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Eberhard Bodenschatz

Publications and source records attributed to Eberhard Bodenschatz.

At least 19 recordsLinked to original sources

A Multipurpose Thermal Convection Setup to Study Turbulent Super Structures

A thermal convection apparatus has been designed to study turbulent super structures at high Rayleigh numbers and Prandtl numbers of the order of unity. This apparatus consists of a rectangular cell with a length of $3.50\,\mathrm{m}$, width of $0.35\,\mathrm{m}$, and variable height, which is fixed at $0.70\,\mathrm{m}$ for the present study. This cell is installed inside a $5.6\,\mathrm{m}$ long pressure vessel facility, known as \emph{Göttingen Uboot}, which can be filled with compressed gasses (air, helium, nitrogen, or sulfur hexafluoride) at pressures up to $19\,\mathrm{bar}$, enabling Rayleigh numbers up to $ Ra \leq 5\times 10^{12}$ and Prandtl numbers of approximately $0.7 \leq Pr \leq 0.9$. The convection cell is bounded vertically by top and bottom plates consisting of a three-layer composite structure in which a thin Lexan plate is sandwiched between highly conductive aluminum plates. This allows for spatially resolved heat flux measurements. Each plate is subdivided into four longitudinal segments that can be independently temperature-controlled to enable homogeneous temperatures and the imposition of horizontal temperature gradients at both the top and bottom boundaries. While the bottom plate is electrically heated, the top plate's temperature is regulated using temperature-controlled circulating pressurized water. The apparatus is well suited for precise heat flux measurements, with the results obtained being in good agreement with those previously reported in the literature.

physics.flu-dyn

On the repeatability of turbulence

Turbulence has strong and seemingly random fluctuations. Assessing its repeatability is key to predicting flows in technology and nature, much of which decay as viscosity dissipates energy. Much has been done to this end since the work of Lorenz, but mostly in theory and simulations. Here we present experimental results from the Max Planck Variable Density Turbulence Tunnel where we generated decaying turbulence using an active grid, repeating the process with nominally identical initial conditions up to 30,000 times. In contrast with the case of stationary turbulence we found that the energy-carrying large scales show significant repeatability, irrespective of flow development time and turbulence strength. Small scales, however, can effectively be modeled by independent random variables, supporting current numerical approaches in which they are parametrised.

physics.flu-dyn

FLASHμ: Fast Localizing And Sizing of Holographic Microparticles

Reconstructing the 3D location and size of microparticles from diffraction images - holograms - is a computationally expensive inverse problem that has traditionally been solved using physics-based reconstruction methods. More recently, researchers have used machine learning methods to speed up the process. However, for small particles in large sample volumes the performance of these methods falls short of standard physics-based reconstruction methods. Here we designed a two-stage neural network architecture, FLASH$μ$, to detect small particles (6-100$μ$m) from holograms with large sample depths up to 20cm. Trained only on synthetic data with added physical noise, our method reliably detects particles of at least 9$μ$m diameter in real holograms, comparable to the standard reconstruction-based approaches while operating on smaller crops, at quarter of the original resolution and providing roughly a 600-fold speedup. In addition to introducing a novel approach to a non-local object detection or signal demixing problem, our work could enable low-cost, real-time holographic imaging setups.

cs.CV

Highly Localised Droplet Clustering in Shallow Cumulus Clouds

The growth, lifetime, number density, and size of water droplets in warm atmospheric clouds determine the evolution, lifetime and light transmission properties of those clouds. These small-scale cloud properties, in addition to precipitation initiation, have strong implications for the Earth's energy budget since warm clouds cover large geographic areas. Spatio-temporal correlations on the millimetre scale and smaller may or may not affect these properties of clouds. To date, the pioneering measurements of such correlations in marine stratocumulus clouds have relied on averaging over holographically reconstructed volumes spanning at least ten kilometres. These have revealed weak but widespread spatial clustering of cloud droplets. Here we present results of strong localised clustering on scales of half a metre or less from holographic measurements collected with the Max Planck CloudKite in shallow cumulus clouds in the mid-Atlantic trade wind region near Barbados, with a spatial separation of only 12~cm between measurement volumes. This observation challenges the foundations of our understanding of cloud microphysics at the droplet scale, with implications for cloud modelling in weather and climate prediction.

