arXiv subjects

E. Sharifi

Publications and source records attributed to E. Sharifi.

3 recordsLinked to original sources

arXiv2026

Drug-delivery Ca-Mg silicate scaffolds encapsulated in PLGA

The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca7MgSi4O16) porous scaffolds were fabricated by a foam replica method, loaded with vancomycin hydrochloride and encapsulated in poly lactic-co-glycolic acid (PLGA) coatings. Field emission scanning electron microscopy, Archimedes porosimetry and Fourier-transform infrared spectroscopy were used to characterize the structure of the scaffolds. The drug delivery kinetics and cytocompatibility of the prepared scaffolds were also studied in vitro. The bare sample exhibited a burst release of vancomycin and low biocompatibility with respect to dental pulp stem cells based on the MTT assay due to the fast bioresorption of bredigite. While keeping the desirable characteristics of pores for tissue engineering, the biodegradable PLGA coatings modified the drug release kinetics, buffered physiological pH and hence improved the cell viability of the vancomycin-loaded scaffolds considerably.

physics.bio-ph↗

arXiv2026

Controlled drug delivery from chitosan-coated heparin-loaded nanopores anodically grown on nitinol shape-memory alloy

Nitinol (NiTi shape-memory alloy) is an interesting candidate in various medical applications like dental, orthopedic, and cardiovascular devices, owing to its unique mechanical behaviors and proper biocompatibility. The aim of this work is the local controlled delivery of a cardiovascular drug, heparin, loaded onto nitinol treated by electrochemical anodizing and chitosan coating. In this regard, the structure, wettability, drug release kinetics, and cell cytocompatibility of the specimens were analyzed in vitro. The two-stage anodizing process successfully developed a regular nanoporous layer of Ni-Ti-O on nitinol, which considerably decreased the sessile water contact angle and induced hydrophilicity. The application of the chitosan coatings controlled the release of heparin mainly by a diffusional mechanism, where the drug release mechanisms were evaluated by the Higuchi, first-order, zero-order, and Korsmeyer-Pepass models. Human umbilical cord endothelial cells (HUVECs) viability assay also showed the non-cytotoxicity of the samples, so that the best performance was found for the chitosan-coated samples. It is concluded that the designed drug delivery systems are promising for cardiovascular, particularly stent applications.

physics.bio-ph↗

arXiv2025

Fluoride doping into SiO2-MgO-CaO bioactive glass nanoparticles: bioactivity, biodegradation and biocompatibility assessments

In this research, for the first time, the structure, bioactivity, biodegradation and biocompatibility of SiO2-MgO-CaO glasses doped with different levels of fluoride were studied. The glassy powder samples were synthesized by a coprecipitation method followed by calcination at 500 C, where amorphicity and fluoride incorporation were verified by X-ray diffraction and Raman spectroscopy, respectively. The in vitro biomineralization and biodegradation of the samples were also investigated by electron microscopy, Raman spectroscopy and inductively coupled plasma optical emission spectrometry. These assessments revealed that there is an optimum level of fluoride doping to meet the highest bioactivity. Remarkably, the same level of incorporation presented the foremost biocompatibility with respect to osteoblast-like MG-63 human cells, as realized by the MTT assay and cell attachment studies.

cond-mat.mtrl-sci↗