Elisavet Syriopoulou | Searcharxiv

arXiv2026

A non-parametric estimator for excess recurrent events

Measuring disease burden is an important part of both public health research and health economics. Some measures of disease burden, such as hospitalisations, are made up of recurrent events. Assessing what events are related to a particular disease is however non-trivial. We extend the notion of relative survival to recurrent events by developing a novel non-parametric estimator. The estimator combines data from some cohort with aggregated population level data to estimate the number of excess recurrent events. Using empirical process theory, we show that the estimator converges weakly to a mean zero Gaussian process under mild regularity conditions, and provide a consistent estimator for the covariance function. We also evaluate the finite sample properties of the estimator through simulations and provide a practical example using data from Swedish patients with rectal cancer.

stat.ME↗

arXiv2021

Estimating causal effects in the presence of competing events using regression standardisation with the Stata command standsurv

When interested in a time-to-event outcome, competing events that prevent the occurrence of the event of interest may be present. In the presence of competing events, various statistical estimands have been suggested for defining the causal effect of treatment on the event of interest. Depending on the estimand, the competing events are either accommodated or eliminated, resulting in causal effects with different interpretation. The former approach captures the total effect of treatment on the event of interest while the latter approach captures the direct effect of treatment on the event of interest that is not mediated by the competing event. Separable effects have also been defined for settings where the treatment effect can be partitioned into its effect on the event of interest and its effect on the competing event through different causal pathways. We outline various causal effects that may be of interest in the presence of competing events, including total, direct and separable effects, and describe how to obtain estimates using regression standardisation with the Stata command standsurv. Regression standardisation is applied by obtaining the average of individual estimates across all individuals in a study population after fitting a survival model. With standsurv several contrasts of interest can be calculated including differences, ratios and other user-defined functions. Confidence intervals can also be obtained using the delta method. Throughout we use an example analysing a publicly available dataset on prostate cancer to allow the reader to replicate the analysis and further explore the different effects of interest.

stat.ME↗