physics.ao-ph

Flat Cell Imaging

Recent advances in optical technology have significantly enhanced the resolution of imaging of living cells, achieving nanometer-scale precision. However, the crowded three-dimensional environment within cells presents a challenge for measuring the spatio-temporal dynamics of cellular components. One solution to this issue is expansion microscopy, which cannot be used for living cells. Here, we present a method for flattening live cells to a thickness of down to 200 nanometers by confining them between two surface-treated transparent plates. The anti-fouling coating on the surfaces restricts the cells to a quasi-two-dimensional space by exerting osmotic control and preventing surface adhesion. This technique increases the distance between cellular components, thereby enabling high-resolution imaging of their spatio-temporal dynamics. The viability and phenotype of various cell types are demonstrated to be unaltered upon release from flat-cell confinement. The flat cell imaging method is a robust and straightforward technique, making it a practical choice for optical microscopy.

physics.optics

Lagrangian Particle Tracking at Large Reynolds Numbers

Particle tracking in turbulent flows is fundamental to the study of the transport of tracers, inertial particles or even active objects in space and time, i.e. the Lagrangian frame of reference. It provides experimental tests of theoretical predictions (e.g. for the statistics of fluid accelerations and particle dispersion) and helps to understand important natural processes where particle inertia is important (e.g. cloud microphysics). While the spatial (Eulerian) properties of turbulent flows have been studied for high, atmospheric Reynolds numbers ($R_λ> 10^4$), the profound difficulties in accurately tracking particles in turbulent flows have limited the Reynolds numbers in the Lagrangian reference frame to the Taylor scale Reynolds numbers $R_λ\lesssim 10^3$. Here we describe a setup that allowed Lagrangian particle tracking at $R_λ$ between 100 and 6000 in the Max Planck Variable Density Turbulence Tunnel (VDTT). We describe the imaging setup within the pressurised facility, the laser illumination, the particles and the particle dispersion mechanism. We verify that the KOBO Cellulobeads D-10 particles are suitable tracers. They carry negligible charge and their Stokes number is small over the full range of experimental conditions. We present typical data from the experiment and discuss the challenges and constraints of the setup.

physics.flu-dyn

Sonogenetics is a novel antiarrhythmic treatment

Arrhythmia of the heart is a dangerous and potentially fatal condition. The current widely used treatment is the implantable cardioverter defibrillator (ICD), but it is invasive and affects the patient's quality of life. The sonogenetic treatment technique proposed here focuses transthoracic ultrasound on the heart, noninvasively stimulates endogenous stretch-activated Piezo1 ion channels on the focal region's cardiomyocyte plasma membrane, and restores normal heart rhythm. In contrast to anchoring the implanted ICD lead at a fixed position in the myocardium, the size and position of the ultrasound focal region can be selected dynamically by adjusting the signal phases of every piezoelectric chip on the wearable ultrasonic phased array, and it allows novel and efficient defibrillations. Based on the developed interdisciplinary electromechanical model of sonogenetic treatment, our analysis shows that the proposed ultrasound intensity and frequency will be safe and painless for humans and well below the limits established by the U.S. Food and Drug Administration.

physics.med-ph

A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge

Cells often migrate on curved surfaces inside the body, such as curved tissues, blood vessels or highly curved protrusions of other cells. Recent \textit{in-vitro} experiments provide clear evidence that motile cells are affected by the curvature of the substrate on which they migrate, preferring certain curvatures to others, termed ``curvotaxis". The origin and underlying mechanism that gives rise to this curvature sensitivity are not well understood. Here, we employ a ``minimal cell" model which is composed of a vesicle that contains curved membrane protein complexes, that exert protrusive forces on the membrane (representing the pressure due to actin polymerization). This minimal-cell model gives rise to spontaneous emergence of a motile phenotype, driven by a lamellipodia-like leading edge. By systematically screening the behaviour of this model on different types of curved substrates (sinusoidal, cylinder and tube), we show that minimal ingredients and energy terms capture the experimental data. The model recovers the observed migration on the sinusoidal substrate, where cells move along the grooves (minima), while avoiding motion along the ridges. In addition, the model predicts the tendency of cells to migrate circumferentially on convex substrates and axially on concave ones. Both of these predictions are verified experimentally, on several cell types. Altogether, our results identify the minimization of membrane-substrate adhesion energy and binding energy between the membrane protein complexes as key players of curvotaxis in cell migration.

physics.bio-ph

Physical model of end-diastolic and end-systolic pressure-volume relationships of a heart

