arXiv subjects

E. Gudowska-Nowak

Publications and source records attributed to E. Gudowska-Nowak.

8 recordsLinked to original sources

arXiv2016

Seeking for a fingerprint: analysis of point processes in actigraphy recording

Motor activity of humans displays complex temporal fluctuations which can be characterized by scale-invariant statistics, thus documenting that structure and fluctuations of such kinetics remain similar over a broad range of time scales. Former studies on humans regularly deprived of sleep or suffering from sleep disorders predicted change in the invariant scale parameters with respect to those representative for healthy subjects. In this study we investigate the signal patterns from actigraphy recordings by means of characteristic measures of fractional point processes. We analyse spontaneous locomotor activity of healthy individuals recorded during a week of regular sleep and a week of chronic partial sleep deprivation. Behavioural symptoms of lack of sleep can be evaluated by analysing statistics of duration times during active and resting states, and alteration of behavioural organization can be assessed by analysis of power laws detected in the event count distribution, distribution of waiting times between consecutive movements and detrended fluctuation analysis of recorded time series. We claim that among different measures characterizing complexity of the actigraphy recordings and their variations implied by chronic sleep distress, the exponents characterizing slopes of survival functions in resting states are the most effective biomarkers distinguishing between healthy and sleep-deprived groups.

q-bio.NC↗

arXiv2014

Heat and work distributions for mixed Gauss-Cauchy process

We analyze energetics of a non-Gaussian process described by a stochastic differential equation of the Langevin type. The process represents a paradigmatic model of a nonequilibrium system subject to thermal fluctuations and additional external noise, with both sources of perturbations considered as additive and statistically independent forcings. We define thermodynamic quantities for trajectories of the process and analyze contributions to mechanical work and heat. As a working example we consider a particle subjected to a drag force and two independent Levy white noises with stability indices $α=2$ and $α=1$. The fluctuations of dissipated energy (heat) and distribution of work performed by the force acting on the system are addressed by examining contributions of Cauchy fluctuations to either bath or external force acting on the system.

cond-mat.stat-mech↗

arXiv2008

Transport in a Levy ratchet: Group velocity and distribution spread

We consider the motion of an overdamped particle in a periodic potential lacking spatial symmetry under the influence of symmetric Lévy noise, being a minimal setup for a ``Lévy ratchet.'' Due to the non-thermal character of the Lévy noise, the particle exhibits a motion with a preferred direction even in the absence of whatever additional time-dependent forces. The examination of the Lévy ratchet has to be based on the characteristics of directionality which are different from typically used measures like mean current and the dispersion of particles' positions, since these get inappropriate when the moments of the noise diverge. To overcome this problem, we discuss robust measures of directionality of transport like the position of the median of the particles displacements' distribution characterizing the group velocity, and the interquantile distance giving the measure of the distributions' width. Moreover, we analyze the behavior of splitting probabilities for leaving an interval of a given length unveiling qualitative differences between the noises with Lévy indices below and above unity. Finally, we inspect the problem of the first escape from an interval of given length revealing independence of exit times on the structure of the potential.

cond-mat.stat-mech↗

arXiv2007

Stationary states in Langevin dynamics under asymmetric Lévy noises

Properties of systems driven by white non-Gaussian noises can be very different from these systems driven by the white Gaussian noise. We investigate stationary probability densities for systems driven by $α$-stable Lévy type noises, which provide natural extension to the Gaussian noise having however a new property mainly a possibility of being asymmetric. Stationary probability densities are examined for a particle moving in parabolic, quartic and in generic double well potential models subjected to the action of $α$-stable noises. Relevant solutions are constructed by methods of stochastic dynamics. In situations where analytical results are known they are compared with numerical results. Furthermore, the problem of estimation of the parameters of stationary densities is investigated.

cond-mat.stat-mech↗

arXiv2007

Coexistence of resonant activation and noise enhanced stability in a model of tumor-host interaction: Statistics of extinction times

We study a Langevin equation derived from the Michaelis-Menten (MM) phenomenological scheme for catalysis accompanying a spontaneous replication of molecules, which may serve as a simple model of cell-mediated immune surveillance against cancer. We examine how two different and statistically independent sources of noise - dichotomous multiplicative noise and additive Gaussian white noise - influence the population's extinction time. This quantity is identified as the mean first passage time of the system across the zero population state. We observe the effects of resonant activation (RA) and noise-enhanced stability (NES) and we report the evidence for competitive co-occurrence of both phenomena in a given regime of noise parameters. We discuss the statistics of first passage times in this regime and the role of different pseudo-potential profiles on the RA and NES phenomena. The RA/NES coexistence region brings an interesting interpretation for the growth kinetics of cancer cells population, as the NES effect enhancing the stability of the tumoral state becomes strongly reduced by the RA phenomenon.

q-bio.PE↗

arXiv2007

Co-occurrence of resonant activation and noise-enhanced stability in a model of cancer growth in the presence of immune response

We investigate a stochastic version of a simple enzymatic reaction which follows the generic Michaelis-Menten kinetics. At sufficiently high concentrations of reacting species, the molecular fluctuations can be approximated as a realization of a Brownian dynamics for which the model reaction kinetics takes on the form of a stochastic differential equation. After eliminating a fast kinetics, the model can be rephrased into a form of a one-dimensional overdamped Langevin equation. We discuss physical aspects of environmental noises acting in such a reduced system, pointing out the possibility of coexistence of dynamical regimes where noise-enhanced stability and resonant activation phenomena can be observed together.

q-bio.PE↗

arXiv2006

Levy--Brownian motion on finite intervals: Mean first passage time analysis

We present the analysis of the first passage time problem on a finite interval for the generalized Wiener process that is driven by Lévy stable noises. The complexity of the first passage time statistics (mean first passage time, cumulative first passage time distribution) is elucidated together with a discussion of the proper setup of corresponding boundary conditions that correctly yield the statistics of first passages for these non-Gaussian noises. The validity of the method is tested numerically and compared against analytical formulae when the stability index $α$ approaches 2, recovering in this limit the standard results for the Fokker-Planck dynamics driven by Gaussian white noise.

cond-mat.stat-mech↗

arXiv2000

Compound Poisson Statistics and Models of Clustering of Radiation Induced DNA Double Strand Breaks

According to the experimental evidence damage induced by densely ionizing radiation in mammalian cells is distributed along the DNA molecule in the form of clusters. The most critical constituent of DNA damage are double-strand breaks (DSBs) which are formed when the breaks occur in both DNA strands and are directly opposite or separated by only a few base pairs. The paper discusses a model of clustered DSB formation viewed in terms of compound Poisson process along with the predictive assay of the formalism in application to experimental data.

physics.bio-ph↗