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Elahe Vedadi

Publications and source records attributed to Elahe Vedadi.

14 recordsLinked to original sources

Extremal Chowla sets and their linear analogues: A human-AI mathematical investigation using Co-Scientist

We introduce an extremal invariant associated with Chowla-type order conditions in finite groups. A nonempty subset $S$ of a finite group $G$ is called a Chowla set if every element of $S$ has order greater than $|S|$, and we write $C(G)$ for the maximum cardinality of such a set. We first show that $C(G)$ is determined by the distribution of element orders in $G$. For cyclic groups, we derive an exact divisor formula and characterize the integers $n$ for which $C(\mathbb{Z}/n\mathbb{Z})=φ(n)$. We prove that $\liminf_{n\to\infty}C(\mathbb{Z}/n\mathbb{Z})/φ(n)=1$, whereas $\limsup_{n\to\infty}C(\mathbb{Z}/n\mathbb{Z})/φ(n)=\infty$, and we determine the corresponding lower and upper limits under normalization by $n$. For finite abelian groups, we obtain an explicit formula in terms of the invariant-factor decomposition, together with a closed formula for finite abelian $p$-groups. We then develop a linear analogue for finite field extensions. A nonzero $K$-subspace $A$ of an extension $L/K$ is called a Chowla subspace if $[K(a):K]>\dim_K A$ for every nonzero $a\in A$. Since this condition depends on $\dim_K A$, it does not generally require every nonzero element of $A$ to generate $L$ over $K$. Nevertheless, when $L/K$ is finite and separable, we prove the exact formula $C(L/K)=[L:K]-d_{\max}(L/K)$, where $d_{\max}(L/K)$ is the largest degree over $K$ of a proper intermediate field. For finite fields, we give a direct proof in every degree using a normal-basis construction. This work was developed through an expert-guided human-AI collaboration. A reasoning-focused configuration of Co-Scientist was used to explore examples and potential proof strategies. The authors formulated the problem, independently verified and completed all arguments, and wrote the final proofs.

math.NT

Accelerating scientific discovery with Co-Scientist

Scientific discovery is driven by scientists generating novel hypotheses for complex problems that undergo rigorous experimental validation. To augment this process, we introduce Co-Scientist, a multi-agent AI system built on Gemini for structured scientific thinking and hypothesis generation. Co-Scientist aims to help scientists discover new original knowledge. Conditioned on their research objectives and prior scientific evidence, it formulates demonstrably novel research hypotheses for experimental verification. The system's design involves agents continuously generating, critiquing and refining hypotheses accelerated by scaling test-time compute. Key contributions include: (1) a multi-agent architecture with an asynchronous task execution framework for flexible compute scaling; (2) a tournament evolution process for self-improving hypotheses generation. Automated evaluations show continued benefits of test-time compute scaling, improving hypothesis quality over time. While general purpose, we focus the validation in three biomedical applications: drug repurposing, novel target discovery, and explaining mechanisms of anti-microbial resistance. Specifically, Co-Scientist helped identify new drug repurposing candidates and synergistic combination therapies for acute myeloid leukemia, which were validated through in vitro experiments. These real-world validations demonstrate the potential of Co-Scientist to accelerate scientific discovery and usher in an era of AI empowered scientists.

cs.AI

An AI Co-Data-Scientist for Prioritizing Candidate Biomarkers from Wearable Sensor Data

Wearable devices generate continuous physiological and behavioral data, but converting these signals into clinically reviewable biomarker hypotheses remains labor-intensive. We introduce CoDaS, an AI co-data-scientist that integrates multi-agent hypothesis generation, deterministic statistical analysis, adversarial validation and literature-grounded interpretation under human oversight. Across three wearable cohorts comprising 9,279 participant-observations, CoDaS prioritized candidate associations for mental-health and metabolic endpoints after internal checks for replication, stability, robustness and leakage. The system identified related circadian-instability signals associated with depression, including sleep-duration variability in DWB ($ρ$ = 0.252, $p$ < 0.001) and sleep-onset variability in GLOBEM ($ρ$ = 0.126, $p$ < 0.001), and derived a wearable cardiovascular-fitness index associated with insulin resistance (steps/resting heart rate; $ρ$ = -0.374, $p$ < 0.001). Adding these features to demographic models produced modest gains ($ΔR^2$ = 0.040 for depression, 0.021 for insulin resistance). In a 12-clinician review totaling approximately 25 active hours, clinician validity judgments aligned with CoDaS confidence tiers ($ρ$ = 0.67, $p$ = 0.005), whereas added clinical value and confidence to act were rated lower. CoDaS supports traceable, hypothesis-generating prioritization of wearable candidate biomarkers.