Left ventricular (LV) stiffness and contractility, characterized by the end-diastolic and end-systolic pressure-volume relationships (EDPVR & ESPVR), are two important indicators of the performance of the human heart. Although much research has been conducted on EDPVR and ESPVR, no model with physically interpretable parameters combining both relationships has been presented, thereby impairing the understanding of cardiac physiology and pathology. Here, we present a model that evaluates both EDPVR and ESPVR with physical interpretations of the parameters in a unified framework. Our physics-based model fits the available experimental data and in silico results very well and outperforms existing models. With prescribed parameters, the new model is used to predict the pressure-volume relationships of the left ventricle. Our model provides a deeper understanding of cardiac mechanics and thus will have applications in cardiac research and clinical medicine.

physics.med-ph

Flight of a honeybee in turbulent wind

In windy conditions, the air is turbulent. The strong and intermittent velocity variations of turbulence are invisible to flying animals. Nevertheless, flying animals, not much larger than the smallest scales of turbulence, manage to maneuver these highly fluctuating conditions quite well. Here we quantify honeybee flight with time-resolved three-dimensional tracking in calm conditions and controlled turbulent winds. We find that honeybee mean speed and acceleration are only weakly correlated with the strength of turbulence. In flight, honeybees accelerate slowly and decelerate rapidly, i.e., they break suddenly during turns and then accelerate again. While this behavior is observed in both calm and turbulent conditions, it is increasingly dominant under turbulent conditions where short straight trajectories are broken by turns and increased maneuvering. This flight-crash behavior is reminiscent of turbulence itself. Our observations may help the development of flight strategies for miniature flying robotics under turbulent conditions.

physics.flu-dyn

Experimental measurement of respiratory particles dispersed by wind instruments and analysis of the associated risk of infection transmission

Activities such as singing or playing a wind instrument release respiratory particles into the air that may contain pathogens and thus pose a risk for infection transmission. Here we report measurements of the size distribution, number, and volume concentration of exhaled particles from 31 healthy musicians playing 20 types of wind instruments using aerosol spectrometry and in-line holography in a strictly controlled cleanroom environment. We find that playing wind instruments carries a lower risk of airborne disease transmission than speaking or singing. We attribute this to the fact that the resonators of wind instruments act as filters for particles >10 $μ$m in diameter. We have also measured the size-dependent filtering properties of different types of filters that can be used as instrument masks. Based on these measurements, we calculated the risk of airborne transmission of SARS-CoV-2 in different near- and far-field scenarios with and without masking and/or distancing. We conclude that in all cases where there is a possibility that the musician is infectious, the only safe measure to prevent airborne transmission of the disease is the use of well-fitting and well-filtering masks for the instrument and the susceptible person.

physics.med-ph

Scaling in Decaying Turbulence at High Reynolds Numbers

The way the increment statistics of turbulent velocity fluctuations scale with the increment size is a centerpiece of turbulence theories. We report data on decaying turbulence in the Max Planck Variable Density Turbulence Tunnel (VDTT), which show an approach of the inertial range statistics toward a nontrivial shape at small scales. By correcting for the contributions of energy decay to the large-scale statistics with a model, we find the scaling exponent of the second-order velocity increment statistics to be independent of the Reynolds number and equal to $0.693\pm0.003$ for $2000\lesssim R_λ \lesssim 6000$. This is evidence of a universal inertial range at high Reynolds numbers.

physics.flu-dyn

On the risk of infection by infectious aerosols in large indoor spaces

Airborne diseases can be transmitted by infectious aerosols in the near field, i.e., in close proximity, or in the far field, i.e., by infectious aerosols that are well mixed within the indoor air. Is it possible to say which mode of disease transmission is predominant in large indoor spaces? We addressed this question by measuring the transport of aerosols equivalent to the size of human respiratory particles in two large hardware stores (V>10000 m$^3$). We found that aerosol concentrations in both stores decreased rapidly and almost independently of aerosol size, despite the different ventilation systems. A persistent and directional airflow on the order of a few cm/s was observed in both stores. Consequently, aerosol dynamics in such open settings can be expected to be dominated by turbulent dispersion and sweeping, and the accumulation of infectious aerosols in the indoor air is unlikely to contribute significantly to the risk of infection as long as the occupancy of the store is not too high. Under these conditions, well-fitting face masks are an excellent means of preventing disease transmission by human aerosols.

q-bio.PE

Universality in Decaying Turbulence at High Reynolds Numbers

A hallmark of fluid turbulence theory is the universal power law scaling of the velocity difference statistics between two points in space in the inertial range between the large energy injection scale and the small energy dissipation scale. Even at the highest Reynolds numbers available, laboratory and natural flows such universal power laws have not been convincingly demonstrated. Here we show for the decaying active grid turbulence of the Max Planck Variable Density Turbulence Tunnel that the velocity difference statistics at high Reynolds numbers do not exhibit a power law, but have a universal functional form independent of the Reynolds number. We separate this functional form from the power law exponent and discuss potential consequences for turbulence modelling.

