift from Lattice QCD

The pi+pi+ s-wave scattering phase-shift is determined below the inelastic threshold using Lattice QCD. Calculations were performed at a pion mass of m_pi~390 MeV with an anisotropic n_f=2+1 clover fermion discretization in four lattice volumes, with spatial extent L~2.0, 2.5, 3.0 and 3.9 fm, and with a lattice spacing of b_s~0.123 fm in the spatial direction and b_t b_s/3.5 in the time direction. The phase-shift is determined from the energy-eigenvalues of pi+pi+ systems with both zero and non-zero total momentum in the lattice volume using Luscher's method. Our calculations are precise enough to allow for a determination of the threshold scattering parameters, the scattering length a, the effective range r, and the shape-parameter P, in this channel and to examine the prediction of two-flavor chiral perturbation theory: m_pi^2 a r = 3+O(m_pi^2/Lambda_chi^2). Chiral perturbation theory is used, with the Lattice QCD results as input, to predict the scattering phase-shift (and threshold parameters) at the physical pion mass. Our results are consistent with determinations from the Roy equations and with the existing experimental phase shift data.

hep-lat↗

arXiv2011

The Deuteron and Exotic Two-Body Bound States from Lattice QCD

Results of a high-statistics, multi-volume Lattice QCD exploration of the deuteron, the di-neutron, the H-dibaryon, and the Xi-Xi- system at a pion mass of m ~ 390 MeV are presented. Calculations were performed with an anisotropic n_f = 2+1 Clover discretization in four lattice volumes of spatial extent L ~ 2.0, 2.5, 3.0 and 4.0 fm, with a lattice spacing of b_s ~ 0.123 fm in the spatial-direction, and b_t ~ b_s/3.5 in the time-direction. The Xi-Xi- is found to be bound by B_{Xi-Xi-} = 14.0(1.4)(6.7) MeV, consistent with expectations based upon phenomenological models and low-energy effective field theories constrained by nucleon-nucleon and hyperon-nucleon scattering data at the physical light-quark masses. We find weak evidence that both the deuteron and the di-neutron are bound at this pion mass, with binding energies of B_d = 11(05)(12) MeV and B_{nn} = 7.1(5.2)(7.3) MeV, respectively. With an increased number of measurements and a refined analysis, the binding energy of the H-dibaryon is B_H = 13.2(1.8)(4.0) MeV at this pion mass, updating our previous result.

hep-lat↗

arXiv2011

Present Constraints on the H-dibaryon at the Physical Point from Lattice QCD

The current constraints from lattice QCD on the existence of the H-dibaryon are discussed. With only two significant lattice QCD calculations of the H-dibaryon binding energy at approximately the same lattice spacing, the forms of the chiral and continuum extrapolations to the physical point are not determined. In this brief report, we consider the constraints on the H-dibaryon imposed by two simple chiral extrapolations. In both instances, the extrapolation to the physical pion mass allows for a bound H-dibaryon or a near-threshold scattering state. Further lattice QCD calculations are required to clarify this situation.

hep-lat↗

arXiv2011

Evidence for a Bound H-dibaryon from Lattice QCD

We present evidence for the existence of a bound H-dibaryon, an I=0, J=0, s=-2 state with valence quark structure uuddss, at a pion mass of m_pi ~ 389 MeV. Using the results of Lattice QCD calculations performed on four ensembles of anisotropic clover gauge-field configurations, with spatial extents of L ~ 2.0, 2.5, 3.0 and 3.9 fm at a spatial lattice spacing of b ~ 0.123 fm, we find an H-dibaryon bound by B = 16.6 +- 2.1 +- 4.6 MeV at a pion mass of m_pi ~ 389 MeV.

hep-lat↗

arXiv2011

High Statistics Analysis using Anisotropic Clover Lattices: (IV) Volume Dependence of Light Hadron Masses

The volume dependence of the octet baryon masses and relations among them are explored with Lattice QCD. Calculations are performed with n_f=2+1 clover fermion discretization in four lattice volumes, with spatial extent L ~ 2.0, 2.5, 3.0 and 3.9 fm, with an anisotropic lattice spacing of b_s ~ 0.123 fm in the spatial direction, and b_t = b_s/3.5 in the time direction, and at a pion mass of m_pi ~ 390 MeV. The typical precision of the ground-state baryon mass determination is ~0.2%, enabling a precise exploration of the volume dependence of the masses, the Gell-Mann--Okubo mass relation, and of other mass combinations. A comparison of the volume dependence with the predictions of heavy baryon chiral perturbation theory is performed in both the SU(2)_L X SU(2)_R and SU(3)_L X SU(3)_R expansions. Predictions of the three-flavor expansion for the hadron masses are found to describe the observed volume dependences reasonably well. Further, the Delta-N-pi axial coupling constant is extracted from the volume dependence of the nucleon mass in the two-flavor expansion, with only small modifications in the three-flavor expansion from the inclusion of kaons and etas. At a given value of m_pi L, the finite-volume contributions to the nucleon mass are predicted to be significantly smaller at m_pi ~ 140 MeV than at m_pi ~ 390 MeV due to a coefficient that scales as ~ m_pi^3. This is relevant for the design of future ensembles of lattice gauge-field configurations. Finally, the volume dependence of the pion and kaon masses are analyzed with two-flavor and three-flavor chiral perturbation theory.

hep-lat↗

arXiv2005

Exciton binding energies in carbon nanotubes from two-photon photoluminescence

One- and two-photon luminescence excitation spectroscopy showed a series of distinct excitonic states in single-walled carbon nanotubes. The energy splitting between one- and two-photon-active exciton states of different wavefunction symmetry is the fingerprint of excitonic interactions in carbon nanotubes. We determine exciton binding energies of 0.3-0.4 eV for different nanotubes with diameters between 0.7 and 0.9 nm. Our results, which are supported by ab-initio calculations of the linear and non-linear optical spectra, prove that the elementary optical excitations of carbon nanotubes are strongly Coulomb-correlated, quasi-one dimensionally confined electron-hole pairs, stable even at room temperature. This alters our microscopic understanding of both the electronic structure and the Coulomb interactions in carbon nanotubes, and has direct impact on the optical and transport properties of novel nanotube devices.

cond-mat.mtrl-sci↗