cs.AI

A prospective clinical feasibility study of a conversational diagnostic AI in an ambulatory primary care clinic

Large language model (LLM)-based AI systems have shown promise for patient-facing diagnostic and management conversations in simulated settings. Translating these systems into clinical practice requires assessment in real-world workflows with rigorous safety oversight. We report a prospective, single-arm feasibility study of an LLM-based conversational AI, the Articulate Medical Intelligence Explorer (AMIE), conducting clinical history taking and presentation of potential diagnoses for patients to discuss with their provider at urgent care appointments at a leading academic medical center. 100 adult patients completed an AMIE text-chat interaction up to 5 days before their appointment. We sought to assess the conversational safety and quality, patient and clinician experience, and clinical reasoning capabilities compared to primary care providers (PCPs). Human safety supervisors monitored all patient-AMIE interactions in real time and did not need to intervene to stop any consultations based on pre-defined criteria. Patients reported high satisfaction and their attitudes towards AI improved after interacting with AMIE (p < 0.001). PCPs found AMIE's output useful with a positive impact on preparedness. AMIE's differential diagnosis (DDx) included the final diagnosis, per chart review 8 weeks post-encounter, in 90% of cases, with 75% top-3 accuracy. Blinded assessment of AMIE and PCP DDx and management (Mx) plans suggested similar overall DDx and Mx plan quality, without significant differences for DDx (p = 0.6) and appropriateness and safety of Mx (p = 0.1 and 1.0, respectively). PCPs outperformed AMIE in the practicality (p = 0.003) and cost effectiveness (p = 0.004) of Mx. While further research is needed, this study demonstrates the initial feasibility, safety, and user acceptance of conversational AI in a real-world setting, representing crucial steps towards clinical translation.

cs.HC

Complementary Human-AI Clinical Reasoning in Ophthalmology

Vision impairment and blindness are a major global health challenge where gaps in the ophthalmology workforce limit access to specialist care. We evaluate AMIE, a medically fine-tuned conversational system based on Gemini with integrated web search and self-critique reasoning, using real-world clinical vignettes that reflect scenarios a general ophthalmologist would be expected to manage. We conducted two complementary evaluations: (1) a human-AI interactive diagnostic reasoning study in which ophthalmologists recorded initial differentials and plans, then reviewed AMIE's structured output and revised their answers; and (2) a masked preference and quality study comparing AMIE's narrative outputs with case author reference answers using a predefined rubric. AMIE showed standalone diagnostic performance comparable to clinicians at baseline. Crucially, after reviewing AMIE's responses, ophthalmologists tended to rank the correct diagnosis higher, reached greater agreement with one another, and enriched their investigation and management plans. Improvements were observed even when AMIE's top choice differed from or underperformed the clinician baseline, consistent with a complementary effect in which structured reasoning support helps clinicians re-rank rather than simply accept the model output. Preferences varied by clinical grade, suggesting opportunities to personalise responses by experience. Without ophthalmology-specific fine-tuning, AMIE matched clinician baseline and augmented clinical reasoning at the point of need, motivating multi-axis evaluation, domain adaptation, and prospective multimodal studies in real-world settings.

cs.HC

Efficient and Privacy-Preserving Binary Dot Product via Multi-Party Computation

Striking a balance between protecting data privacy and enabling collaborative computation is a critical challenge for distributed machine learning. While privacy-preserving techniques for federated learning have been extensively developed, methods for scenarios involving bitwise operations, such as tree-based vertical federated learning (VFL), are still underexplored. Traditional mechanisms, including Shamir's secret sharing and multi-party computation (MPC), are not optimized for bitwise operations over binary data, particularly in settings where each participant holds a different part of the binary vector. This paper addresses the limitations of existing methods by proposing a novel binary multi-party computation (BiMPC) framework. The BiMPC mechanism facilitates privacy-preserving bitwise operations, with a particular focus on dot product computations of binary vectors, ensuring the privacy of each individual bit. The core of BiMPC is a novel approach called Dot Product via Modular Addition (DoMA), which uses regular and modular additions for efficient binary dot product calculation. To ensure privacy, BiMPC uses random masking in a higher field for linear computations and a three-party oblivious transfer (triot) protocol for non-linear binary operations. The privacy guarantees of the BiMPC framework are rigorously analyzed, demonstrating its efficiency and scalability in distributed settings.

