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Emily Blanchard

Publications and source records attributed to Emily Blanchard.

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WavesFM: Hierarchical Representation Learning for Longitudinal Wearable Sensor Waveforms

Wearable sensors enable the continuous acquisition of high-resolution physiological waveforms, such as photoplethysmography and accelerometry, under free-living conditions. However, inferring health-related phenotypes from these signals presents significant challenges due to high sampling frequencies, multimodal dependencies, and extreme sequence lengths (e.g., weeks of recordings), compounded by a scarcity of ground-truth labels. To address these challenges, existing self-supervised learning (SSL) methodologies typically follow two paradigms: (1) learning rich morphological representations from short waveform segments while collapsing longitudinal dynamics through simple aggregation, or (2) modeling behavioral patterns from coarse, hand-crafted features (e.g. heart rate, step counts) spanning longer horizons but foregoing subtle, predictive signatures in raw waveforms. To bridge this gap, we propose WavesFM, a foundation model utilizing a two-stage SSL framework for longitudinal physiological data. Specifically, we decompose the learning problem into two stages: first, a segment-level encoder is pretrained to extract local embeddings from short waveforms; subsequently, a temporal encoder is trained to model the sequence of these embeddings across a multi-day horizon. This hierarchical approach overcomes the computational complexity of high-resolution, long-sequence data, allowing the overall model to capture both local signal semantics and the complex circadian and inter-day variations governing physiological dynamics. Pretrained on over 6.8M hours (N=324k individuals) of recordings for the first stage and 5.3M hours (N=10k) for the second stage, WavesFM demonstrates superior performance across 58 diverse tasks spanning demographics, lifestyle, health conditions, and medications.

cs.LG

Beyond BMI: Smartphone Body Composition Phenotyping for Cardiometabolic Risk Assessment

Body Mass Index (BMI) is a widely accessible but imprecise proxy of cardiometabolic health. While assessing true body composition is superior, gold-standard methods like Dual-Energy X-ray Absorptiometry (DXA) are not scalable. We address this gap by developing and validating "PhotoScan," a method to estimate body composition from smartphone imagery. We pretrained a deep learning model on UK Biobank participants (N=35,323) and fine-tuned on a newly recruited clinical cohort (PhotoBIA cohort, N=677) with diverse ethnicity, age, and body fat distribution, achieving high accuracy against DXA for total body fat percentage (BF%, MAE = 2.15%), Android-to-Gynoid fat ratio (A/G, MAE = 0.11), and visceral-to-subcutaneous fat area ratio (V/S, MAE = 0.09). Generalizability of the model was demonstrated on an independent metabolic health study cohort (MetabolicMosaic cohort, N=132 participants), achieving MAEs of 2.13% for BF%, 0.09 for A/G, and 0.09 for V/S. We then evaluated the clinical utility of these metrics in the MetabolicMosaic cohort by predicting insulin resistance (IR). Adding PhotoScan-derived body composition metrics to baseline demographics model (Age, Sex, BMI) significantly improved insulin resistance classification (Area Under the Receiver Operating Characteristic Curve "AUROC" 76.0% vs 69.2%, DeLong test p=0.002, Net Reclassification Index "NRI" 0.593). Crucially, this accessible smartphone method achieved performance nearly equivalent to adding clinical-grade DXA data to baseline demographics model (AUROC 77.3% vs 69.2%, DeLong test p=0.004, NRI 0.748). These findings demonstrate that smartphone-based phenotyping captures clinically meaningful risk signals missed by BMI and anthropometrics, offering a scalable alternative to DXA for cardiometabolic risk stratification.

q-bio.QM