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Emilija Perković

Publications and source records attributed to Emilija Perković.

13 recordsLinked to original sources

Lost in Aggregation: The Causal Interpretation of the IV Estimand

Instrumental variable estimation has emerged as a standard approach to mitigating confounding bias in the social sciences and epidemiology, where conducting randomized experiments can be too costly or infeasible. However, justifying the validity of the instrument is frequently challenging. We highlight a problem generally neglected in arguments for instrumental variable validity: the presence of an "aggregate treatment variable", where the treatment (e.g., education, GDP, caloric intake) is composed of finer-grained, unobserved components that each may have a different effect on the outcome. While the aggregation problem itself is general, our focus is on instrumental variable estimation in a linear setting, the regime underlying much of applied IV practice. We show that the causal effect of an aggregate treatment is generally ambiguous, as it depends on how an intervention on the aggregate is instantiated at the component level. We formalize this relation using the aggregate-constrained component intervention distribution (ACID). We then identify two key conditions under which standard instrumental variable estimators identify the aggregate effect. The contrived nature of these conditions implies major limitations on the interpretation of instrumental variable estimates based on aggregate treatments and highlights the need for a broader justificatory base for the exclusion restriction in such settings.

stat.ME

Towards Complete Causal Explanation with Expert Knowledge

We study the problem of restricting a Markov equivalence class of maximal ancestral graphs (MAGs) to only those MAGs that contain certain edge marks, which we refer to as expert or orientation knowledge. Such a restriction of the Markov equivalence class can be uniquely represented by a restricted essential ancestral graph. Our contributions are several-fold. First, we prove certain properties for the entire Markov equivalence class including a conjecture from Ali et al. (2009). Second, we present several new sound graphical orientation rules for adding orientation knowledge to an essential ancestral graph. We also show that some orientation rules of Zhang (2008b) are not needed for restricting the Markov equivalence class with orientation knowledge. Third, we provide an algorithm for including this orientation knowledge and show that in certain settings the output of our algorithm is a restricted essential ancestral graph. Finally, outside of the specified settings, we provide an algorithm for checking whether a graph is a restricted essential graph and discuss its runtime. This work can be seen as a generalization of Meek (1995) to settings which allow for latent confounding.

stat.ML

Data-Driven Adjustment for Multiple Treatments

Covariate adjustment is one method of causal effect identification in non-experimental settings. Prior research provides routes for finding appropriate adjustments sets, but much of this research assumes knowledge of the underlying causal graph. In this paper, we present two routes for finding adjustment sets that do not require knowledge of a graph -- and instead rely on dependencies and independencies in the data directly. We consider a setting where the adjustment set is unaffected by treatment or outcome. The first route shows how to extend prior research in this area using a concept known as c-equivalence. Our second route provides sufficient criteria for finding adjustment sets in the setting of multiple treatments.

stat.ME

Identifying causal effects in maximally oriented partially directed acyclic graphs

We develop a necessary and sufficient causal identification criterion for maximally oriented partially directed acyclic graphs (MPDAGs). MPDAGs as a class of graphs include directed acyclic graphs (DAGs), completed partially directed acyclic graphs (CPDAGs), and CPDAGs with added background knowledge. As such, they represent the type of graph that can be learned from observational data and background knowledge under the assumption of no latent variables. Our identification criterion can be seen as a generalization of the g-formula of Robins (1986). We further obtain a generalization of the truncated factorization formula (Pearl, 2009) and compare our criterion to the generalized adjustment criterion of Perković et al. (2017) which is sufficient, but not necessary for causal identification.

math.ST

Identifying Conditional Causal Effects in MPDAGs

We consider identifying a conditional causal effect when a graph is known up to a maximally oriented partially directed acyclic graph (MPDAG). An MPDAG represents an equivalence class of graphs that is restricted by background knowledge and where all variables in the causal model are observed. We provide three results that address identification in this setting: an identification formula when the conditioning set is unaffected by treatment, a generalization of the well-known do calculus to the MPDAG setting, and an algorithm that is complete for identifying these conditional effects.

cs.AI

Conditional Adjustment in a Markov Equivalence Class

We consider the problem of identifying a conditional causal effect through covariate adjustment. We focus on the setting where the causal graph is known up to one of two types of graphs: a maximally oriented partially directed acyclic graph (MPDAG) or a partial ancestral graph (PAG). Both MPDAGs and PAGs represent equivalence classes of possible underlying causal models. After defining adjustment sets in this setting, we provide a necessary and sufficient graphical criterion -- the conditional adjustment criterion -- for finding these sets under conditioning on variables unaffected by treatment. We further provide explicit sets from the graph that satisfy the conditional adjustment criterion, and therefore, can be used as adjustment sets for conditional causal effect identification.

stat.ME

Variable elimination, graph reduction and efficient g-formula

We study efficient estimation of an interventional mean associated with a point exposure treatment under a causal graphical model represented by a directed acyclic graph without hidden variables. Under such a model, it may happen that a subset of the variables are uninformative in that failure to measure them neither precludes identification of the interventional mean nor changes the semiparametric variance bound for regular estimators of it. We develop a set of graphical criteria that are sound and complete for eliminating all the uninformative variables so that the cost of measuring them can be saved without sacrificing estimation efficiency, which could be useful when designing a planned observational or randomized study. Further, we construct a reduced directed acyclic graph on the set of informative variables only. We show that the interventional mean is identified from the marginal law by the g-formula (Robins, 1986) associated with the reduced graph, and the semiparametric variance bounds for estimating the interventional mean under the original and the reduced graphical model agree. This g-formula is an irreducible, efficient identifying formula in the sense that the nonparametric estimator of the formula, under regularity conditions, is asymptotically efficient under the original causal graphical model, and no formula with such property exists that only depends on a strict subset of the variables.