cs.CR

Towards physician-centered oversight of conversational diagnostic AI

Recent work has demonstrated the promise of conversational AI systems for diagnostic dialogue. However, real-world assurance of patient safety means that providing individual diagnoses and treatment plans is considered a regulated activity by licensed professionals. Furthermore, physicians commonly oversee other team members in such activities, including nurse practitioners (NPs) or physician assistants/associates (PAs). Inspired by this, we propose a framework for effective, asynchronous oversight of the Articulate Medical Intelligence Explorer (AMIE) AI system. We propose guardrailed-AMIE (g-AMIE), a multi-agent system that performs history taking within guardrails, abstaining from individualized medical advice. Afterwards, g-AMIE conveys assessments to an overseeing primary care physician (PCP) in a clinician cockpit interface. The PCP provides oversight and retains accountability of the clinical decision. This effectively decouples oversight from intake and can thus happen asynchronously. In a randomized, blinded virtual Objective Structured Clinical Examination (OSCE) of text consultations with asynchronous oversight, we compared g-AMIE to NPs/PAs or a group of PCPs under the same guardrails. Across 60 scenarios, g-AMIE outperformed both groups in performing high-quality intake, summarizing cases, and proposing diagnoses and management plans for the overseeing PCP to review. This resulted in higher quality composite decisions. PCP oversight of g-AMIE was also more time-efficient than standalone PCP consultations in prior work. While our study does not replicate existing clinical practices and likely underestimates clinicians' capabilities, our results demonstrate the promise of asynchronous oversight as a feasible paradigm for diagnostic AI systems to operate under expert human oversight for enhancing real-world care.

cs.AI

Advancing Conversational Diagnostic AI with Multimodal Reasoning

Large Language Models (LLMs) have demonstrated great potential for conducting diagnostic conversations but evaluation has been largely limited to language-only interactions, deviating from the real-world requirements of remote care delivery. Instant messaging platforms permit clinicians and patients to upload and discuss multimodal medical artifacts seamlessly in medical consultation, but the ability of LLMs to reason over such data while preserving other attributes of competent diagnostic conversation remains unknown. Here we advance the conversational diagnosis and management performance of the Articulate Medical Intelligence Explorer (AMIE) through a new capability to gather and interpret multimodal data, and reason about this precisely during consultations. Leveraging Gemini 2.0 Flash, our system implements a state-aware dialogue framework, where conversation flow is dynamically controlled by intermediate model outputs reflecting patient states and evolving diagnoses. Follow-up questions are strategically directed by uncertainty in such patient states, leading to a more structured multimodal history-taking process that emulates experienced clinicians. We compared AMIE to primary care physicians (PCPs) in a randomized, blinded, OSCE-style study of chat-based consultations with patient actors. We constructed 105 evaluation scenarios using artifacts like smartphone skin photos, ECGs, and PDFs of clinical documents across diverse conditions and demographics. Our rubric assessed multimodal capabilities and other clinically meaningful axes like history-taking, diagnostic accuracy, management reasoning, communication, and empathy. Specialist evaluation showed AMIE to be superior to PCPs on 7/9 multimodal and 29/32 non-multimodal axes (including diagnostic accuracy). The results show clear progress in multimodal conversational diagnostic AI, but real-world translation needs further research.

cs.CL

Capabilities of Gemini Models in Medicine

Excellence in a wide variety of medical applications poses considerable challenges for AI, requiring advanced reasoning, access to up-to-date medical knowledge and understanding of complex multimodal data. Gemini models, with strong general capabilities in multimodal and long-context reasoning, offer exciting possibilities in medicine. Building on these core strengths of Gemini, we introduce Med-Gemini, a family of highly capable multimodal models that are specialized in medicine with the ability to seamlessly use web search, and that can be efficiently tailored to novel modalities using custom encoders. We evaluate Med-Gemini on 14 medical benchmarks, establishing new state-of-the-art (SoTA) performance on 10 of them, and surpass the GPT-4 model family on every benchmark where a direct comparison is viable, often by a wide margin. On the popular MedQA (USMLE) benchmark, our best-performing Med-Gemini model achieves SoTA performance of 91.1% accuracy, using a novel uncertainty-guided search strategy. On 7 multimodal benchmarks including NEJM Image Challenges and MMMU (health & medicine), Med-Gemini improves over GPT-4V by an average relative margin of 44.5%. We demonstrate the effectiveness of Med-Gemini's long-context capabilities through SoTA performance on a needle-in-a-haystack retrieval task from long de-identified health records and medical video question answering, surpassing prior bespoke methods using only in-context learning. Finally, Med-Gemini's performance suggests real-world utility by surpassing human experts on tasks such as medical text summarization, alongside demonstrations of promising potential for multimodal medical dialogue, medical research and education. Taken together, our results offer compelling evidence for Med-Gemini's potential, although further rigorous evaluation will be crucial before real-world deployment in this safety-critical domain.

