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Elisabeth Sommer James

Publications and source records attributed to Elisabeth Sommer James.

2 recordsLinked to original sources

Markov embedding of ranked unlabelled evolutionary trees and its applications

Rooted bifurcating trees are mathematical objects used to model evolutionary relationships and arise naturally in both coalescent theory and phylogenetics. Recent numerical representations of tree topologies, known as F-matrices, allow for summarizing a sample of trees via Fréchet means and provide new measures of tree balance. However, the number of ranked unlabelled trees grows super-exponentially with the number of leaves. This makes computation intensive and current methods rely on mixed integer programming and simulation-based methods. Moreover, F-matrices are difficult to interpret, and their distribution is only described in terms of first- and second-order moments under neutral branching. In this paper, we introduce a Markov chain embedding of ranked and unlabelled trees that drastically decreases the size of the state space. Leveraging this embedding, we develop an algorithm that efficiently computes all Fréchet means and use discrete phase-type theory to obtain the joint distribution of tree balance indices. We also use discrete phase-type theory to generalize previous results regarding moments of F-matrices to arbitrary order for any time homogeneous and bifurcating coalescent model. Using this framework, we construct three tests for neutrality and demonstrate their improved power compared to previous methods on simulated data.

stat.CO↗

MM-algorithms for traditional and convex NMF with Tweedie and Negative Binomial cost functions and empirical evaluation

Non-negative matrix factorisation (NMF) is a widely used tool for unsupervised learning and feature extraction, with applications ranging from genomics to text analysis and signal processing. Standard formulations of NMF are typically derived under Gaussian or Poisson noise assumptions, which may be inadequate for data exhibiting overdispersion or other complex mean-variance relationships. In this paper, we develop a unified framework for both traditional and convex NMF under a broad class of distributional assumptions, including Negative Binomial and Tweedie models, where the connection between the Tweedie and the $β$-divergence is also highlighted. Using a Majorize-Minimisation approach, we derive multiplicative update rules for all considered models, and novel updates for convex NMF with Poisson and Negative Binomial cost functions. We provide a unified implementation of all considered models, including the first implementations of several convex NMF models. Empirical evaluations on mutational and word count data demonstrate that the choice of noise model critically affects model fit and feature recovery, and that convex NMF can provide an efficient and robust alternative to traditional NMF in scenarios where the number of classes is large. The code for our proposed updates is available in the R package nmfgenr and can be found at https://github.com/MartaPelizzola/nmfgenr.

cs.LG↗