physics.flu-dyn

Nachhaltige Strategien gegen die COVID-19-Pandemie in Deutschland im Winter 2021/2022

In this position paper, a large group of interdisciplinary experts outlines response strategies against the spread of SARS-CoV-2 in the winter of 2021/2022 in Germany. We review the current state of the COVID-19 pandemic, from incidence and vaccination efficacy to hospital capacity. Building on this situation assessment, we illustrate various possible scenarios for the winter, and detail the mechanisms and effectiveness of the non-pharmaceutical interventions, vaccination, and booster. With this assessment, we want to provide orientation for decision makers about the progress and mitigation of COVID-19.

q-bio.OT

Respiratory aerosols and droplets in the transmission of infectious diseases

Knowing the physicochemical properties of exhaled droplets and aerosol particles is a prerequisite for a detailed mechanistic understanding and effective prevention of the airborne transmission of infectious human diseases. This article provides a critical review and synthesis of scientific knowledge on the number concentrations, size distributions, composition, mixing state, and related properties of respiratory particles emitted upon breathing, speaking, singing, coughing, and sneezing. We derive and present a parameterization of respiratory particle size distributions based on five lognormal modes related to different origins in the respiratory tract, which can be used to trace and localize the sources of infectious particles. This approach may support the medical treatment as well as the risk assessment for aerosol and droplet transmission of infectious diseases. It was applied to analyze which respiratory activities may drive the spread of specific pathogens, such as Mycobacterium tuberculosis, influenza viruses, and SARS-CoV-2 viruses. The results confirm the high relevance of vocalization for the transmission of SARS-CoV-2 as well as the usefulness of physical distancing, face masks, room ventilation, and air filtration as preventive measures against COVID-19 and other airborne infectious diseases.

physics.med-ph

Generation of intense dissipation in high Reynolds number turbulence

Intense fluctuations of energy dissipation rate in turbulent flows result from the self-amplification of strain rate via a quadratic nonlinearity, with contributions from vorticity (via the vortex stretching mechanism) and the pressure Hessian tensor, which we analyze here using direct numerical simulations of isotropic turbulence in periodic domains of up to $12288^3$ grid points, and Taylor-scale Reynolds numbers in the range $140-1300$. We extract the statistics of various terms involved in amplification of strain and additionally condition them on the magnitude of strain. We find that strain is overall self-amplified by the quadratic nonlinearity, and depleted via vortex stretching; whereas pressure Hessian acts to redistribute strain fluctuations towards the mean-field and thus depleting intense strain. Analyzing the intense fluctuations of strain in terms of its eigenvalues reveals that the net amplification is solely produced by the third eigenvalue, resulting in strong compressive action. In contrast, the self-amplification terms acts to deplete the other two eigenvalues, whereas vortex stretching acts to amplify them, both effects canceling each other almost perfectly. The effect of the pressure Hessian for each eigenvalue is qualitatively similar to that of vortex stretching, but significantly weaker in magnitude. Our results conform with the familiar notion that intense strain is organized in sheet-like structures, which are in the vicinity of, but never overlap with regions of intense vorticity due to fundamental differences in their amplifying mechanisms.

physics.flu-dyn

Face-masks save us from SARS-CoV-2 transmission

We present results on the infection risk from SARS-CoV-2 under different scenarios based on measured particle size-dependent mask penetration, measured total inward leakage, measured human aerosol emission for sizes from 10nm to 1mm, and re-hydration on inhalation. Well-mixed room models significantly underestimate the risk of infection for short and direct exposure. To this end, we estimate the upper bound for infection risk with the susceptible in the infectious exhalation cloud or wearing masks by having the masked susceptible inhale the entire exhalation of a masked infectious. Social distances without a mask, even at 3m between speaking individuals results in an upper bound of 90\% for risk of infection after a few minutes. If both wear a surgical mask, the risk of infection for the person speaking remains below 26\% even after 60 minutes. When both the infectious and susceptible wear a well-fitting FFP2 mask, the upper bound for risk is reduced by a factor of 60 compared to surgical masks. In both cases, face leakage is very important. For FFP2 masks, leakage is low in the nasal region and directed upward, which can be further reduced significantly by applying double-sided medical tape there. Considering that the calculated upper bound greatly overestimates the risk of infection, and the fact that with a poorly worn mask even the upper bound we calculated is very low, we conclude that wearing a mask, even with some leakage, provides excellent third party and self-protection.

physics.med-ph