cs.AI

Federated Variational Inference: Towards Improved Personalization and Generalization

Conventional federated learning algorithms train a single global model by leveraging all participating clients' data. However, due to heterogeneity in client generative distributions and predictive models, these approaches may not appropriately approximate the predictive process, converge to an optimal state, or generalize to new clients. We study personalization and generalization in stateless cross-device federated learning setups assuming heterogeneity in client data distributions and predictive models. We first propose a hierarchical generative model and formalize it using Bayesian Inference. We then approximate this process using Variational Inference to train our model efficiently. We call this algorithm Federated Variational Inference (FedVI). We use PAC-Bayes analysis to provide generalization bounds for FedVI. We evaluate our model on FEMNIST and CIFAR-100 image classification and show that FedVI beats the state-of-the-art on both tasks.

cs.LG

Efficient Coded Multi-Party Computation at Edge Networks

Multi-party computation (MPC) is promising for designing privacy-preserving machine learning algorithms at edge networks. An emerging approach is coded-MPC (CMPC), which advocates the use of coded computation to improve the performance of MPC in terms of the required number of workers involved in computations. The current approach for designing CMPC algorithms is to merely combine efficient coded computation constructions with MPC. We show that this approach fails short of being efficient; e.g., entangled polynomial codes are not necessarily better than PolyDot codes in MPC setting, while they are always better for coded computation. Motivated by this observation, we propose a new construction; Adaptive Gap Entangled (AGE) polynomial codes for MPC. We show through analysis and simulations that MPC with AGE codes always perform better than existing CMPC algorithms in terms of the required number of workers as well as computation, storage, and communication overhead.

cs.DC

PolyDot Coded Privacy Preserving Multi-Party Computation at the Edge

We investigate the problem of privacy preserving distributed matrix multiplication in edge networks using multi-party computation (MPC). Coded multi-party computation (CMPC) is an emerging approach to reduce the required number of workers in MPC by employing coded computation. Existing CMPC approaches usually combine coded computation algorithms designed for efficient matrix multiplication with MPC. We show that this approach is not efficient. We design a novel CMPC algorithm; PolyDot coded MPC (PolyDot-CMPC) by using a recently proposed coded computation algorithm; PolyDot codes. We exploit "garbage terms" that naturally arise when polynomials are constructed in the design of PolyDot-CMPC to reduce the number of workers needed for privacy-preserving computation. We show that entangled polynomial codes, which are consistently better than PolyDot codes in coded computation setup, are not necessarily better than PolyDot-CMPC in MPC setting.

cs.IT

Adaptive Gap Entangled Polynomial Coding for Multi-Party Computation at the Edge

Multi-party computation (MPC) is promising for designing privacy-preserving machine learning algorithms at edge networks. An emerging approach is coded-MPC (CMPC), which advocates the use of coded computation to improve the performance of MPC in terms of the required number of workers involved in computations. The current approach for designing CMPC algorithms is to merely combine efficient coded computation constructions with MPC. Instead, we propose a new construction; Adaptive Gap Entangled polynomial (AGE) codes, where the degrees of polynomials used in computations are optimized for MPC. We show that MPC with AGE codes (AGE-CMPC) performs better than existing CMPC algorithms in terms of the required number of workers as well as storage, communication and computation load.

cs.DC

Adaptive Coding for Matrix Multiplication at Edge Networks

Edge computing is emerging as a new paradigm to allow processing data at the edge of the network, where data is typically generated and collected, by exploiting multiple devices at the edge collectively. However, exploiting the potential of edge computing is challenging mainly due to the heterogeneous and time-varying nature of edge devices. Coded computation, which advocates mixing data in sub-tasks by employing erasure codes and offloading these sub-tasks to other devices for computation, is recently gaining interest, thanks to its higher reliability, smaller delay, and lower communication cost. In this paper, our focus is on characterizing the cost-benefit trade-offs of coded computation for practical edge computing systems, and develop an adaptive coded computation framework. In particular, we focus on matrix multiplication as a computationally intensive task, and develop an adaptive coding for matrix multiplication (ACM^2) algorithm by taking into account the heterogeneous and time varying nature of edge devices. ACM^2 dynamically selects the best coding policy by taking into account the computing time, storage requirements as well as successful decoding probability. We show that ACM^2 improves the task completion delay significantly as compared to existing coded matrix multiplication algorithms.

cs.IT