arXiv subjects

Edwin Versteeg

Publications and source records attributed to Edwin Versteeg.

7 recordsLinked to original sources

arXiv2026

Bilateral breast gradient insert prototype for strong diffusion encoding at 3T

Purpose: Diffusion MRI has shown promise for breast cancer screening, lesion characterization,and treatment response monitoring without contrast agents, but further translation is constraint by the gradient performance of conventional systems. The aim of this work is to develop a single-axis high performance bilateral plug-and-play breast gradient insert to enable strong-gradient diffusion MRI. Methods: An in-house breast gradient insert and bed-tabletop was constructed entirely from commercially available materials, providing a cost-effective solution compatible with existing MRI systems. Its wiring pattern was optimized for torque and force balancing, power dissipation, and target field performance. Evaluation included gradient field characterization, peripheral nerve stimulation simulation verification, and temperature and eddy current assessment. The setup was used for imaging of a diffusion phantom based on soy lecithin across a range of b-values. Results: Gradient efficiency reached 2.8 mT/m/A, enabling local strengths up to 1850 mT/m (660 A). No peripheral nerve stimulation was observed during tests on five healthy volunteers. Eddy currents were successfully characterized employed in standard correction methods. Imaging showed the feasibility of $b = 10 000 s/mm^2$ acquisitions at TE = 78 ms versus 161 ms with scanner gradients. Conclusion: This work demonstrates a dedicated bilateral breast gradient insert for safe and feasible strong-gradient breast diffusion MRI, and represents a first step toward dedicated hardware for breast cancer detection and characterization without contrast agents.

physics.med-ph↗

arXiv2026

Design of a double breast gradient coil with controlled anterior posterior gradient variation for diffusion weighted imaging

Introduction High performance gradients poses a promise for breast diffusion weighted imaging (DWI) but are restricted by physiological limits in whole body scanners. While local nonlinear coils offer higher amplitudes, they often suffer from severe gradient reduction near the chest wall. Methods We introduced an optimization framework incorporating a constraint to control anterior posterior gradient variation. A width based figure of merit was defined to evaluate performance regarding coil efficiency and minimum wire width. A prototype was constructed to validate the design methodology. Results The optimized coil achieved a 2.35 fold efficiency increase over standard linear coils. Compared to previous nonlinear designs, the new constraint reduced spatial variation by 35.7% and improved minimum efficiency near the chest wall by 2.6 fold. Experimental field maps matched simulations with errors under 8%. Discussion The proposed method effectively mitigates the trade-off between gradient strength and spatial uniformity along anterior posterior direction. By enhancing performance in the posterior breast region, the design addresses a critical limitation of previous local coils. Conclusion This framework enables the development of high performance, robust local gradient coils, facilitating the clinical implementation of advanced DWI protocols for breast cancer screening.

physics.med-ph↗

arXiv2026

Feasibility of Continuous Ventricular Volumetric Quantification in Arrhythmias using Real-Time 3D CMR-MOTUS

Conventional cardiovascular magnetic resonance (CMR) cine imaging combines data across multiple heartbeats, an assumption that can fail in arrhythmia because beat-to-beat variation causes motion artifacts and obscures functional heterogeneity. Although 2D real-time cine resolves individual beats, stacked slices are suboptimal for capturing complex 3D cardiac dynamics. We investigated continuous beat-to-beat volumetric quantification in patients with premature ventricular contractions (PVCs) using free-running 3D real-time CMR. CMR-MOTUS was extended to jointly reconstruct time-resolved 3D motion fields and a motion-corrected reference image from continuously acquired data without breath-holding or ECG gating. Data were acquired with a variable-density Cartesian trajectory and either 3D spoiled gradient-echo or balanced steady-state free-precession imaging. Ventricular volumes were obtained by propagating one manual reference-image segmentation through all reconstructed frames. The method was evaluated in a cardiac motion phantom with static ground-truth acquisitions, 10 healthy volunteers, and 10 patients with PVCs; all in vivo scans were performed after contrast administration. Phantom ejection fraction (EF) agreed closely with ground truth (17.86% versus 17.27%). Healthy volunteers showed narrow beat-to-beat EF distributions, whereas patients with PVCs showed broader and sometimes bimodal distributions. Simultaneous ECG recordings supported the temporal correspondence between volume irregularities and PVC episodes. Free-running joint 3D motion-field and image reconstruction enables continuous beat-to-beat volumetric assessment and can reveal functional heterogeneity obscured by gated or heartbeat-averaged methods. Larger studies are required to establish clinical validity and determine its role alongside standard 2D cine analysis.

physics.med-ph↗

arXiv2025

Implicit neural representations for accurate estimation of the standard model of white matter

