arXiv subjects

Edward L Boone

Publications and source records attributed to Edward L Boone.

3 recordsLinked to original sources

arXiv2022

Incorporating Interventions to an Extended SEIRD Model with Vaccination: Application to COVID-19 in Qatar

The Covid-19 outbreak of 2020 has required many governments to develop and adopt mathematical-statistical models of the pandemic for policy and planning purposes. To this end, this work provides a tutorial on building a compartmental model using Susceptible, Exposed, Infected, Recovered, Deaths and Vaccinated (SEIRDV) status through time. The proposed model uses interventions to quantify the impact of various government attempts made to slow the spread of the virus. Furthermore, a vaccination parameter is also incorporated in the model, which is inactive until the time the vaccine is deployed. A Bayesian framework is utilized to perform both parameter estimation and prediction. Predictions are made to determine when the peak Active Infections occur. We provide inferential frameworks for assessing the effects of government interventions on the dynamic progression of the pandemic, including the impact of vaccination. The proposed model also allows for quantification of number of excess deaths averted over the study period due to vaccination.

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arXiv2020

Application of Bayesian Dynamic Linear Models to Random Allocation Clinical Trials

Random allocation models used in clinical trials aid researchers in determining which of a particular treatment provides the best results by reducing bias between groups. Often however, this determination leaves researchers battling ethical issues of providing patients with unfavorable treatments. Many methods such as Play the Winner and Randomized Play the Winner Rule have historically been utilized to determine patient allocation, however, these methods are prone to the increased assignment of unfavorable treatments. Recently a new Bayesian Method using Decreasingly Informative Priors has been proposed by \citep{sabo2014adaptive}, and later \citep{donahue2020allocation}. Yet this method can be time consuming if MCMC methods are required. We propose the use of a new method which uses Dynamic Linear Model (DLM) \citep{harrison1999bayesian} to increase allocation speed while also decreasing patient allocation samples necessary to identify the more favorable treatment. Furthermore, a sensitivity analysis is conducted on multiple parameters. Finally, a Bayes Factor is calculated to determine the proportion of unused patient budget remaining at a specified cut off and this will be used to determine decisive evidence in favor of the better treatment.

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arXiv2017

A Bayesian Estimation for the Fractional Order of the Differential Equation that Models Transport in Unconventional Hydrocarbon Reservoirs

The extraction of natural gas from the earth has been shown to be governed by differential equations concerning flow through a porous material. Recently, models such as fractional differential equations have been developed to model this phenomenon. One key issue with these models is estimating the fraction of the differential equation. Traditional methods such as maximum likelihood, least squares and even method of moments are not available to estimate this parameter as traditional calculus methods do not apply. We develop a Bayesian approach to estimate the fraction of the order of the differential equation that models transport in unconventional hydrocarbon reservoirs. In this paper, we use this approach to adequately quantify the uncertainties associated with the error and predictions. A simulation study is presented as well to assess the utility of the modeling approach.

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