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E. W. Lang

Publications and source records attributed to E. W. Lang.

3 recordsLinked to original sources

Brain Tumor Segmentation with Special Emphasis on the Non-Enhancing Brain Tumor Compartment

A U-Net based deep learning architecture is designed to segment brain tumors as they appear on various MRI modalities. Special emphasis is lent to the non-enhancing tumor compartment. The latter has not been considered anymore in recent brain tumor segmentation challenges like the MICCAI challenges. However, it is considered to be indicative of the survival time of the patient as well as of areas of further tumor growth. Hence it deems essential to have means to automatically delineate its extension within the tumor.

cs.CV

Robust Computational Extraction of Non-Enhancing Hypercellular Tumor Regions from Clinical Imaging Data

Accurate identification of non-enhancing hypercellular (NEH) tumor regions is an unmet need in neuro-oncological imaging, with significant implications for patient management and treatment planning. We present a robust computational framework that generates probability maps of NEH regions from routine MRI data, leveraging multiple network architectures to address the inherent variability and lack of clear imaging boundaries. Our approach was validated against independent clinical markers -- relative cerebral blood volume (rCBV) and enhancing tumor recurrence location (ETRL) -- demonstrating both methodological robustness and biological relevance. This framework enables reliable, non-invasive mapping of NEH tumor compartments, supporting their integration as imaging biomarkers in clinical workflows and advancing precision oncology for brain tumor patients.

cs.LG

On the use of Singular Spectrum Analysis

Singular Spectrum Analysis (SSA) or Singular Value Decomposition (SVD) are often used to de-noise univariate time series or to study their spectral profile. Both techniques rely on the eigendecomposition of the cor- relation matrix estimated after embedding the signal into its delayed coordi- nates. In this work we show that the eigenvectors can be used to calculate the coefficients of a set of filters which form a filter bank. The properties of these filters are derived. In particular we show that their outputs can be grouped according to their frequency response. Furthermore, the fre- quency at the maximum of each frequency response and the corresponding eigenvalue can provide a power spectrum estimation of the time series. Two different applications illustrate how both characteristics can be applied to analyze wideband signals in order to achieve narrow-band signals or to infer their frequency occupation.

eess.SP