Diffusion magnetic resonance imaging (dMRI) enables non-invasive investigation of tissue microstructure. The Standard Model (SM) of white matter aims to disentangle dMRI signal contributions from intra- and extra-axonal water compartments. However, due to the model its high-dimensional nature, accurately estimating its parameters poses a complex problem and remains an active field of research, in which different (machine learning) strategies have been proposed. This work introduces an estimation framework based on implicit neural representations (INRs), which incorporate spatial regularization through the sinusoidal encoding of the input coordinates. The INR method is evaluated on both synthetic and in vivo datasets and compared to existing methods. Results demonstrate superior accuracy of the INR method in estimating SM parameters, particularly in low signal-to-noise conditions. Additionally, spatial upsampling of the INR can represent the underlying dataset anatomically plausibly in a continuous way. The INR is self-supervised, eliminating the need for labeled training data. It achieves fast inference, is robust to noise, supports joint estimation of SM kernel parameters and the fiber orientation distribution function with spherical harmonics orders up to at least 8, and accommodates gradient non-uniformity corrections. The combination of these properties positions INRs as a potentially important tool for analyzing and interpreting diffusion MRI data.

eess.IV↗

arXiv2024

Time-efficient, high-resolution 3T whole-brain relaxometry using Cartesian 3D MR-STAT with CSF suppression

Purpose: Current 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocols use transient-state, gradient-spoiled gradient-echo sequences that are prone to cerebrospinal fluid (CSF) pulsation artifacts when applied to the brain. This study aims at developing a 3D MR-STAT protocol for whole-brain relaxometry that overcomes the challenges posed by CSF-induced ghosting artifacts. Method: We optimized the flip-angle train within the Cartesian 3D MR-STAT framework to achieve two objectives: (1) minimization of the noise level in the reconstructed quantitative maps, and (2) reduction of the CSF-to-white-matter signal ratio to suppress CSF signal and the associated pulsation artifacts. The optimized new sequence was tested on a gel/water-phantom to evaluate the accuracy of the quantitative maps, and on healthy volunteers to explore the effectiveness of the CSF artifact suppression and robustness of the new protocol. Results: A new optimized sequence with both high parameter encoding capability and low CSF intensity was proposed and initially validated in the gel/water-phantom experiment. From in-vivo experiments with five volunteers, the proposed CSF-suppressed sequence shows no CSF ghosting artifacts and overall greatly improved image quality for all quantitative maps compared to the baseline sequence. Statistical analysis indicated low inter-subject and inter-scan variability for quantitative parameters in gray matter and white matter (1.6%-2.4% for T1 and 2.0%-4.6% for T2), demonstrating the robustness of the new sequence. Conclusion: We presented a new 3D MR-STAT sequence with CSF suppression that effectively eliminates CSF pulsation artifacts. The new sequence ensures consistently high-quality, 1mm^3 whole-brain relaxometry within a rapid 5.5-minute scan time.

physics.med-ph↗

arXiv2023

Open-source Pulseq sequences on Philips MRI scanners

Purpose: This work aims to address the limitations faced by researchers in developing and sharing new MRI sequences by implementing an interpreter for the open-source MRI pulse sequence format, Pulseq, on a Philips MRI scanner. Methods: The implementation involved modifying a few source code files to create a Pulseq interpreter for the Philips MRI system. Validation experiments were conducted using simulations and phantom scans performed on a 7T Achieva MRI system. The observed sequence and waveforms were compared to the intended ones, and the gradient waveforms produced by the scanner were verified using a field camera. Image reconstruction was performed using the raw k-space samples acquired from both the native vendor environment and the Pulseq interpreter. Results: The reconstructed images obtained through the Pulseq implementation were found to be comparable to those obtained through the native implementation. The performance of the Pulseq interpreter was assessed by profiling the CPU utilization of the MRI spectrometer, showing minimal resource utilization for certain sequences. Conclusion: The successful implementation of the Pulseq interpreter on the Philips MRI scanner demonstrates the feasibility of utilizing Pulseq sequences on Philips MRI scanners. This provides an open-source platform for MRI sequence development, facilitating collaboration among researchers and accelerating scientific progress in the field of MRI.

physics.med-ph↗

arXiv2023

A three-dimensional MR-STAT protocol for high-resolution multi-parametric quantitative MRI

Magnetic Resonance Spin Tomography in Time-Domain (MR-STAT) is a multiparametric quantitative MR framework, which allows for simultaneously acquiring quantitative tissue parameters such as T1, T2 and proton density from one single short scan. A typical 2D MR-STAT acquisition uses a gradient-spoiled, gradient-echo sequence with a slowly varying RF flip-angle train and Cartesian readouts, and the quantitative tissue maps are reconstructed by an iterative, model-based optimization algorithm. In this work, we design a 3D MR-STAT framework based on previous 2D work, in order to achieve better image SNR, higher though-plan resolution and better tissue characterization. Specifically, we design a 7-minute, high-resolution 3D MR-STAT sequence, and the corresponding two-step reconstruction algorithm for the large-scale dataset. To reduce the long acquisition time, Cartesian undersampling strategies such as SENSE are adopted in our transient-state quantitative framework. To reduce the computational burden, a data splitting scheme is designed for decoupling the 3D reconstruction problem into independent 2D reconstructions. The proposed 3D framework is validated by numerical simulations, phantom experiments and in-vivo experiments. High-quality knee quantitative maps with 0.8 x 0.8 x 1.5mm3 resolution and bilateral lower leg maps with 1.6mm isotropic resolution can be acquired using the proposed 7-minute acquisition sequence and the 3-minute-per-slice decoupled reconstruction algorithm. The proposed 3D MR-STAT framework could have wide clinical applications in the future.

physics.med-ph↗