arXiv subjects

Emilie Devijver

Publications and source records attributed to Emilie Devijver.

44 records · Page 3Linked to original sources

arXiv2018

Prediction regions through Inverse Regression

Predict a new response from a covariate is a challenging task in regression, which raises new question since the era of high-dimensional data. In this paper, we are interested in the inverse regression method from a theoretical viewpoint. Theoretical results have already been derived for the well-known linear model, but recently, the curse of dimensionality has increased the interest of practitioners and theoreticians into generalization of those results for various estimators, calibrated for the high-dimension context. To deal with high-dimensional data, inverse regression is used in this paper. It is known to be a reliable and efficient approach when the number of features exceeds the number of observations. Indeed, under some conditions, dealing with the inverse regression problem associated to a forward regression problem drastically reduces the number of parameters to estimate and make the problem tractable. When both the responses and the covariates are multivariate, estimators constructed by the inverse regression are studied in this paper, the main result being explicit asymptotic prediction regions for the response. The performances of the proposed estimators and prediction regions are also analyzed through a simulation study and compared with usual estimators.

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arXiv2017

Nonlinear network-based quantitative trait prediction from transcriptomic data

Quantitatively predicting phenotype variables by the expression changes in a set of candidate genes is of great interest in molecular biology but it is also a challenging task for several reasons. First, the collected biological observations might be heterogeneous and correspond to different biological mechanisms. Secondly, the gene expression variables used to predict the phenotype are potentially highly correlated since genes interact though unknown regulatory networks. In this paper, we present a novel approach designed to predict quantitative trait from transcriptomic data, taking into account the heterogeneity in biological samples and the hidden gene regulatory networks underlying different biological mechanisms. The proposed model performs well on prediction but it is also fully parametric, which facilitates the downstream biological interpretation. The model provides clusters of individuals based on the relation between gene expression data and the phenotype, and also leads to infer a gene regulatory network specific for each cluster of individuals. We perform numerical simulations to demonstrate that our model is competitive with other prediction models, and we demonstrate the predictive performance and the interpretability of our model to predict alcohol sensitivity from transcriptomic data on real data from Drosophila Melanogaster Genetic Reference Panel (DGRP).

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arXiv2017

Joint rank and variable selection for parsimonious estimation in a high-dimensional finite mixture regression model

We study a dimensionality reduction technique for finite mixtures of high-dimensional multivariate response regression models. Both the dimension of the response and the number of predictors are allowed to exceed the sample size. We consider predictor selection and rank reduction to obtain lower-dimensional approximations. A class of estimators with a fast rate of convergence is introduced. We apply this result to a specific procedure, introduced in [11], where the relevant predictors are selected by the Group-Lasso.

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arXiv2016

Block-diagonal covariance selection for high-dimensional Gaussian graphical models

Gaussian graphical models are widely utilized to infer and visualize networks of dependencies between continuous variables. However, inferring the graph is difficult when the sample size is small compared to the number of variables. To reduce the number of parameters to estimate in the model, we propose a non-asymptotic model selection procedure supported by strong theoretical guarantees based on an oracle inequality and a minimax lower bound. The covariance matrix of the model is approximated by a block-diagonal matrix. The structure of this matrix is detected by thresholding the sample covariance matrix, where the threshold is selected using the slope heuristic. Based on the block-diagonal structure of the covariance matrix, the estimation problem is divided into several independent problems: subsequently, the network of dependencies between variables is inferred using the graphical lasso algorithm in each block. The performance of the procedure is illustrated on simulated data. An application to a real gene expression dataset with a limited sample size is also presented: the dimension reduction allows attention to be objectively focused on interactions among smaller subsets of genes, leading to a more parsimonious and interpretable modular network.

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arXiv2016

Model-based regression clustering for high-dimensional data. Application to functional data

Finite mixture regression models are useful for modeling the relationship between response and predictors, arising from different subpopulations. In this article, we study high-dimensional predic- tors and high-dimensional response, and propose two procedures to deal with this issue. We propose to use the Lasso estimator to take into account the sparsity, and a penalty on the rank, to take into account the matrix structure. Then, we extend these procedures to the functional case, where predictors and responses are functions. For this purpose, we use a wavelet-based approach. Finally, for each situation, we provide algorithms, and apply and evaluate our methods both on simulations and real datasets.

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arXiv2015

Clustering electricity consumers using high-dimensional regression mixture models

Massive informations about individual (household, small and medium enterprise) consumption are now provided with new metering technologies and the smart grid. Two major exploitations of these data are load profiling and forecasting at different scales on the grid. Customer segmentation based on load classification is a natural approach for these purposes. We propose here a new methodology based on mixture of high-dimensional regression models. The novelty of our approach is that we focus on uncovering classes or clusters corresponding to different regression models. As a consequence, these classes could then be exploited for profiling as well as forecasting in each class or for bottom-up forecasts in a unified view. We consider a real dataset of Irish individual consumers of 4,225 meters, each with 48 half-hourly meter reads per day over 1 year: from 1st January 2010 up to 31st December 2010, to demonstrate the feasibility of our approach.

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arXiv2014

An \ell_1-oracle inequality for the Lasso in finite mixture of multivariate Gaussian regression models

We consider a multivariate finite mixture of Gaussian regression models for high-dimensional data, where the number of covariates and the size of the response may be much larger than the sample size. We provide an $\ell_1$-oracle inequality satisfied by the Lasso estimator according to the Kullback-Leibler loss. This result is an extension of the $\ell_1$-oracle inequality established by Meynet in \cite{Meynet} in the multivariate case. We focus on the Lasso for its $\ell_1$-regularization properties rather than for the variable selection procedure, as it was done in Städler in \cite{Stadler}.

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arXiv2014

Finite mixture regression: A sparse variable selection by model selection for clustering

We consider a finite mixture of Gaussian regression model for high- dimensional data, where the number of covariates may be much larger than the sample size. We propose to estimate the unknown conditional mixture density by a maximum likelihood estimator, restricted on relevant variables selected by an 1-penalized maximum likelihood estimator. We get an oracle inequality satisfied by this estimator with a Jensen-Kullback-Leibler type loss. Our oracle inequality is deduced from a general model selection theorem for maximum likelihood estimators with a random model collection. We can derive the penalty shape of the criterion, which depends on the complexity of the random model collection.

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