math.ST

Efficient least squares for estimating total effects under linearity and causal sufficiency

Recursive linear structural equation models are widely used to postulate causal mechanisms underlying observational data. In these models, each variable equals a linear combination of a subset of the remaining variables plus an error term. When there is no unobserved confounding or selection bias, the error terms are assumed to be independent. We consider estimating a total causal effect in this setting. The causal structure is assumed to be known only up to a maximally oriented partially directed acyclic graph (MPDAG), a general class of graphs that can represent a Markov equivalence class of directed acyclic graphs (DAGs) with added background knowledge. We propose a simple estimator based on recursive least squares, which can consistently estimate any identified total causal effect, under point or joint intervention. We show that this estimator is the most efficient among all regular estimators that are based on the sample covariance, which includes covariate adjustment and the estimators employed by the joint-IDA algorithm. Notably, our result holds without assuming Gaussian errors.

math.ST

Minimal enumeration of all possible total effects in a Markov equivalence class

In observational studies, when a total causal effect of interest is not identified, the set of all possible effects can be reported instead. This typically occurs when the underlying causal DAG is only known up to a Markov equivalence class, or a refinement thereof due to background knowledge. As such, the class of possible causal DAGs is represented by a maximally oriented partially directed acyclic graph (MPDAG), which contains both directed and undirected edges. We characterize the minimal additional edge orientations required to identify a given total effect. A recursive algorithm is then developed to enumerate subclasses of DAGs, such that the total effect in each subclass is identified as a distinct functional of the observed distribution. This resolves an issue with existing methods, which often report possible total effects with duplicates, namely those that are numerically distinct due to sampling variability but are in fact causally identical.

math.ST

Graphical Criteria for Efficient Total Effect Estimation via Adjustment in Causal Linear Models

Covariate adjustment is a commonly used method for total causal effect estimation. In recent years, graphical criteria have been developed to identify all valid adjustment sets, that is, all covariate sets that can be used for this purpose. Different valid adjustment sets typically provide total effect estimates of varying accuracies. Restricting ourselves to causal linear models, we introduce a graphical criterion to compare the asymptotic variances provided by certain valid adjustment sets. We employ this result to develop two further graphical tools. First, we introduce a simple variance reducing pruning procedure for any given valid adjustment set. Second, we give a graphical characterization of a valid adjustment set that provides the optimal asymptotic variance among all valid adjustment sets. Our results depend only on the graphical structure and not on the specific error variances or edge coefficients of the underlying causal linear model. They can be applied to directed acyclic graphs (DAGs), completed partially directed acyclic graphs (CPDAGs) and maximally oriented partially directed acyclic graphs (maximal PDAGs). We present simulations and a real data example to support our results and show their practical applicability.

math.ST

Complete Graphical Characterization and Construction of Adjustment Sets in Markov Equivalence Classes of Ancestral Graphs

We present a graphical criterion for covariate adjustment that is sound and complete for four different classes of causal graphical models: directed acyclic graphs (DAGs), maximum ancestral graphs (MAGs), completed partially directed acyclic graphs (CPDAGs), and partial ancestral graphs (PAGs). Our criterion unifies covariate adjustment for a large set of graph classes. Moreover, we define an explicit set that satisfies our criterion, if there is any set that satisfies our criterion. We also give efficient algorithms for constructing all sets that fulfill our criterion, implemented in the R package dagitty. Finally, we discuss the relationship between our criterion and other criteria for adjustment, and we provide new soundness and completeness proofs for the adjustment criterion for DAGs.

math.ST

Interpreting and using CPDAGs with background knowledge

We develop terminology and methods for working with maximally oriented partially directed acyclic graphs (maximal PDAGs). Maximal PDAGs arise from imposing restrictions on a Markov equivalence class of directed acyclic graphs, or equivalently on its graphical representation as a completed partially directed acyclic graph (CPDAG), for example when adding background knowledge about certain edge orientations. Although maximal PDAGs often arise in practice, causal methods have been mostly developed for CPDAGs. In this paper, we extend such methodology to maximal PDAGs. In particular, we develop methodology to read off possible ancestral relationships, we introduce a graphical criterion for covariate adjustment to estimate total causal effects, and we adapt the IDA and joint-IDA frameworks to estimate multi-sets of possible causal effects. We also present a simulation study that illustrates the gain in identifiability of total causal effects as the background knowledge increases. All methods are implemented in the R package pcalg.

math.ST

A Complete Generalized Adjustment Criterion

Covariate adjustment is a widely used approach to estimate total causal effects from observational data. Several graphical criteria have been developed in recent years to identify valid covariates for adjustment from graphical causal models. These criteria can handle multiple causes, latent confounding, or partial knowledge of the causal structure; however, their diversity is confusing and some of them are only sufficient, but not necessary. In this paper, we present a criterion that is necessary and sufficient for four different classes of graphical causal models: directed acyclic graphs (DAGs), maximum ancestral graphs (MAGs), completed partially directed acyclic graphs (CPDAGs), and partial ancestral graphs (PAGs). Our criterion subsumes the existing ones and in this way unifies adjustment set construction for a large set of graph classes.

math.ST